UniProtKB - O43060 (EIF3F_SCHPO)
Protein
Eukaryotic translation initiation factor 3 subunit F
Gene
eif3f
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation1 Publication
GO - Molecular functioni
- thiol-dependent ubiquitin-specific protease activity Source: PomBase
- translation initiation factor activity Source: UniProtKB-UniRule
- translation initiation factor binding Source: GO_Central
GO - Biological processi
- cytoplasmic translational initiation Source: PomBase
- formation of cytoplasmic translation initiation complex Source: PomBase
- protein modification by small protein conjugation or removal Source: PomBase
- translational initiation Source: GO_Central
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
Reactomei | R-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-SPO-72649 Translation initiation complex formation R-SPO-72689 Formation of a pool of free 40S subunits R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex R-SPO-72702 Ribosomal scanning and start codon recognition R-SPO-72706 GTP hydrolysis and joining of the 60S ribosomal subunit |
Protein family/group databases
MEROPSi | M67.975 |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 3 subunit F1 PublicationUniRule annotationShort name: eIF3f1 PublicationUniRule annotation |
Gene namesi | Name:eif3f1 Publication ORF Names:SPBC4C3.07 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC4C3.07 |
PomBasei | SPBC4C3.07 |
Subcellular locationi
Other locations
- Cytoplasm UniRule annotation2 Publications
Cytosol
- cytosol Source: PomBase
Other locations
- cytoplasm Source: PomBase
- eukaryotic 43S preinitiation complex Source: PomBase
- eukaryotic 48S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic translation initiation factor 3 complex Source: PomBase
- eukaryotic translation initiation factor 3 complex, eIF3e Source: PomBase
- eukaryotic translation initiation factor 3 complex, eIF3m Source: PomBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000347327 | 1 – 302 | Eukaryotic translation initiation factor 3 subunit FAdd BLAST | 302 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 162 | PhosphoserineUniRule annotation1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O43060 |
PaxDbi | O43060 |
PRIDEi | O43060 |
PTM databases
iPTMneti | O43060 |
Interactioni
Subunit structurei
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.
UniRule annotation1 PublicationGO - Molecular functioni
- translation initiation factor binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 277385, 6 interactors |
STRINGi | 4896.SPBC4C3.07.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 165 | MPNPROSITE-ProRule annotationAdd BLAST | 143 |
Sequence similaritiesi
Belongs to the eIF-3 subunit F family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000241154 |
InParanoidi | O43060 |
KOi | K03249 |
OMAi | AVDMEYH |
PhylomeDBi | O43060 |
Family and domain databases
CDDi | cd08064 MPN_eIF3f, 1 hit |
HAMAPi | MF_03005 eIF3f, 1 hit |
InterProi | View protein in InterPro IPR027531 eIF3f IPR000555 JAMM/MPN+_dom IPR037518 MPN IPR024969 Rpn11/EIF3F_C |
PANTHERi | PTHR10540:SF6 PTHR10540:SF6, 1 hit |
Pfami | View protein in Pfam PF01398 JAB, 1 hit PF13012 MitMem_reg, 1 hit |
SMARTi | View protein in SMART SM00232 JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249 MPN, 1 hit |
i Sequence
Sequence statusi: Complete.
O43060-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALGTKHVLH LTKPSSRSSP LNIVIEPAVL FSILDHSTRK SENNQRVIGT
60 70 80 90 100
LLGTRSEDGR EIEIKSCFAV PHNESSEQVE VEMEYHRAMY HLHLKANPRE
110 120 130 140 150
VVVGWYATSP DLDAFSALIQ NLYASPAEPG TAPLGTYPHP CVHLTVNTDV
160 170 180 190 200
SSPLAIKTYV SSPVGITERL ADSCAFVPTP FTIRDDEAVR SGLKAVAAPK
210 220 230 240 250
NDPSRLASLF TDLQQLRRST LELLSMIERV SDYVQNVIDG SSPANVAVGR
260 270 280 290 300
YLMKCFSLIP CVEGQDFEKI FSSHLQDVLV VVYLANTLRT QVDIASRLNL
LP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA16829.1 |
PIRi | T40490 |
RefSeqi | NP_596298.1, NM_001022219.2 |
Genome annotation databases
EnsemblFungii | SPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07 |
GeneIDi | 2540868 |
KEGGi | spo:SPBC4C3.07 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA16829.1 |
PIRi | T40490 |
RefSeqi | NP_596298.1, NM_001022219.2 |
3D structure databases
SMRi | O43060 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 277385, 6 interactors |
STRINGi | 4896.SPBC4C3.07.1 |
Protein family/group databases
MEROPSi | M67.975 |
PTM databases
iPTMneti | O43060 |
Proteomic databases
MaxQBi | O43060 |
PaxDbi | O43060 |
PRIDEi | O43060 |
Genome annotation databases
EnsemblFungii | SPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07 |
GeneIDi | 2540868 |
KEGGi | spo:SPBC4C3.07 |
Organism-specific databases
EuPathDBi | FungiDB:SPBC4C3.07 |
PomBasei | SPBC4C3.07 |
Phylogenomic databases
HOGENOMi | HOG000241154 |
InParanoidi | O43060 |
KOi | K03249 |
OMAi | AVDMEYH |
PhylomeDBi | O43060 |
Enzyme and pathway databases
Reactomei | R-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-SPO-72649 Translation initiation complex formation R-SPO-72689 Formation of a pool of free 40S subunits R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex R-SPO-72702 Ribosomal scanning and start codon recognition R-SPO-72706 GTP hydrolysis and joining of the 60S ribosomal subunit |
Miscellaneous databases
PROi | PR:O43060 |
Family and domain databases
CDDi | cd08064 MPN_eIF3f, 1 hit |
HAMAPi | MF_03005 eIF3f, 1 hit |
InterProi | View protein in InterPro IPR027531 eIF3f IPR000555 JAMM/MPN+_dom IPR037518 MPN IPR024969 Rpn11/EIF3F_C |
PANTHERi | PTHR10540:SF6 PTHR10540:SF6, 1 hit |
Pfami | View protein in Pfam PF01398 JAB, 1 hit PF13012 MitMem_reg, 1 hit |
SMARTi | View protein in SMART SM00232 JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249 MPN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EIF3F_SCHPO | |
Accessioni | O43060Primary (citable) accession number: O43060 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | June 1, 1998 | |
Last modified: | July 31, 2019 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - SIMILARITY comments
Index of protein domains and families - Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names