Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (03 Jul 2019)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Neurofascin

Gene

NFASC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurofascin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFASC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1235ExtracellularSequence analysisAdd BLAST1210
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1236 – 1256HelicalSequence analysisAdd BLAST21
Topological domaini1257 – 1369CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001504826 – 1369NeurofascinAdd BLAST1344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi64 ↔ 119PROSITE-ProRule annotation
Disulfide bondi163 ↔ 214PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi286 ↔ 334PROSITE-ProRule annotation
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 426PROSITE-ProRule annotation
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi470 ↔ 519PROSITE-ProRule annotation
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi561 ↔ 610PROSITE-ProRule annotation
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi767N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi793N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi853N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi994N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1171N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and O-glycosylated.1 Publication
May be proteolytically cleaved at Arg-636.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei636 – 637Cleavage1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O42414

PRoteomics IDEntifications database

More...
PRIDEi
O42414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

There is one major 'early' isoform and multiple 'late' isoforms. Around 50 isoforms are found at different developmental stages.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O42414 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
680872, 3 interactors

Protein interaction database and analysis system

More...
IntActi
O42414, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000034591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O42414

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 138Ig-like C2-type 1Add BLAST97
Domaini144 – 231Ig-like C2-type 2Add BLAST88
Domaini262 – 350Ig-like C2-type 3Add BLAST89
Domaini355 – 442Ig-like C2-type 4Add BLAST88
Domaini448 – 535Ig-like C2-type 5Add BLAST88
Domaini539 – 626Ig-like C2-type 6Add BLAST88
Domaini645 – 740Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini745 – 838Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini843 – 945Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST103
Domaini949 – 1057Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST109
Domaini1133 – 1222Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1052 – 1126Thr-richAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3513 Eukaryota
ENOG410XSVG LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231380

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O42414

Database of Orthologous Groups

More...
OrthoDBi
434404at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O42414

