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Entry version 137 (02 Dec 2020)
Sequence version 1 (01 Jun 1998)
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Protein

Ubiquitin-activating enzyme E1-like

Gene

uba2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56ATPBy similarity1
Binding sitei80ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi166ZincBy similarity1
Metal bindingi169ZincBy similarity1
Metal bindingi430ZincBy similarity1
Metal bindingi433ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi32 – 37ATPBy similarity6
Nucleotide bindingi35 – 59ATPBy similarityAdd BLAST25
Nucleotide bindingi64 – 67ATPBy similarity4
Nucleotide bindingi125 – 130ATPBy similarity6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00886

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-activating enzyme E1-like
Alternative name(s):
Pmt3-activating enzyme subunit 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uba2
ORF Names:SPBC16H5.03c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
FungiDB:SPBC16H5.03c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC16H5.03c, uba2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002486281 – 628Ubiquitin-activating enzyme E1-likeAdd BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei559Phosphoserine1 Publication1
Modified residuei563Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O42939

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O42939

PRoteomics IDEntifications database

More...
PRIDEi
O42939

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O42939

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of uba2 and aos1. The complex binds pmt3 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276511, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-35490N

Protein interaction database and analysis system

More...
IntActi
O42939, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC16H5.03c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O42939

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2013, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013325_7_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O42939

Identification of Orthologs from Complete Genome Data

More...
OMAi
YECTPKA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O42939

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.520, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000594, ThiF_NAD_FAD-bd
IPR028077, UAE_UbL_dom
IPR023318, Ub_act_enz_dom_a_sf
IPR030661, Uba2
IPR019572, UBA_E1_Cys
IPR035985, Ubiquitin-activating_enz
IPR033127, UBQ-activ_enz_E1_Cys_AS
IPR000011, UBQ/SUMO-activ_enz_E1-like

The PANTHER Classification System

More...
PANTHERi
PTHR10953:SF5, PTHR10953:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00899, ThiF, 1 hit
PF14732, UAE_UbL, 1 hit
PF10585, UBA_e1_thiolCys, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039133, SUMO_E1B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01849, UBIQUITINACT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69572, SSF69572, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00865, UBIQUITIN_ACTIVAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O42939-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTLMQLSND MKPLTFVEAL RNFKSAKVLL VGAGGIGCEL LKNLLMSGVK
60 70 80 90 100
EVHIIDLDTI DLSNLNRQFL FRKKHVKQPK AIVAAKTASS FNPNVKLEAY
110 120 130 140 150
HANIKEDRFN VAWFRQFDLV FNALDNLDAR RHVNKQCLLA SVPLIESGTT
160 170 180 190 200
GFLGQVQVII HGKTECYDCN PKEPPKTYPV CTIRSTPSQP IHCVVWAKSY
210 220 230 240 250
FFPQLFSNDQ ESDGIIDNVS ANEMERREIA ELARETTELN ELRSSIGQSD
260 270 280 290 300
NGFEKIFTKM FTKDIVRLRE VPDAWTYRSP PKELSYSELL ENAEKATSPW
310 320 330 340 350
LNEQNVWNVA ESFAVLRDSI RRLALRSKSS KDDLSFDKDD KDTLDFVAAA
360 370 380 390 400
ANLRAHVFGI QQLSEFDIKQ MAGNIIPAIA TTNAVIAGLC ITQAIKVLQG
410 420 430 440 450
DLNDLKNIYL AKRPTRVLHC EKTCKPNPYC PTCSFVLLQL GVNDKNMTLR
460 470 480 490 500
VLVDDILKSR LHYSEEVSVL NDKLIYDPDF DDNLDKTFDD LGINPAKNTI
510 520 530 540 550
LTVLGDSAVE KDDDGEEATR VPLLIEVTFI DSNSTEGLPY QILSNATSIP
560 570 580 590 600
LKQQPPSNSP EDSQVLTDEI NEVNDFSSSE RIVINLDEYD IIVDSKTSSH
610 620
NKQLKRRPSN DTLTQEAKSK KQAKIHTM
Length:628
Mass (Da):70,614
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAC9247BB8D2F634
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17901.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39623

NCBI Reference Sequences

More...
RefSeqi
NP_595945.1, NM_001021853.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC16H5.03c.1; SPBC16H5.03c.1:pep; SPBC16H5.03c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC16H5.03c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA17901.1
PIRiT39623
RefSeqiNP_595945.1, NM_001021853.2

3D structure databases

SMRiO42939
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276511, 3 interactors
DIPiDIP-35490N
IntActiO42939, 3 interactors
STRINGi4896.SPBC16H5.03c.1

PTM databases

iPTMnetiO42939

Proteomic databases

MaxQBiO42939
PaxDbiO42939
PRIDEiO42939

Genome annotation databases

EnsemblFungiiSPBC16H5.03c.1; SPBC16H5.03c.1:pep; SPBC16H5.03c
GeneIDi2539967
KEGGispo:SPBC16H5.03c

Organism-specific databases

EuPathDBiFungiDB:SPBC16H5.03c
PomBaseiSPBC16H5.03c, uba2

Phylogenomic databases

eggNOGiKOG2013, Eukaryota
HOGENOMiCLU_013325_7_3_1
InParanoidiO42939
OMAiYECTPKA
PhylomeDBiO42939

Enzyme and pathway databases

UniPathwayiUPA00886

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O42939

Family and domain databases

Gene3Di1.10.10.520, 1 hit
InterProiView protein in InterPro
IPR000594, ThiF_NAD_FAD-bd
IPR028077, UAE_UbL_dom
IPR023318, Ub_act_enz_dom_a_sf
IPR030661, Uba2
IPR019572, UBA_E1_Cys
IPR035985, Ubiquitin-activating_enz
IPR033127, UBQ-activ_enz_E1_Cys_AS
IPR000011, UBQ/SUMO-activ_enz_E1-like
PANTHERiPTHR10953:SF5, PTHR10953:SF5, 1 hit
PfamiView protein in Pfam
PF00899, ThiF, 1 hit
PF14732, UAE_UbL, 1 hit
PF10585, UBA_e1_thiolCys, 1 hit
PIRSFiPIRSF039133, SUMO_E1B, 1 hit
PRINTSiPR01849, UBIQUITINACT
SUPFAMiSSF69572, SSF69572, 1 hit
PROSITEiView protein in PROSITE
PS00865, UBIQUITIN_ACTIVAT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBA2_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42939
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: December 2, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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