Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 124 (29 Sep 2021)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Multidrug resistance protein 1

Gene

mdr1

Organism
Cryptococcus neoformans (Filobasidiella neoformans)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi534 – 541ATPPROSITE-ProRule annotation8
Nucleotide bindingi1197 – 1204ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.11, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multidrug resistance protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdr1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans (Filobasidiella neoformans)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5207 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:CKF44_00796
FungiDB:CNA07730
FungiDB:CNAG_00796
FungiDB:CNBA7570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei153 – 177HelicalSequence analysisAdd BLAST25
Transmembranei222 – 245HelicalSequence analysisAdd BLAST24
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei400 – 425HelicalSequence analysisAdd BLAST26
Transmembranei437 – 456HelicalSequence analysisAdd BLAST20
Transmembranei835 – 862HelicalSequence analysisAdd BLAST28
Transmembranei882 – 907HelicalSequence analysisAdd BLAST26
Transmembranei982 – 1001HelicalSequence analysisAdd BLAST20
Transmembranei1065 – 1090HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini157 – 464ABC transmembrane type-1InterPro annotationAdd BLAST308
Domaini499 – 744ABC transporterInterPro annotationAdd BLAST246
Domaini838 – 1125ABC transmembrane type-1InterPro annotationAdd BLAST288
Domaini1162 – 1402ABC transporterInterPro annotationAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 102DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili110 – 132Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 96Polar residuesSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 1 hit
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221, PTHR24221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43140-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASPGLTAA AAGPDHLQAR RDEKVIDSEK DALAHDAHAV NSGIPYPTAT
60 70 80 90 100
APNVGAPTVP ISVGRVSSAA EGKISRSSIA ASSDTLRNSP LEKPISNAFS
110 120 130 140 150
KSHPYKKSKF DFLKSRKKKE EEERKNKEKE KEASVLPPVS FFALFRFAAP
160 170 180 190 200
LEIIAMVLGL VLAVAAGSCQ PLMTLIFGRL TTSFTNYAVI ANQISQGGLT
210 220 230 240 250
PETSAALQAA KDDLKTQSGH NALYLMAIGI GMFLATWLYM FIWNVTGELN
260 270 280 290 300
SKRIRERYLA AVLRQEIAYF DDLGAGEVAT RIQTDCHLVQ EGTSEKVALV
310 320 330 340 350
FQYAGTFVCG FVLAFVRSPR LAGALVSILP VIMLCGGIMM TAMAKYGTAA
360 370 380 390 400
LDHIAKAGSL AEEVIGSIRT VQAFGKEKIL GDKFADHIEQ SKIVGRKGSI
410 420 430 440 450
FEGFGLSIMF FVIYAAYALA FFYGGILVSN GQADSGIVIN VFMSILIGSF
460 470 480 490 500
SMAMLAPELA AVTKARGAAA KLFATIDRVP AIDSASEEGF KPDGLRGEIS
510 520 530 540 550
FENVKFHYPS RPSIPILKGF TTTFEAGKTF ALVGASGSGK STVVSLIERF
560 570 580 590 600
YDPVSGVVKL DGRDIRSLNL NWLRQQIGLV SQEPTLFGTT VRGNVEHGLI
610 620 630 640 650
GSRYENASLE EKFELVKKAC VDANAHNFIM KLPQGYDTMV GERGMLLSGG
660 670 680 690 700
QKQRVAIARA IVSDPRILLL DEATSALDTQ SEGIVQDALD KASRGRTTIT
710 720 730 740 750
IAHRLSTIRD ADRIYVMGGG EVLEQGSHND LLANENGPYA QLVNNQKLAQ
760 770 780 790 800
EAAAEALQVD DDIEDPDDAV FIGGSSPMQE KDKQLHRAVT GRSLASIAMD
810 820 830 840 850
DIQAKRAEEV AGEDKIPSSF GLYARLLRMN SADKFIYIIA FIAAICAGMV
860 870 880 890 900
YPSLAILFGK ALSDFEIQDP AELRHALSRS ALWYFITALA AAFVIFFQSA
910 920 930 940 950
GFSRAGWDLN GVLRKKLFTA TLRHDIEWFD EERNSTGAVT SNLADQPQKV
960 970 980 990 1000
QGLFGPTLGT VVQSCATLIG GCIIGLCYGP LLALIGIACI PILVSGGYIR
1010 1020 1030 1040 1050
LKVVVLKDQR MKKLHAASAH LASEAAGAVK TVASLTREKD VRRIYSEALK
1060 1070 1080 1090 1100
APMKLNFRTS IKSQCLFAAS QGLTFCIIAL VFYIGALWII DAKYSTASFY
1110 1120 1130 1140 1150
TVLNSIVFAS IQAGNVFTFV PDASKANSSA ASIFRSIDNE PAINAESNEG
1160 1170 1180 1190 1200
KVLDHKHVVG HVRIEGVHFR YPTRPGVRVL RNLTIDVPAG TYVALVGPSG
1210 1220 1230 1240 1250
CGKSTTIQML ERFYDPLAGR VTLDGIDIKE LNLASYRSQI SLVSQEPTLY
1260 1270 1280 1290 1300
AGTIRFNILL GANKPIEEVT QDEIDAACKD ANIYDFIVSL PDGFDTEVGG
1310 1320 1330 1340 1350
KGSQLSGGQK QRIAIARALI RNPKVLLLDE ATSALDSQSE KVVQEALDKA
1360 1370 1380 1390 1400
AKGRTTIAIA HRLSSIQHSD RIYYFSEGRV AEHGTHQELL AKKGGYYELV

QMQNLSRQ
Length:1,408
Mass (Da):152,145
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE8A34A09A6F69F8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62929 mRNA Translation: AAC49889.1
U62930 Genomic DNA Translation: AAC49890.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43261

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62929 mRNA Translation: AAC49889.1
U62930 Genomic DNA Translation: AAC49890.1
PIRiT43261

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi3.A.1.201.11, the atp-binding cassette (abc) superfamily

Organism-specific databases

VEuPathDBiFungiDB:CKF44_00796
FungiDB:CNA07730
FungiDB:CNAG_00796
FungiDB:CNBA7570

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter
PANTHERiPTHR24221, PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO43140_CRYNE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43140
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 29, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again