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Protein
Submitted name:

Integrin alphaV subunit

Gene

itgav

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alphaV subunitImported
Gene namesi
Name:itgavImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865825 itgav

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei979 – 1001HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_500142568420 – 1033UniRule annotationAdd BLAST1014

Structurei

3D structure databases

ProteinModelPortaliO42598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 86FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati96 – 154FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati161 – 213FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati225 – 279FG-GAPPROSITE-ProRule annotationAdd BLAST55
Repeati280 – 345FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati346 – 404FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati408 – 471FG-GAPPROSITE-ProRule annotationAdd BLAST64
Domaini456 – 899Integrin_alpha2InterPro annotationAdd BLAST444

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG006186
KOiK06487

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

O42598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALVLLLHF LCIRQLCYCF NLDVDNPFVK SGAEGSYFGF AVDFLSTGSS
60 70 80 90 100
GSYLLVGAPK ANTSQPGIIE GGDVIKCDWK KSDCQSVVFD PNGNRNYAVN
110 120 130 140 150
ESIEFKSHQW FGASVRAKHN KIMACAPLYH WRTEVKQERE PVGTCYLNDG
160 170 180 190 200
TTVVEYAPCR SSAKTDAQEH GFCQGGFSIE FTEADRVLLG GPGSFYWQGQ
210 220 230 240 250
LISDQVDEIV KKYTPGKYSI TYENQLATRP ASPSHDDSYL GYSVTVGDFN
260 270 280 290 300
GDNIEDFVSG VPRAAKTLGM VSIYDGKSMV SLYNFTGEQM AAYFGYSVAT
310 320 330 340 350
SDINGDGLVD LFIGTPLFMD RGSDGKLQEL GQVSVYLQHS TNGPQPLLKL
360 370 380 390 400
TGFEVFARFG SCIGPLGDVD GDGFNDLAIA APYGGVNKKG LVYIYNGRPT
410 420 430 440 450
GLSVVPSQIL EGQWASQHMP SSFGYSLKGA TDVDENGYPD LLVGAFGADK
460 470 480 490 500
AILYRARPVI TVTSLLEVNP TILNPESKTC ILPSGTKVSC FHVKFCLKAV
510 520 530 540 550
GKGRVPQDLP FRVDLLLDKH KQKGAIRRAL FLHTRLSSHS KNMTIQNGGS
560 570 580 590 600
MRCEELQAFL RDDSEFRDKL TPITIFMEFQ MDYKSTADSS GLLPILNQFT
610 620 630 640 650
PANITKQAHI LLDCGEDNIC KPSLKLSVES EQKKIFIGDD SPLTLIVNAQ
660 670 680 690 700
NQGEGAYEAE LVVQMPPEAD FIGVIRNNET FSRLSCAFKT ENQTNLVVCD
710 720 730 740 750
LGNPMKAGTQ IKAALLFSVH QLTEMDNSVK FDLQIRSSNQ YENSSTVESI
760 770 780 790 800
EIALAVLAAV EVRGVSTPNE VFLPIANWEP KVNPVTEEDI GPLVQHIFEL
810 820 830 840 850
RNNGPSGFSK AILNLQWPYR YNNDTLLYIV KYETDGPMDC TSDVEINPLN
860 870 880 890 900
VKISTSQSDE KNESRVPDNR QRNRRDLTAM DGPLQTLGCG QAECLKIECH
910 920 930 940 950
VGRLDKGKSA ILYVRSRLWT QTFLQNGNQN HSYSLKSSAS FSVLEFPYKN
960 970 980 990 1000
IHIPDIQNST VVTTNILWVN QAASLPVPIW VIILAVLSGL LLLSLMVFIM
1010 1020 1030
YKLGFFKRVR PPQEETEREQ LQPQENGEGI TDT
Length:1,033
Mass (Da):114,025
Last modified:January 1, 1998 - v1
Checksum:i35F73B0765C06BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92006 mRNA Translation: AAB62090.1
RefSeqiNP_001081685.1, NM_001088216.1
UniGeneiXl.185

Genome annotation databases

GeneIDi397997
KEGGixla:397997

Similar proteinsi

Entry informationi

Entry nameiO42598_XENLA
AccessioniPrimary (citable) accession number: O42598
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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