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Entry version 117 (08 May 2019)
Sequence version 1 (01 Jun 1998)
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Protein

Inositol-1,4,5-trisphosphate 5-phosphatase 1

Gene

syj1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Involved in distinct membrane trafficking and signal transduction pathways. Highly active against a range of soluble and lipid inositol phosphates. Active in dephosphorylating the 5-position of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 and to a lesser extent Ins(1,4,5,6)P4. The enzyme is also active against PI(4,5)P2 presented in sonicated vesicles and Triton mixed micelles, and somewhat less active against PI(3,5)P2 in unilamellar vesicles. Activity against PI(3,5)P2 drops sharply when this substrate is presented in mixed micelles. Also hydrolyzes PIP3 to produce PI(3,4)P2.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=57.8 µM for Ins(1,4,5)P3 (at pH 7.4 and 30 degrees Celsius)1 Publication
  2. KM=10.9 µM for Ins(2,4,5)P3 (at pH 7.4 and 30 degrees Celsius)1 Publication
  3. KM=75.9 µM for Ins(2,4)P2 (at pH 7.4 and 30 degrees Celsius)1 Publication
  4. KM=5860 µM for p-nitrophenyl phosphate (at pH 7 and 30 degrees Celsius)1 Publication
  5. KM=182 µM for 3-O-methylfluorescein phosphate (at pH 7 and 30 degrees Celsius)1 Publication
  6. KM=530 µM for magnesium ions1 Publication
  7. KM=12 µM for manganese ions1 Publication
  8. KM=6.39 µM for nickel ions1 Publication
  9. KM=14.5 µM for cobalt ions1 Publication

    pH dependencei

    Optimum pH is about 7.4.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid metabolism, Protein transport, Transport
    LigandMagnesium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-SPO-1660499 Synthesis of PIPs at the plasma membrane
    R-SPO-1855183 Synthesis of IP2, IP, and Ins in the cytosol
    R-SPO-1855204 Synthesis of IP3 and IP4 in the cytosol
    R-SPO-8856828 Clathrin-mediated endocytosis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    O43001

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Inositol-1,4,5-trisphosphate 5-phosphatase 1 (EC:3.1.3.36)
    Alternative name(s):
    Synaptojanin-like protein 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:syj1
    ORF Names:SPBC2G2.02
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    FungiDB:SPBC2G2.02

    Schizosaccharomyces pombe database

    More...
    PomBasei
    SPBC2G2.02 syj1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi597E → A or Q: Reduces the catalytic activity by 3 to 4 orders of magnitude. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097361 – 1076Inositol-1,4,5-trisphosphate 5-phosphatase 1Add BLAST1076

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O43001

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O43001

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O43001

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O43001

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    276801, 39 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    4896.SPBC2G2.02.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    11076
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O43001

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O43001

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 474SACPROSITE-ProRule annotationAdd BLAST331

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni534 – 880CatalyticAdd BLAST347

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1000 – 1048Pro-richAdd BLAST49

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the synaptojanin family.Curated
    In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000179717

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O43001

    KEGG Orthology (KO)

