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Entry version 112 (10 Feb 2021)
Sequence version 2 (12 Jun 2007)
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Protein

Neutral trehalase

Gene

NTH1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in pathogenicity, specifically in proliferation of invasive hyphae in rice blast disease.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei279SubstrateBy similarity1
Binding sitei323SubstrateBy similarity1
Binding sitei332SubstrateBy similarity1
Binding sitei451Substrate; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei453Proton donor/acceptorBy similarity1
Active sitei657Proton donor/acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processStress response

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH37, Glycoside Hydrolase Family 37

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutral trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTH1
Synonyms:PTH9
ORF Names:MGG_09471
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri242507 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesPyriculariaceaePyricularia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009058 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:MGG_09471

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:123
PHI:7227
PHI:775
PHI:794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001737951 – 736Neutral trehalaseAdd BLAST736

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During sporulation, plant infection and in response to hyperosmotic stress.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
318829.MGG_09471T0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O42622

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni286 – 287Substrate bindingBy similarity2
Regioni332 – 334Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0602, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006451_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O42622

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFGWAPQ

Database of Orthologous Groups

More...
OrthoDBi
417479at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR001661, Glyco_hydro_37
IPR018232, Glyco_hydro_37_CS
IPR011120, Trehalase_Ca-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23403, PTHR23403, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01204, Trehalase, 1 hit
PF07492, Trehalase_Ca-bi, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00744, GLHYDRLASE37

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208, SSF48208, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00927, TREHALASE_1, 1 hit
PS00928, TREHALASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O42622-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEAPQARRV GSVDDHSVYD DAKTYYTSEE RHNNSRSGPR QRTYSQNSLL
60 70 80 90 100
GQMERLGLKE PFRRGSHDES NHNRRFLIQV DPTLESLKSQ EDTDGNMQIT
110 120 130 140 150
IEDNGPKVLT LRTAGSNGHN RFDIRGTYML SNLLQELTLA QEYGRKQVIL
160 170 180 190 200
DEARLNENPV NRLSRLIRDH FWDALTRRID ASSIEVAAKD PKDWTDDPRP
210 220 230 240 250
RIYVPKGAPE QLEYYKKLAA DKPDIRLDVV ELPETITPEY VVGINKAPGL
260 270 280 290 300
LAVDMEETVD PKTGERVMSG RPFVVPGGRF NELYGWDSYM ESLGLLVNDK
310 320 330 340 350
VYLAKSMVLN FCFCIKHYGK ILNATRSYYL CRSQPPFLTD MALRVYDKIR
360 370 380 390 400
HEPDATEFLR TAILAAIKEY HSVWVAEPRL DPVTGLSRYR PEGTGVPPET
410 420 430 440 450
EADHFLHILE PYYKKHNMTF KEFVEAYNFG RIREPELDKY FLHDRAVRES
460 470 480 490 500
GHDTSYRLEG VCADLATVDL NTLLFKYETD IARTIRNVFG DKLVIPAEYC
510 520 530 540 550
VGSLQPGQVE TSAIWDRRSK RRKLAIDKYL WNEEAGMYFD YDTAKRQQCN
560 570 580 590 600
YESCTTFWAL WAGVASPKQA AIMVTRALPK FEAYGGLLSG TEESRGQIGL
610 620 630 640 650
DRPNRQWDYP YGWAPQQMLA WTGLYRYSFT EEAERLAYKW LFMITKAFSD
660 670 680 690 700
FNGVVVEKYD VTRPVDPHRV DAEYGNQGLG FKGVAKEGFG WVNASYIYGL
710 720 730
QIINAHMRRA LGTLTPYDTF IKALEDNRNR ALSEMV
Length:736
Mass (Da):84,603
Last modified:June 12, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F8CDE4C8CAB0983
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti394T → A in strain: Guyane 11. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF027981 Genomic DNA Translation: AAB88889.1
AY148092 Genomic DNA Translation: AAN46743.1
CM001233 Genomic DNA Translation: EHA52473.1

NCBI Reference Sequences

More...
RefSeqi
XP_003712280.1, XM_003712232.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
MGG_09471T0; MGG_09471T0; MGG_09471

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2680514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mgr:MGG_09471

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027981 Genomic DNA Translation: AAB88889.1
AY148092 Genomic DNA Translation: AAN46743.1
CM001233 Genomic DNA Translation: EHA52473.1
RefSeqiXP_003712280.1, XM_003712232.1

3D structure databases

SMRiO42622
ModBaseiSearch...

Protein-protein interaction databases

STRINGi318829.MGG_09471T0

Protein family/group databases

CAZyiGH37, Glycoside Hydrolase Family 37

Genome annotation databases

EnsemblFungiiMGG_09471T0; MGG_09471T0; MGG_09471
GeneIDi2680514
KEGGimgr:MGG_09471

Organism-specific databases

VEuPathDBiFungiDB:MGG_09471

Phylogenomic databases

eggNOGiKOG0602, Eukaryota
HOGENOMiCLU_006451_1_1_1
InParanoidiO42622
OMAiPFGWAPQ
OrthoDBi417479at2759

Miscellaneous databases

PHI-baseiPHI:123
PHI:7227
PHI:775
PHI:794

Family and domain databases

InterProiView protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR001661, Glyco_hydro_37
IPR018232, Glyco_hydro_37_CS
IPR011120, Trehalase_Ca-bd
PANTHERiPTHR23403, PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204, Trehalase, 1 hit
PF07492, Trehalase_Ca-bi, 1 hit
PRINTSiPR00744, GLHYDRLASE37
SUPFAMiSSF48208, SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00927, TREHALASE_1, 1 hit
PS00928, TREHALASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTREB_MAGO7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42622
Secondary accession number(s): G4N1V8, Q875L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 12, 2007
Last modified: February 10, 2021
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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