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Entry version 147 (29 Sep 2021)
Sequence version 1 (01 Jun 1998)
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Protein

N-acetyltransferase eso1

Gene

eso1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. The relevance of acetyltransferase function remains unclear (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri533 – 567UBZ3-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri653 – 677CCHH-typeAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCell cycle, DNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-110320, Translesion Synthesis by POLH
R-SPO-5656169, Termination of translesion DNA synthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acetyltransferase eso1 (EC:2.3.1.-)
Alternative name(s):
ECO1 homolog
Sister chromatid cohesion protein eso1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eso1
ORF Names:SPBC16A3.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC16A3.11, eso1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC16A3.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001739941 – 872N-acetyltransferase eso1Add BLAST872

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O42917

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O42917

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O42917

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with pds5.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276221, 252 interactors

Protein interaction database and analysis system

More...
IntActi
O42917, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC16A3.11.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O42917

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 285UmuCPROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 591Polymerase type-YAdd BLAST591
Regioni569 – 602DisorderedSequence analysisAdd BLAST34
Regioni592 – 872AcetyltransferaseAdd BLAST281

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi572 – 586Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the acetyltransferase family. ECO subfamily.Curated
In the N-terminal section; belongs to the DNA polymerase type-Y family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri533 – 567UBZ3-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri653 – 677CCHH-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2095, Eukaryota
KOG3014, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_331802_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O42917

Identification of Orthologs from Complete Genome Data

More...
OMAi
SACNKPN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O42917

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.100, 1 hit
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028005, AcTrfase_ESCO_Znf_dom
IPR043502, DNA/RNA_pol_sf
IPR036775, DNA_pol_Y-fam_lit_finger_sf
IPR017961, DNA_pol_Y-fam_little_finger
IPR028009, ESCO_Acetyltransf_dom
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR041298, UBZ3
IPR001126, UmuC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13880, Acetyltransf_13, 1 hit
PF00817, IMS, 1 hit
PF11799, IMS_C, 1 hit
PF13878, zf-C2H2_3, 1 hit
PF18439, zf_UBZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100879, SSF100879, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50173, UMUC, 1 hit
PS51907, ZF_UBZ3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O42917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGKSKFSW KDLQYCDKAG TQNSPLRVVA HIDQDAFYAQ VESVRLGLDH
60 70 80 90 100
SVPLAVQQWQ GLIAVNYAAR AANISRHETV TEAKKKCPEL CTAHVKTWKA
110 120 130 140 150
GESEAKYHEN PNPNYYKTCL DPYRHESVKI LNIIKKHAPV VKKASIDECF
160 170 180 190 200
IELTSDVKRI VLEEYPYLKI PSEDSNVALP QAPVLLWPAE FGMVIEEEVV
210 220 230 240 250
DRTKEDYERD WDDVFLFYAA KIVKEIRDDI YLQLKYTCSA GVSFNPMLSK
260 270 280 290 300
LVSSRNKPNK QTILTKNAIQ DYLVSLKITD IRMLGGKFGE EIINLLGTDS
310 320 330 340 350
IKDVWNMSMD FLIDKLGQTN GPLVWNLCHG IDNTEITTQV QIKSMLSAKN
360 370 380 390 400
FSQQKVKSEE DAINWFQVFA SDLRSRFLEL EGMRRPKTIC LTVVSRFLRK
410 420 430 440 450
SRSSQIPMNV DISTQFIVEA TSKLLRQLQQ EFDVYPISNL SISFQNIIEV
460 470 480 490 500
DRNSRGIEGF LKKSNDEIYM STSVSPSIEG RAKLLNENMR ENNSFELSSE
510 520 530 540 550
KDIKSPKRLK RGKGKGIFDM LQQTAVSKPT ENSADETYTC EECEQKITLS
560 570 580 590 600
ERNEHEDYHI ALSISRKERY NNLVPPSHDK PKQVKPKTYG RKTGSKHYAP
610 620 630 640 650
LSDETNNKRA FLDAFLGNGG NLTPNWKKQT PKAISNSSDN MTQLHLDLAN
660 670 680 690 700
STVTCSECSM EYNSTSEEDI LLHSRFHSRV LGGVTVSFQC SPIYRVNYGL
710 720 730 740 750
SSDCIYSINS ESSLIDQRKA EEALSFVNNE LSSEPIETIG VDKYTTFLFI
760 770 780 790 800
SDKKCVGLLL AERISSAYIV DELELNNNNS TSSAVYIKNE NLRKGFVLGI
810 820 830 840 850
SRIWVSASRR KQGIASLLLD NALKKFIYGY VISPAEVAFS QPSESGKQFI
860 870
ISWHRSRNNG SSKSLRYAVY ES
Length:872
Mass (Da):98,909
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36ECCD2BC0AEFE94
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB039861 mRNA Translation: BAA95122.1
CU329671 Genomic DNA Translation: CAA16862.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39541

NCBI Reference Sequences

More...
RefSeqi
NP_596778.1, NM_001023799.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC16A3.11.1; SPBC16A3.11.1:pep; SPBC16A3.11

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC16A3.11

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039861 mRNA Translation: BAA95122.1
CU329671 Genomic DNA Translation: CAA16862.1
PIRiT39541
RefSeqiNP_596778.1, NM_001023799.2

3D structure databases

SMRiO42917
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276221, 252 interactors
IntActiO42917, 2 interactors
STRINGi4896.SPBC16A3.11.1

PTM databases

iPTMnetiO42917

Proteomic databases

MaxQBiO42917
PaxDbiO42917

Genome annotation databases

EnsemblFungiiSPBC16A3.11.1; SPBC16A3.11.1:pep; SPBC16A3.11
GeneIDi2539666
KEGGispo:SPBC16A3.11

Organism-specific databases

PomBaseiSPBC16A3.11, eso1
VEuPathDBiFungiDB:SPBC16A3.11

Phylogenomic databases

eggNOGiKOG2095, Eukaryota
KOG3014, Eukaryota
HOGENOMiCLU_331802_0_0_1
InParanoidiO42917
OMAiSACNKPN
PhylomeDBiO42917

Enzyme and pathway databases

ReactomeiR-SPO-110320, Translesion Synthesis by POLH
R-SPO-5656169, Termination of translesion DNA synthesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O42917

Family and domain databases

Gene3Di3.30.1490.100, 1 hit
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR028005, AcTrfase_ESCO_Znf_dom
IPR043502, DNA/RNA_pol_sf
IPR036775, DNA_pol_Y-fam_lit_finger_sf
IPR017961, DNA_pol_Y-fam_little_finger
IPR028009, ESCO_Acetyltransf_dom
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR041298, UBZ3
IPR001126, UmuC
PfamiView protein in Pfam
PF13880, Acetyltransf_13, 1 hit
PF00817, IMS, 1 hit
PF11799, IMS_C, 1 hit
PF13878, zf-C2H2_3, 1 hit
PF18439, zf_UBZ, 1 hit
SUPFAMiSSF100879, SSF100879, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50173, UMUC, 1 hit
PS51907, ZF_UBZ3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESO1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42917
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: September 29, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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