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.
Isoform 1 (identifier: O42414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLHSHQLTY AGIAFALCLH HLISAIEVPL DSNIQSELPQ PPTITKQSVK
60 70 80 90 100
DYIVDPRDNI FIECEAKGNP VPTFSWTRNG KFFNVAKDPK VSMRRRSGTL
110 120 130 140 150
VIDFHGGGRP DDYEGEYQCF ARNDYGTALS SKIHLQVSRS PLWPKEKVDV
160 170 180 190 200
IEVDEGAPLS LQCNPPPGLP PPVIFWMSSS MEPIHQDKRV SQGQNGDLYF
210 220 230 240 250
SNVMLQDAQT DYSCNARFHF THTIQQKNPY TLKVKTKKPH NETSLRNHTD
260 270 280 290 300
MYSARGVTET TPSFMYPYGT SSSQMVLRGV DLLLECIASG VPAPDIMWYK
310 320 330 340 350
KGGELPAGKT KLENFNKALR ISNVSEEDSG EYFCLASNKM GSIRHTISVR
360 370 380 390 400
VKAAPYWLDE PQNLILAPGE DGRLVCRANG NPKPSIQWLV NGEPIEGSPP
410 420 430 440 450
NPSREVAGDT IVFRDTQIGS SAVYQCNASN EHGYLLANAF VSVLDVPPRI
460 470 480 490 500
LAPRNQLIKV IQYNRTRLDC PFFGSPIPTL RWFKNGQGNM LDGGNYKAHE
510 520 530 540 550
NGSLEMSMAR KEDQGIYTCV ATNILGKVEA QVRLEVKDPT RIVRGPEDQV
560 570 580 590 600
VKRGSMPRLH CRVKHDPTLK LTVTWLKDDA PLYIGNRMKK EDDGLTIYGV
610 620 630 640 650
AEKDQGDYTC VASTELDKDS AKAYLTVLAI PANRLRDLPK ERPDRPRDLE
660 670 680 690 700
LSDLAERSVK LTWIPGDDNN SPITDYIVQF EEDRFQPGTW HNHSRYPGNV
710 720 730 740 750
NSALLSLSPY VNYQFRVIAV NDVGSSLPSM PSERYQTSGA RPEINPTGVQ
760 770 780 790 800
GAGTQKNNME ITWTPLNATQ AYGPNLRYIV RWRRRDPRGS WYNETVKAPR
810 820 830 840 850
HVVWNTPIYV PYEIKVQAEN DFGRAPEPET YIGYSGEDYP KAAPTDVRIR
860 870 880 890 900
VLNSTAIALT WTRVHLDTIQ GQLKEYRAYF WRDSSLLKNL WVSKKRQYVS
910 920 930 940 950
FPGDRNRGIV SRLFPYSNYK LEMVVTNGRG DGPRSEVKEF PTPEGVPSSP
960 970 980 990 1000
RYLRIRQPNL ESINLEWDHP EHPNGVLTGY NLRYQASCLS SPVNGSKTGR
1010 1020 1030 1040 1050
TLVENFSPNQ TRFTVQRTDP ISRYRFFLRA RTQVGDGEVI VEESPALLNE
1060 1070 1080 1090 1100
ATPTPASTWL PPPTTELTPA ATIATTTTTA TPTTETPPTE IPTTAIPTTT
1110 1120 1130 1140 1150
TTTTTTAAST VASTTTTAER AAAATTKQEL ATNGSSIWDI RAWANSNWAN
1160 1170 1180 1190 1200
ITWSHNYSAG TDFVVKYITS NKTEKSIPVK AQTPSSVQLA NLTPGMVYKL
1210 1220 1230 1240 1250
WVFPIWSSPS EHSYITFTTS SAYTKNHVDI ATQGWFIGLM CAIALLVLIL
1260 1270 1280 1290 1300
LIVCFIKRSR GGKYPVRDNK DEHLNPEDKN VEDGSFDYRS LESDEDNKPL
1310 1320 1330 1340 1350
PNSQTSLDGT IKQQESDDSL VDYGEGGEGQ FNEDGSFIGQ YTVKKDKEET
1360
EGNESSEATS PVNAIYSLA
Length:1,369
Mass (Da):152,955
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i835F27D086B2BFF6
GO
Isoform 2 (identifier: O42414-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     987-993: SCLSSPV → F
     1132-1222: Missing.

Show »
Length:1,272
Mass (Da):142,273
Checksum:iBD101CAEAA3E16E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1105T → A in CAA46330 (PubMed:9353344).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008935987 – 993SCLSSPV → F in isoform 2. 1 Publication7
Alternative sequenceiVSP_0089361132 – 1222Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X65224 mRNA Translation: CAA46330.1
Y14341
, Y14342, Y14343, Y14344, Y14345, Y14346, Y14347, Y14348, Y14349, Y14350, Y14351, Y14352, Y14353, Y14354 Genomic DNA Translation: CAA74726.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S26180

NCBI Reference Sequences

More...
RefSeqi
NP_001004493.1, NM_001004493.4 [O42414-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
419824

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65224 mRNA Translation: CAA46330.1
Y14341
, Y14342, Y14343, Y14344, Y14345, Y14346, Y14347, Y14348, Y14349, Y14350, Y14351, Y14352, Y14353, Y14354 Genomic DNA Translation: CAA74726.1
PIRiS26180
RefSeqiNP_001004493.1, NM_001004493.4 [O42414-2]

3D structure databases

SMRiO42414
ModBaseiSearch...

Protein-protein interaction databases

BioGridi680872, 3 interactors
IntActiO42414, 1 interactor
STRINGi9031.ENSGALP00000034591

Proteomic databases

PaxDbiO42414
PRIDEiO42414

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi419824

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
HOGENOMiHOG000231380
InParanoidiO42414
OrthoDBi434404at2759
PhylomeDBiO42414

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O42414

Gene expression databases

ExpressionAtlasiO42414 baseline and differential

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFASC_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42414
Secondary accession number(s): Q90924
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: January 1, 1998
Last modified: July 3, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again