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Protein

ER lumen protein-retaining receptor 3

Gene

kdelr3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 3
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 3
Short name:
KDEL receptor 3
Gene namesi
Name:kdelr3
Synonyms:erd2, kdelr
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865837 kdelr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 214CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941601 – 214ER lumen protein-retaining receptor 3Add BLAST214

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG001398
KOiK10949

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O42580-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIFRILGDV SHLLAIIILL LKMWKSKSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTVFISPYN TVMKIIFLAC AYVTVYLIYG KLRKSYDSEN DTFRLEFLLV
110 120 130 140 150
PVIGLSFLEN YEFTPLEILW TFSIYLESVA ILPQLFMISK TGEAESITTH
160 170 180 190 200
YLFFLGLYRV LYLANWIWRY HTEKFYDQIA VVSGVVQTIF YFDFFYLYVT
210
KVLKGKKLSL PMPV
Length:214
Mass (Da):25,010
Last modified:January 1, 1998 - v1
Checksum:i4E43E467D2B3C6ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001533 mRNA Translation: CAA04817.1
BC054181 mRNA Translation: AAH54181.1
RefSeqiNP_001079763.1, NM_001086294.1
UniGeneiXl.7269

Genome annotation databases

GeneIDi379453
KEGGixla:379453

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001533 mRNA Translation: CAA04817.1
BC054181 mRNA Translation: AAH54181.1
RefSeqiNP_001079763.1, NM_001086294.1
UniGeneiXl.7269

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379453
KEGGixla:379453

Organism-specific databases

CTDi379453
XenbaseiXB-GENE-865837 kdelr3

Phylogenomic databases

HOVERGENiHBG001398
KOiK10949

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERD23_XENLA
AccessioniPrimary (citable) accession number: O42580
Secondary accession number(s): Q5D084
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: January 18, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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