Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Origin recognition complex subunit 5

Gene

orc5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 49ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB
  • DNA replication origin binding Source: UniProtKB

GO - Biological processi

  • mitotic DNA replication initiation Source: PomBase
  • mitotic sister chromatid cohesion Source: PomBase

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-68616 Assembly of the ORC complex at the origin of replication
R-SPO-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 5
Gene namesi
Name:orc5
Synonyms:orp5
ORF Names:SPBC646.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC646.14c
PomBaseiSPBC646.14c orc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270951 – 455Origin recognition complex subunit 5Add BLAST455

Proteomic databases

MaxQBiO43114
PaxDbiO43114
PRIDEiO43114

Interactioni

Subunit structurei

ORC is composed of six subunits. ORC interacts with cdc18, recruiting it to the ars1 origin of replication.2 Publications

Protein-protein interaction databases

BioGridi277622, 11 interactors
STRINGi4896.SPBC646.14c.1

Structurei

3D structure databases

ProteinModelPortaliO43114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC5 family.Curated

Phylogenomic databases

InParanoidiO43114
KOiK02607
OMAiGEQNIMD
OrthoDBiEOG092C1SOC
PhylomeDBiO43114

Family and domain databases

InterProiView protein in InterPro
IPR020796 ORC5
IPR027417 P-loop_NTPase
PANTHERiPTHR12705 PTHR12705, 1 hit
PfamiView protein in Pfam
PF14630 ORC5_C, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

O43114-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLYQLEDEL KKNVFCREDQ IKKLSCLLFN KDCRVPSIVL YGVASTAKTF
60 70 80 90 100
LLRTAFDLSK EENVWINLQD CFTVAHFWYR ILIKVGVDKD IALKKGINIS
110 120 130 140 150
GFIYLLEQAM SKRDYHTFLV LDQIDDFAEA STILFSQLAQ LPIVANIPNL
160 170 180 190 200
SIIFVLHSHP AQYLGTLSIA VIFFPQYTQA EILEICQKTP PNLDFLDRSG
210 220 230 240 250
DSVFEDEIEL SVWMQYCSFL WSVFGVQCLN DYRSFRSVLD RYWPKFIQPI
260 270 280 290 300
VEGDIHPADY AQLHKLAKNF LVSDATVTKR LHIINPTEIK NLLDSKSINL
310 320 330 340 350
SLVSKYLLVS AFLASYNPSR LDAQFFSFSK TSKRRGRKRK QIQDEGVLFS
360 370 380 390 400
KIPRTAGSKG RSAVKISQLT LGPKPFEVER LIAIYYAISS PVEKVLTADV
410 420 430 440 450
FVQIATLASL KMILSASKGV LRSLDSPRYI VNVSREYVLK IADSLSFPLD

SYLAG
Length:455
Mass (Da):51,762
Last modified:February 21, 2001 - v2
Checksum:iB7A6AC2CFF7D2FB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328F → S in AAC49897 (PubMed:9417919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92539 mRNA Translation: AAC49897.1
CU329671 Genomic DNA Translation: CAA22818.1
PIRiT40590
RefSeqiNP_595372.1, NM_001021280.2

Genome annotation databases

EnsemblFungiiSPBC646.14c.1; SPBC646.14c.1:pep; SPBC646.14c
GeneIDi2541107
KEGGispo:SPBC646.14c

Similar proteinsi

Entry informationi

Entry nameiORC5_SCHPO
AccessioniPrimary (citable) accession number: O43114
Secondary accession number(s): Q9UQW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again