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Protein

Eukaryotic translation initiation factor 3 subunit F

Gene

eif3f

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translational initiation Source: PomBase
  • formation of cytoplasmic translation initiation complex Source: PomBase
  • protein modification by small protein conjugation or removal Source: PomBase

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SPO-72702 Ribosomal scanning and start codon recognition

Protein family/group databases

MEROPSiM67.975

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit F1 PublicationUniRule annotation
Short name:
eIF3f1 PublicationUniRule annotation
Gene namesi
Name:eif3f1 Publication
ORF Names:SPBC4C3.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.07
PomBaseiSPBC4C3.07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473271 – 302Eukaryotic translation initiation factor 3 subunit FAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineUniRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43060
PaxDbiO43060
PRIDEiO43060

PTM databases

iPTMnetiO43060

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.UniRule annotation1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277385, 2 interactors
STRINGi4896.SPBC4C3.07.1

Structurei

3D structure databases

ProteinModelPortaliO43060
SMRiO43060
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 165MPNPROSITE-ProRule annotationAdd BLAST143

Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241154
InParanoidiO43060
KOiK03249
OMAiAVDMEYH
OrthoDBiEOG092C3KDS
PhylomeDBiO43060

Family and domain databases

CDDicd08064 MPN_eIF3f, 1 hit
HAMAPiMF_03005 eIF3f, 1 hit
InterProiView protein in InterPro
IPR027531 eIF3f
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF6 PTHR10540:SF6, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

O43060-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGTKHVLH LTKPSSRSSP LNIVIEPAVL FSILDHSTRK SENNQRVIGT
60 70 80 90 100
LLGTRSEDGR EIEIKSCFAV PHNESSEQVE VEMEYHRAMY HLHLKANPRE
110 120 130 140 150
VVVGWYATSP DLDAFSALIQ NLYASPAEPG TAPLGTYPHP CVHLTVNTDV
160 170 180 190 200
SSPLAIKTYV SSPVGITERL ADSCAFVPTP FTIRDDEAVR SGLKAVAAPK
210 220 230 240 250
NDPSRLASLF TDLQQLRRST LELLSMIERV SDYVQNVIDG SSPANVAVGR
260 270 280 290 300
YLMKCFSLIP CVEGQDFEKI FSSHLQDVLV VVYLANTLRT QVDIASRLNL

LP
Length:302
Mass (Da):33,251
Last modified:June 1, 1998 - v1
Checksum:iA046E087CF083D84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA16829.1
PIRiT40490
RefSeqiNP_596298.1, NM_001022219.2

Genome annotation databases

EnsemblFungiiSPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07
GeneIDi2540868
KEGGispo:SPBC4C3.07

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA16829.1
PIRiT40490
RefSeqiNP_596298.1, NM_001022219.2

3D structure databases

ProteinModelPortaliO43060
SMRiO43060
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277385, 2 interactors
STRINGi4896.SPBC4C3.07.1

Protein family/group databases

MEROPSiM67.975

PTM databases

iPTMnetiO43060

Proteomic databases

MaxQBiO43060
PaxDbiO43060
PRIDEiO43060

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07
GeneIDi2540868
KEGGispo:SPBC4C3.07

Organism-specific databases

EuPathDBiFungiDB:SPBC4C3.07
PomBaseiSPBC4C3.07

Phylogenomic databases

HOGENOMiHOG000241154
InParanoidiO43060
KOiK03249
OMAiAVDMEYH
OrthoDBiEOG092C3KDS
PhylomeDBiO43060

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SPO-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

PROiPR:O43060

Family and domain databases

CDDicd08064 MPN_eIF3f, 1 hit
HAMAPiMF_03005 eIF3f, 1 hit
InterProiView protein in InterPro
IPR027531 eIF3f
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF6 PTHR10540:SF6, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3F_SCHPO
AccessioniPrimary (citable) accession number: O43060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 1998
Last modified: October 10, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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