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Protein

Isotocin-neurophysin IT 1

Gene
N/A
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Isotocin causes contraction of smooth muscles.

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Isotocin-neurophysin IT 1
Cleaved into the following 2 chains:
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
PeptideiPRO_000002055420 – 28Isotocin9
ChainiPRO_000002055532 – 155Neurophysin IT 1Add BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 25By similarity
Modified residuei28Glycine amideBy similarity1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 105By similarity
Disulfide bondi99 ↔ 117By similarity
Disulfide bondi106 ↔ 111By similarity

Post-translational modificationi

Seven disulfide bonds are present in neurophysin.By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiO42493

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000039963

Structurei

3D structure databases

ProteinModelPortaliO42493
SMRiO42493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42493-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGTAISVCL LFLLSVCSAC YISNCPIGGK RSIMDAPQRK CMSCGPGDRG
60 70 80 90 100
RCFGPGICCG ESFGCLMGSP ESARCAEENY LLTPCQAGGR PCGSEGGLCA
110 120 130 140 150
SSGLCCDAES CTMDQSCLSE EEGDERGSLF DGSDSGDVIL KLLRLAGLTS

PHQTH
Length:155
Mass (Da):16,026
Last modified:January 1, 1998 - v1
Checksum:iC73432D910141848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90880 Genomic DNA Translation: AAC60289.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90880 Genomic DNA Translation: AAC60289.1

3D structure databases

ProteinModelPortaliO42493
SMRiO42493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000039963

Proteomic databases

PRIDEiO42493

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEUI_TAKRU
AccessioniPrimary (citable) accession number: O42493
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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