Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 119 (07 Oct 2020)
Sequence version 2 (07 Jun 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Neutral trehalase

Gene

treB

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possibly involved in mobilization of cytosolic trehalose.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei286SubstrateBy similarity1
Binding sitei330SubstrateBy similarity1
Binding sitei339SubstrateBy similarity1
Binding sitei458Substrate; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei460Proton donor/acceptorBy similarity1
Active sitei665Proton donor/acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.28, 3627

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH37, Glycoside Hydrolase Family 37

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutral trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:treB
ORF Names:G15D1.050, NCU04221
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Linkage Group V, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:NCU04221

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001737961 – 744Neutral trehalaseAdd BLAST744

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O42783

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 294Substrate bindingBy similarity2
Regioni339 – 341Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006451_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O42783

KEGG Orthology (KO)

More...
KOi
K01194

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFGWAPQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR001661, Glyco_hydro_37
IPR018232, Glyco_hydro_37_CS
IPR011120, Trehalase_Ca-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23403, PTHR23403, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01204, Trehalase, 1 hit
PF07492, Trehalase_Ca-bi, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00744, GLHYDRLASE37

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208, SSF48208, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00927, TREHALASE_1, 1 hit
PS00928, TREHALASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O42783-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSQPSSGKG RGRNLSIDEY NVYDDAKTYY TTEDRHHNHR AGARTRTYSQ
60 70 80 90 100
NSLFKQFERL GLQKEPYRRG SHDESTIPQS RRFLIQVEPT LQSLQSQEDT
110 120 130 140 150
DGNMQITIED NGPKVLSLRT AASNGYNRFD IRGTYMLSNL LQELYLAKEY
160 170 180 190 200
GRKQIILDEA RLNENPVNRL SRLIKDHFWE GLTRRIDASS IEIAARDPKD
210 220 230 240 250
WTDDPRPRIY IPRGAPEQHE YYTKVALDRP ELRLDVQYLP EKITPEIVRD
260 270 280 290 300
MNAKPGLLAV DMEEVVDPKT GEKTLRGRPF VVPGGRFNEL YGWDSYMESL
310 320 330 340 350
GLLVNDRVDL AKSMVQNFCF CIKHYGKILN ATRSYYLCRS QPPFLTDMTL
360 370 380 390 400
RVYDKIKHEP GALEFLRQSL LAAIKEYYSV WTAEPRLDPV TGLSRYRPEG
410 420 430 440 450
LGVPPETEAG HFIHILEPYA KKHNMSFDEF VYAYNHGEIK EPTLDDYFMH
460 470 480 490 500
DRAVRESGHD TTYRFEGICA DLATIDLNSL LFKYETDIAR TIRNVFHDKF
510 520 530 540 550
EVPDDWLATN NPAASKLETS AMWDRRAKRR KLAIDKYLWN EEAGMYFDYN
560 570 580 590 600
TATRKQCNYE SATTFWALWA GVSNPKQAAA MVTKALPKLE AFGGLLSGTK
610 620 630 640 650
ESRGEIGLER PNRQWDYPYG WAPQQILAWT GLYRYGFNEE AERLAYKWLF
660 670 680 690 700
MITKAFVDFN GVVVEKYDVT RPIDPHRVDA EYGNQGLDFK GVAKEGFGWV
710 720 730 740
NASYVYGLQI VNAHMRRALG TLTPYETFMK AVEENRNKAL SELV
Length:744
Mass (Da):85,969
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B916903C0656092
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC01744 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF044218 mRNA Translation: AAC01744.1 Frameshift.
AL807369 Genomic DNA Translation: CAD36994.1
CM002240 Genomic DNA Translation: EAA31609.1

NCBI Reference Sequences

More...
RefSeqi
XP_960845.1, XM_955752.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA31609; EAA31609; NCU04221

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3876992

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU04221

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044218 mRNA Translation: AAC01744.1 Frameshift.
AL807369 Genomic DNA Translation: CAD36994.1
CM002240 Genomic DNA Translation: EAA31609.1
RefSeqiXP_960845.1, XM_955752.3

3D structure databases

SMRiO42783
ModBaseiSearch...

Protein family/group databases

CAZyiGH37, Glycoside Hydrolase Family 37

Genome annotation databases

EnsemblFungiiEAA31609; EAA31609; NCU04221
GeneIDi3876992
KEGGincr:NCU04221

Organism-specific databases

EuPathDBiFungiDB:NCU04221

Phylogenomic databases

HOGENOMiCLU_006451_1_1_1
InParanoidiO42783
KOiK01194
OMAiPFGWAPQ

Enzyme and pathway databases

BRENDAi3.2.1.28, 3627

Family and domain databases

InterProiView protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR001661, Glyco_hydro_37
IPR018232, Glyco_hydro_37_CS
IPR011120, Trehalase_Ca-bd
PANTHERiPTHR23403, PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204, Trehalase, 1 hit
PF07492, Trehalase_Ca-bi, 1 hit
PRINTSiPR00744, GLHYDRLASE37
SUPFAMiSSF48208, SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00927, TREHALASE_1, 1 hit
PS00928, TREHALASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTREB_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42783
Secondary accession number(s): Q1K6U9, Q8NIK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 7, 2005
Last modified: October 7, 2020
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again