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Entry version 138 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Guanylate cyclase

Gene
N/A
Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotationARBA annotation
Biological processcGMP biosynthesisUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanylate cyclaseUniRule annotationARBA annotation (EC:4.6.1.2UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500415837533 – 1055Guanylate cyclaseSequence analysisAdd BLAST1023

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini522 – 795Protein kinaseInterPro annotationAdd BLAST274
Domaini870 – 1000Guanylate cyclaseInterPro annotationAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili807 – 834Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
AAKSEHY

Database of Orthologous Groups

More...
OrthoDBi
229634at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07302, CHD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR001828, ANF_lig-bd_rcpt
IPR001170, ANPR/GUC
IPR011009, Kinase-like_dom_sf
IPR029787, Nucleotide_cyclase
IPR028082, Peripla_BP_I
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00211, Guanylate_cyc, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00255, NATPEPTIDER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit
SSF55073, SSF55073, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O42440-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPGQRMGC RGALGCCLFA ALCFCLLPGC RSNITAAVML PDNYHKYPWA
60 70 80 90 100
LPRVFPALLM AQEDLHTKHK LLLGHTITIL NYSTENPAAP GSCAESRAQV
110 120 130 140 150
VVVDAKLYSR PDVFFGPGCV YPLASVGRFV SHWKLPLITA GGPAYGFEKL
160 170 180 190 200
DEYRTIVRIG PSTTKLGAFV NVLHTQFNWT SRAVVIFYDL KQDDRPHYFL
210 220 230 240 250
SEGIFMNLKD EMNMTVSARP YTNEQDYKEL VSFIKENGRI IYICGPLETF
260 270 280 290 300
LSIMKLFQSE IQDPESYAIF YLDVFAESLT HRKPWQNAKF DWTNPIQVFK
310 320 330 340 350
SVFVITYHPP DNPEYKDFQR KLHARAQRDF GVNLEPSLMD YIAGSFYDGF
360 370 380 390 400
VLYAMALDET LAEGGAQNNG INITRRTQNR SFWGVTGLVS IDKRNARNID
410 420 430 440 450
VDLWAMTNQE TGEYGVVSYY NGSTKEIVWS QTEKIHWPSC GPPLDNPPCV
460 470 480 490 500
FSTDDPSCND GLPVLGIVAV GSGLALIIFG ISSFLIYRKL KLEKELAGML
510 520 530 540 550
WRVQWEDLQF ESPNKYHKRA GSRLTLSQRG SSYGSLITAQ GKYQLFAKTG
560 570 580 590 600
YFKGNLVAIK HVNKKRIELT RQVLMELKHM RDVQFNHLTR FIGACIDPPN
610 620 630 640 650
ICIVTEYCPR GSLQDILENE SINLDWMFRY SLINDIVKGM NFLHNSYFGC
660 670 680 690 700
HGNLKSSNCV VDSRFVLKIT DYGLASFRSS CKNDDSHALY AKKLWTAPEL
710 720 730 740 750
LIYDHHPPQG TQKGDVYSFG IILQEIALRN GPFYVESMDL SPKEIVQKVR
760 770 780 790 800
NGQRPYFRPT TDSRFHSEEL TILMEGCWAE DPAERPDFGH IKIYMAKLNK
810 820 830 840 850
EGSTSILNNL LSRMEQYANN LENLVEERTQ AYLEEKRKAE NLLYQILPHS
860 870 880 890 900
VAEQLKRGET VQAEAFDSVT IYFSDIVGFT SMSAESTPLQ VVTLLNDLYT
910 920 930 940 950
CFDAIIDNFD VYKVDTIADA YMVVSGLPVR NGKLHAREIA SMSLALLEQV
960 970 980 990 1000
KTFKIRHRPN DQLRLRIGIH TGPVCAGVVG LKMPRYCLFG DTVNTASRME
1010 1020 1030 1040 1050
SNGEALKNHV SSATKEVLDE FCYFNLELRG DVEMKGKGKM RTYWLLGEKT

DVYVI
Length:1,055
Mass (Da):119,661
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD89DDD2965005345
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB004921 mRNA Translation: BAA20563.1

NCBI Reference Sequences

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RefSeqi
NP_001098128.1, NM_001104658.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100049183

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ola:100049183

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004921 mRNA Translation: BAA20563.1
RefSeqiNP_001098128.1, NM_001104658.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100049183
KEGGiola:100049183

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4882

Phylogenomic databases

OMAiAAKSEHY
OrthoDBi229634at2759

Family and domain databases

CDDicd07302, CHD, 1 hit
Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR001828, ANF_lig-bd_rcpt
IPR001170, ANPR/GUC
IPR011009, Kinase-like_dom_sf
IPR029787, Nucleotide_cyclase
IPR028082, Peripla_BP_I
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00211, Guanylate_cyc, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PRINTSiPR00255, NATPEPTIDER
SMARTiView protein in SMART
SM00044, CYCc, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit
SSF55073, SSF55073, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO42440_ORYLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42440
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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