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Entry version 124 (29 Sep 2021)
Sequence version 1 (01 Jun 1998)
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Protein

Nucleoporin nup120

Gene

nup120

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: PomBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-159227, Transport of the SLBP independent Mature mRNA
R-SPO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-SPO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-SPO-3371453, Regulation of HSF1-mediated heat shock response
R-SPO-4085377, SUMOylation of SUMOylation proteins
R-SPO-4551638, SUMOylation of chromatin organization proteins
R-SPO-4570464, SUMOylation of RNA binding proteins
R-SPO-5578749, Transcriptional regulation by small RNAs
R-SPO-9615933, Postmitotic nuclear pore complex (NPC) reformation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin nup120
Alternative name(s):
Nuclear pore protein nup120
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup120
ORF Names:SPBC3B9.16c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC3B9.16c, nup120

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC3B9.16c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002906671 – 1136Nucleoporin nup120Add BLAST1136

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43044

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43044

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O43044

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the npc107-120 complex which consists of nup85, nup107, nup120, nup131, nup132 and seh1.

Interacts with nup107.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277033, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-38661N

Protein interaction database and analysis system

More...
IntActi
O43044, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC3B9.16c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43044

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQWQ, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_277873_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43044

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEWERFA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43044

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021717, Nucleoporin_Nup160

The PANTHER Classification System

More...
PANTHERi
PTHR21286, PTHR21286, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43044-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNELKHAVVP IDLQSFCLEG TLALWVPALE NDSEDDSEAI ETADDNEKLF
60 70 80 90 100
KKECVAYDAG VYTSNKSKGS QTLRWSIFQN RTLTIFDVSL NSKKEPLSKF
110 120 130 140 150
NVKIHFPSNV MKDGVAFSFS EHSDTTIIYA ITHARVLYYI RLSKTWFQLP
160 170 180 190 200
DARLDDDWCL CYRPISFLNQ KPDLMAAIST SEICVSFFNG GLTKIILNPK
210 220 230 240 250
DASHYEQHID DSSYLFSLKK YLSLQAFKAD YRSPNTIISM IFLSTYNVLV
260 270 280 290 300
MLSLDYKLKV LDLSTNQCVE TIELSQTILP LQSFPYLTSD HTTNSFIALY
310 320 330 340 350
YPDNSHGSFS IYKLNANAHS FKLNVVIEKG IIPPSLPDDE FIPWMLSDFQ
360 370 380 390 400
LISSEGSQSK FLLIIAWKSN LNTVIQKCNL SLDQDESFSC VWSHSLDSFS
410 420 430 440 450
LIEKTFFDVP TNMSSGDISE IWLQHIFAHN TSIESIQVAL LSFQNSSSQV
460 470 480 490 500
SKNKLDKFGA LTISELKNAV LSSIVSTIQI EPNSDLTGYD YYEYKRLLYN
510 520 530 540 550
EWERFAKLVA YLDHFGDEIL SINFDPSNAV TYINYANKVA FIRDPYLIES
560 570 580 590 600
FDEEPLTKLI SSLETDDPSL IEGYQILDLG RSLHSCMSFS TLSEIRYSLR
610 620 630 640 650
ELVQDLPSYS LFDTLWVFYD KHIYPNVDPD YISTLIDTLV SLENPMRDID
660 670 680 690 700
SLIQRLRSFD IYNHSAQSPS LFLCASVARV LDSILKKFQV SIEGFIFLLS
710 720 730 740 750
LITSQQDYEL QSKFAGCDKL FLSLLEDWRL VSFLLENSAL LLEKFEEEDV
760 770 780 790 800
DSTNCNLNTM EALASVNTAL QFFSALNYSE CFSESQISPL HATVISSLSA
810 820 830 840 850
IFIRDDTEND LVTELVEKLF LFKQYNACMQ LIGWLNSDPI AVYLKALIYL
860 870 880 890 900
KSKEAVKAVR CFKTTSLVLY SHTSQFAVLR EFQEIAEKYH HQNLLSCYYL
910 920 930 940 950
HLSKKLFEES AYIDALEFSL LADASKETDD EDLSIAITHE TLKTACAAGK
960 970 980 990 1000
FDAAHVALMV LSTTPLKKSC LLDFVNQLTK QGKINQLLNY SMPTLRQDVD
1010 1020 1030 1040 1050
NLLERKAFQM INVESQPCWY NILFSWRYKH QNYRDAAAII YEKLSRYIST
1060 1070 1080 1090 1100
TELIGKKERT FIIEHYLIVL NTLELLPKED TWILVTDMSV DKEPDPNFLP
1110 1120 1130
QKLLTLDAIV AEYHLQLKDV AVQVTAEMSS AMNIDL
Length:1,136
Mass (Da):129,783
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D8E7A0839FA6FFE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17796.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40355

NCBI Reference Sequences

More...
RefSeqi
NP_596674.1, NM_001022596.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC3B9.16c.1; SPBC3B9.16c.1:pep; SPBC3B9.16c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC3B9.16c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17796.1
PIRiT40355
RefSeqiNP_596674.1, NM_001022596.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FHMX-ray4.34B1-961[»]
4FHNX-ray6.99B/D1-1136[»]
4GQ2X-ray2.40M1-949[»]
SMRiO43044
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi277033, 6 interactors
DIPiDIP-38661N
IntActiO43044, 3 interactors
STRINGi4896.SPBC3B9.16c.1

PTM databases

SwissPalmiO43044

Proteomic databases

MaxQBiO43044
PaxDbiO43044

Genome annotation databases

EnsemblFungiiSPBC3B9.16c.1; SPBC3B9.16c.1:pep; SPBC3B9.16c
GeneIDi2540505
KEGGispo:SPBC3B9.16c

Organism-specific databases

PomBaseiSPBC3B9.16c, nup120
VEuPathDBiFungiDB:SPBC3B9.16c

Phylogenomic databases

eggNOGiENOG502QQWQ, Eukaryota
HOGENOMiCLU_277873_0_0_1
InParanoidiO43044
OMAiNEWERFA
PhylomeDBiO43044

Enzyme and pathway databases

ReactomeiR-SPO-159227, Transport of the SLBP independent Mature mRNA
R-SPO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-SPO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-SPO-3371453, Regulation of HSF1-mediated heat shock response
R-SPO-4085377, SUMOylation of SUMOylation proteins
R-SPO-4551638, SUMOylation of chromatin organization proteins
R-SPO-4570464, SUMOylation of RNA binding proteins
R-SPO-5578749, Transcriptional regulation by small RNAs
R-SPO-9615933, Postmitotic nuclear pore complex (NPC) reformation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O43044

Family and domain databases

InterProiView protein in InterPro
IPR021717, Nucleoporin_Nup160
PANTHERiPTHR21286, PTHR21286, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU120_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43044
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 1, 1998
Last modified: September 29, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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