eif3f

Functionⁱ

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation1 Publication

GO - Molecular functionⁱ

thiol-dependent ubiquitin-specific protease activity Source: PomBase
translation initiation factor activity Source: UniProtKB-UniRule
translation initiation factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic translational initiation
Source: PomBase
Inferred from mutant phenotypeⁱ
- 15904532
formation of cytoplasmic translation initiation complex
Source: PomBase
Inferred by curatorⁱ
- 19061185
protein modification by small protein conjugation or removal Source: PomBase

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor
Biological process	Protein biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-SPO-72689 Formation of a pool of free 40S subunits R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex R-SPO-72702 Ribosomal scanning and start codon recognition

Reactomeⁱ

R-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SPO-72702 Ribosomal scanning and start codon recognition

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M67.975

MEROPSⁱ

M67.975

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 3 subunit F1 PublicationUniRule annotation Short name: eIF3f1 PublicationUniRule annotation
Gene namesⁱ	Name:eif3f1 Publication ORF Names:SPBC4C3.07
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome II

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC4C3.07
PomBaseⁱ	SPBC4C3.07

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000347327	1 – 302	Eukaryotic translation initiation factor 3 subunit FAdd BLAST		302

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	162	PhosphoserineUniRule annotation1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43060
PaxDbⁱ	O43060
PRIDEⁱ	O43060

PTM databases

iPTMnetⁱ	O43060

iPTMnetⁱ

O43060

Interactionⁱ

Subunit structureⁱ

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.UniRule annotation1 Publication

GO - Molecular functionⁱ

translation initiation factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	277385, 2 interactors
STRINGⁱ	4896.SPBC4C3.07.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43060
SMRⁱ	O43060
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 165	MPNPROSITE-ProRule annotationAdd BLAST		143

Sequence similaritiesⁱ

Belongs to the eIF-3 subunit F family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000241154
InParanoidⁱ	O43060
KEGG Orthology (KO) More...KOⁱ	K03249
OMAⁱ	AVDMEYH
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3KDS
PhylomeDBⁱ	O43060

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08064 MPN_eIF3f, 1 hit
HAMAPⁱ	MF_03005 eIF3f, 1 hit
InterProⁱ	View protein in InterPro IPR027531 eIF3f IPR000555 JAMM/MPN+_dom IPR037518 MPN IPR024969 Rpn11/EIF3F_C
PANTHERⁱ	PTHR10540:SF6 PTHR10540:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01398 JAB, 1 hit PF13012 MitMem_reg, 1 hit
SMARTⁱ	View protein in SMART SM00232 JAB_MPN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50249 MPN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O43060-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALGTKHVLH LTKPSSRSSP LNIVIEPAVL FSILDHSTRK SENNQRVIGT 
        60         70         80         90        100
LLGTRSEDGR EIEIKSCFAV PHNESSEQVE VEMEYHRAMY HLHLKANPRE 
       110        120        130        140        150
VVVGWYATSP DLDAFSALIQ NLYASPAEPG TAPLGTYPHP CVHLTVNTDV 
       160        170        180        190        200
SSPLAIKTYV SSPVGITERL ADSCAFVPTP FTIRDDEAVR SGLKAVAAPK 
       210        220        230        240        250
NDPSRLASLF TDLQQLRRST LELLSMIERV SDYVQNVIDG SSPANVAVGR 
       260        270        280        290        300
YLMKCFSLIP CVEGQDFEKI FSSHLQDVLV VVYLANTLRT QVDIASRLNL 

LP

Length:302

Mass (Da):33,251

Last modified:June 1, 1998 - v1

Checksum:ⁱA046E087CF083D84

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CU329671 Genomic DNA Translation: CAA16829.1
PIRⁱ	T40490
NCBI Reference Sequences More...RefSeqⁱ	NP_596298.1, NM_001022219.2

Genome annotation databases

EnsemblFungiⁱ	SPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07
GeneIDⁱ	2540868
KEGGⁱ	spo:SPBC4C3.07

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43060	Eukaryotic translation initiation factor 3 subunit F		Lipomyces starkeyi NRRL Y-11557		292	UniRef50_O43060
Eukaryotic translation initiation factor 3 subunit F		Talaromyces marneffei PM1		332
Eukaryotic translation initiation factor 3 subunit F		Lobosporangium transversale		306
Eukaryotic translation initiation factor 3 subunit F		Mortierella elongata AG-77		305
Eukaryotic translation initiation factor 3 subunit F		SCHJY		302
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CU329671 Genomic DNA Translation: CAA16829.1
PIRⁱ	T40490
RefSeqⁱ	NP_596298.1, NM_001022219.2

3D structure databases

ProteinModelPortalⁱ	O43060
SMRⁱ	O43060
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	277385, 2 interactors
STRINGⁱ	4896.SPBC4C3.07.1

Protein family/group databases

MEROPSⁱ	M67.975

MEROPSⁱ

M67.975

PTM databases

iPTMnetⁱ	O43060

iPTMnetⁱ

O43060

Proteomic databases

MaxQBⁱ	O43060
PaxDbⁱ	O43060
PRIDEⁱ	O43060

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPBC4C3.07.1; SPBC4C3.07.1:pep; SPBC4C3.07
GeneIDⁱ	2540868
KEGGⁱ	spo:SPBC4C3.07

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC4C3.07
PomBaseⁱ	SPBC4C3.07

Phylogenomic databases

HOGENOMⁱ	HOG000241154
InParanoidⁱ	O43060
KOⁱ	K03249
OMAⁱ	AVDMEYH
OrthoDBⁱ	EOG092C3KDS
PhylomeDBⁱ	O43060

Enzyme and pathway databases

Reactomeⁱ	R-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-SPO-72689 Formation of a pool of free 40S subunits R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex R-SPO-72702 Ribosomal scanning and start codon recognition

Reactomeⁱ

R-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SPO-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O43060

PROⁱ

PR:O43060

Family and domain databases

CDDⁱ	cd08064 MPN_eIF3f, 1 hit
HAMAPⁱ	MF_03005 eIF3f, 1 hit
InterProⁱ	View protein in InterPro IPR027531 eIF3f IPR000555 JAMM/MPN+_dom IPR037518 MPN IPR024969 Rpn11/EIF3F_C
PANTHERⁱ	PTHR10540:SF6 PTHR10540:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF01398 JAB, 1 hit PF13012 MitMem_reg, 1 hit
SMARTⁱ	View protein in SMART SM00232 JAB_MPN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50249 MPN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EIF3F_SCHPO
Accessionⁱ	O43060Primary (citable) accession number: O43060
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	June 1, 1998
	Last modified:	October 10, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - O43060 (EIF3F_SCHPO)

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Eukaryotic translation initiation factor 3 subunit F

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