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Protein

DNA repair and telomere maintenance protein nbs1

Gene

nbs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.2 Publications

GO - Molecular functioni

GO - Biological processi

  • DNA damage response, detection of DNA damage Source: PomBase
  • DNA duplex unwinding Source: GO_Central
  • DNA repair Source: UniProtKB
  • double-strand break repair Source: PomBase
  • double-strand break repair via homologous recombination Source: GO_Central
  • double-strand break repair via nonhomologous end joining Source: PomBase
  • intra-S DNA damage checkpoint Source: PomBase
  • meiotic DNA double-strand break clipping Source: PomBase
  • meiotic DNA double-strand break formation Source: PomBase
  • mitotic G2 DNA damage checkpoint Source: GO_Central
  • protein localization to chromosome, telomeric region Source: PomBase
  • protein localization to site of double-strand break Source: PomBase
  • signal transduction in response to DNA damage Source: GO_Central
  • signal transduction involved in DNA damage checkpoint Source: PomBase
  • telomere capping Source: GO_Central
  • telomere maintenance Source: UniProtKB
  • telomere maintenance via recombination Source: PomBase

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and telomere maintenance protein nbs1
Gene namesi
Name:nbs1
ORF Names:SPBC6B1.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC6B1.09c
PomBaseiSPBC6B1.09c nbs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000967511 – 613DNA repair and telomere maintenance protein nbs1Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei355Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43070
PaxDbiO43070
PRIDEiO43070

PTM databases

iPTMnetiO43070

Interactioni

Subunit structurei

Associates with rad32. Forms a multisubunit endonuclease complex, MRN, together with rad32 and rad50.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi280382, 12 interactors
DIPiDIP-52387N
IntActiO43070, 3 interactors
STRINGi4896.SPBC6B1.09c.1

Structurei

Secondary structure

1613
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Turni8 – 13Combined sources6
Beta strandi16 – 18Combined sources3
Beta strandi20 – 28Combined sources9
Beta strandi35 – 37Combined sources3
Beta strandi41 – 43Combined sources3
Beta strandi48 – 52Combined sources5
Helixi57 – 62Combined sources6
Beta strandi68 – 72Combined sources5
Beta strandi79 – 81Combined sources3
Beta strandi84 – 86Combined sources3
Beta strandi91 – 93Combined sources3
Beta strandi95 – 102Combined sources8
Beta strandi109 – 113Combined sources5
Beta strandi118 – 121Combined sources4
Helixi123 – 134Combined sources12
Turni135 – 137Combined sources3
Beta strandi140 – 143Combined sources4
Beta strandi150 – 152Combined sources3
Beta strandi157 – 159Combined sources3
Helixi163 – 170Combined sources8
Beta strandi174 – 176Combined sources3
Helixi178 – 184Combined sources7
Helixi190 – 193Combined sources4
Helixi195 – 197Combined sources3
Helixi198 – 209Combined sources12
Helixi219 – 222Combined sources4
Turni223 – 228Combined sources6
Beta strandi230 – 234Combined sources5
Helixi238 – 246Combined sources9
Beta strandi250 – 254Combined sources5
Helixi257 – 259Combined sources3
Beta strandi264 – 267Combined sources4
Beta strandi269 – 273Combined sources5
Helixi275 – 279Combined sources5
Beta strandi283 – 285Combined sources3
Beta strandi291 – 293Combined sources3
Helixi294 – 302Combined sources9
Beta strandi303 – 306Combined sources4
Turni307 – 312Combined sources6
Helixi314 – 319Combined sources6
Helixi478 – 486Combined sources9
Beta strandi491 – 496Combined sources6

3D structure databases

ProteinModelPortaliO43070
SMRiO43070
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43070

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86FHAPROSITE-ProRule annotationAdd BLAST64

Phylogenomic databases

InParanoidiO43070
OrthoDBiEOG092C3AQO

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR036420 BRCT_dom_sf
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

O43070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWIIEAEGDI LKGKSRILFP GTYIVGRNVS DDSSHIQVIS KSISKRHARF
60 70 80 90 100
TILTPSEKDY FTGGPCEFEV KDLDTKFGTK VNEKVVGQNG DSYKEKDLKI
110 120 130 140 150
QLGKCPFTIN AYWRSMCIQF DNPEMLSQWA SNLNLLGIPT GLRDSDATTH
160 170 180 190 200
FVMNRQAGSS ITVGTMYAFL KKTVIIDDSY LQYLSTVKES VIEDASLMPD
210 220 230 240 250
ALECFKNIIK NNDQFPSSPE DCINSLEGFS CAMLNTSSES HHLLELLGLR
260 270 280 290 300
ISTFMSLGDI DKELISKTDF VVLNNAVYDS EKISFPEGIF CLTIEQLWKI
310 320 330 340 350
IIERNSRELI SKEIERLKYA TASNSTPQKI IQPQRHIQKN IVDDLFSVKK
360 370 380 390 400
PLPCSPKSKR VKTLENLSIM DFVQPKQMFG KEPEGYLSNQ SNNGSAQNKK
410 420 430 440 450
SGDNSEKTKN SLKSSSKKSA NTGSGQGKTK VEYVSYNSVD KGNSSPFKPL
460 470 480 490 500
ELNVVGEKKA NAEVDSLPSE NVQESEDDKA FEENRRLRNL GSVEYIRIMS
510 520 530 540 550
SEKSNANSRH TSKYYSGRKN FKKFQKKASQ KAPLQAFLSL SEHKKTEVFD
560 570 580 590 600
QDDTDLEPVP RLMSKVESIP AGASSDKSGK SSISKKSSNS FKELSPKTNN
610
DEDDEFNDLK FHF
Length:613
Mass (Da):68,807
Last modified:November 7, 2003 - v3
Checksum:iB3384CCC85F96DD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099299 mRNA Translation: BAC80248.1
AY269280 mRNA Translation: AAP32157.1
CU329671 Genomic DNA Translation: CAD88196.1
RefSeqiNP_001018823.1, NM_001022003.2

Genome annotation databases

EnsemblFungiiSPBC6B1.09c.1; SPBC6B1.09c.1:pep; SPBC6B1.09c
GeneIDi3361306
KEGGispo:SPBC6B1.09c

Entry informationi

Entry nameiNBS1_SCHPO
AccessioniPrimary (citable) accession number: O43070
Secondary accession number(s): Q86ZQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 7, 2003
Last modified: February 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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