    More...
    KOi
    K20279

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QGGSKLM

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O43001

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.60.10.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036691 Endo/exonu/phosph_ase_sf
    IPR005135 Endo/exonuclease/phosphatase
    IPR000300 IPPc
    IPR002013 SAC_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03372 Exo_endo_phos, 1 hit
    PF02383 Syja_N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00128 IPPc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56219 SSF56219, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50275 SAC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    O43001-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MQCLLREKPR SLALVNKDHA LMFHSVPQNK NSLSVCVAEF TALSEKPLEG
    60 70 80 90 100
    FRKISSHRIY GTLGLIELEG SNFLCVISGA SEVARVRDKE RVFRIMEVCF
    110 120 130 140 150
    YSVNRSNWDH IRQENYSPDI PDGYDTDTQG YDSYKYAAEP FSSLRKLLTN
    160 170 180 190 200
    GSFYFSLDFD ITTRLQLRTS QTMTEPQYDS MHTQFMWNEF MLRQLIKFRS
    210 220 230 240 250
    HLNGDEKSAL DGCRFFTCAI RGFASTEQFK LGIQTIRLSL ISRLSSLRAG
    260 270 280 290 300
    TRFLSRGVDD DGNVANFVET ETILDSSKYC VSYCQVRGSI PIFWEQEGVQ
    310 320 330 340 350
    MFGQKIDITR SLEATRAAFE KHFTSLIEEY GPVHIINLLG TGSGERSLSE
    360 370 380 390 400
    RLRQHIQLSP EKDLIHLTEF DYHSQIRSFE DANKIRPMIY SDAETFGFYF
    410 420 430 440 450
    ENNEGQSIVV QDGVFRTNCL DCLDRTNVIQ NLVSRVFLEQ VMIYTRQNAG
    460 470 480 490 500
    YDFWQVHSTI WANNGDALAR IYTGTGALKS SFTRKGKLSI AGALNDLSKS
    510 520 530 540 550
    VGRMYINNFQ DKGRQETIDL LLGRLIDQHP VILYDPIHEY VNHELRKREN
    560 570 580 590 600
    EFSEHKNVKI FVASYNLNGC SATTKLENWL FPENTPLADI YVVGFQEIVQ
    610 620 630 640 650
    LTPQQVISAD PAKRREWESC VKRLLNGKCT SGPGYVQLRS GQLVGTALMI
    660 670 680 690 700
    FCKESCLPSI KNVEGTVKKT GLGGVSGNKG AVAIRFDYED TGLCFITSHL
    710 720 730 740 750
    AAGYTNYDER DHDYRTIASG LRFRRGRSIF NHDYVVWFGD FNYRISLTYE
    760 770 780 790 800
    EVVPCIAQGK LSYLFEYDQL NKQMLTGKVF PFFSELPITF PPTYKFDIGT
    810 820 830 840 850
    DIYDTSDKHR VPAWTDRILY RGELVPHSYQ SVPLYYSDHR PIYATYEANI
    860 870 880 890 900
    VKVDREKKKI LFEELYNQRK QEVRDASQTS YTLIDIAGSV AGKPNLIPHL
    910 920 930 940 950
    PANGVDKIKQ PSSERSKWWF DDGLPAKSIA APPGPEYRLN PSRPINPFEP
    960 970 980 990 1000
    TAEPDWISNT KQSFDKKSSL IDSIPALSPA PSSLARSSVS SQRSSTSIIP
    1010 1020 1030 1040 1050
    IKPNKPTKPD HLVAPRVKPL LPPRSGSSSS GVPAPNLTPV NVPPTPPPRK
    1060 1070
    SSASQRSGDL LASSPEESSI SWKPLV
    Length:1,076
    Mass (Da):121,822
    Last modified:June 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E26C9BF43AF20B8
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CU329671 Genomic DNA Translation: CAA17882.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T40141

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_596431.1, NM_001022350.2

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    SPBC2G2.02.1; SPBC2G2.02.1:pep; SPBC2G2.02

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2540270

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    spo:SPBC2G2.02

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CU329671 Genomic DNA Translation: CAA17882.1
    PIRiT40141
    RefSeqiNP_596431.1, NM_001022350.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1I9YX-ray2.00A534-880[»]
    1I9ZX-ray1.80A534-880[»]
    SMRiO43001
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi276801, 39 interactors
    STRINGi4896.SPBC2G2.02.1

    PTM databases

    iPTMnetiO43001

    Proteomic databases

    MaxQBiO43001
    PaxDbiO43001
    PRIDEiO43001

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblFungiiSPBC2G2.02.1; SPBC2G2.02.1:pep; SPBC2G2.02
    GeneIDi2540270
    KEGGispo:SPBC2G2.02

    Organism-specific databases

    EuPathDBiFungiDB:SPBC2G2.02
    PomBaseiSPBC2G2.02 syj1

    Phylogenomic databases

    HOGENOMiHOG000179717
    InParanoidiO43001
    KOiK20279
    OMAiQGGSKLM
    PhylomeDBiO43001

    Enzyme and pathway databases

    ReactomeiR-SPO-1660499 Synthesis of PIPs at the plasma membrane
    R-SPO-1855183 Synthesis of IP2, IP, and Ins in the cytosol
    R-SPO-1855204 Synthesis of IP3 and IP4 in the cytosol
    R-SPO-8856828 Clathrin-mediated endocytosis
    SABIO-RKiO43001

    Miscellaneous databases

    EvolutionaryTraceiO43001

    Protein Ontology

    More...
    PROi
    PR:O43001

    Family and domain databases

    Gene3Di3.60.10.10, 1 hit
    InterProiView protein in InterPro
    IPR036691 Endo/exonu/phosph_ase_sf
    IPR005135 Endo/exonuclease/phosphatase
    IPR000300 IPPc
    IPR002013 SAC_dom
    PfamiView protein in Pfam
    PF03372 Exo_endo_phos, 1 hit
    PF02383 Syja_N, 1 hit
    SMARTiView protein in SMART
    SM00128 IPPc, 1 hit
    SUPFAMiSSF56219 SSF56219, 1 hit
    PROSITEiView protein in PROSITE
    PS50275 SAC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYJ1_SCHPO
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43001
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 1998
    Last modified: May 8, 2019
    This is version 117 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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