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Protein

Guanine nucleotide-binding protein subunit beta-2-like 1

Gene

gnb2l1

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2-like 1
Alternative name(s):
Receptor of activated protein kinase C
Short name:
RACK
Gene namesi
Name:gnb2l1
Synonyms:rack1
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277371 – 317Guanine nucleotide-binding protein subunit beta-2-like 1Add BLAST317

Proteomic databases

PRIDEiO42249

Interactioni

Protein-protein interaction databases

STRINGi8128.ENSONIP00000016329

Structurei

3D structure databases

ProteinModelPortaliO42249
SMRiO42249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 44WD 1Add BLAST32
Repeati61 – 91WD 2Add BLAST31
Repeati103 – 133WD 3Add BLAST31
Repeati146 – 178WD 4Add BLAST33
Repeati190 – 220WD 5Add BLAST31
Repeati231 – 260WD 6Add BLAST30
Repeati281 – 311WD 7Add BLAST31

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279 Eukaryota
ENOG410XQGZ LUCA
HOVERGENiHBG000277
InParanoidiO42249

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O42249-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEQMTVRGT LKGHSGWVTQ IATTPKYPDM ILSASRDKSI IMWKLTRDET
60 70 80 90 100
NYGIPQRSLK GHSHFVSDVV ISSDGQFALS GAWDGTLRLW DLTTGLTTRR
110 120 130 140 150
FVGHTKDVLS VAFSADNRQI VSGSRDKTIK LWNTLGVCKY TIQDEGHTEW
160 170 180 190 200
VSCVRFSPNS SNPIIVSCGW DKMVKVWNLA NCKLKTNHIG HTGYLNTVTV
210 220 230 240 250
SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DSGDVINALC FSPNRYWLCA
260 270 280 290 300
ATGPSIKIWD LEGKIIVDEL RQEVISTNSK AEPPQCTSLA WSADGQTLFA
310
GYTDNLIRVW QVTIGTR
Length:317
Mass (Da):35,107
Last modified:January 1, 1998 - v1
Checksum:i4DA8360358D9BD99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025331 mRNA Translation: AAB81618.1
RefSeqiNP_001266445.1, NM_001279516.1
UniGeneiOni.25

Genome annotation databases

GeneIDi100534572

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025331 mRNA Translation: AAB81618.1
RefSeqiNP_001266445.1, NM_001279516.1
UniGeneiOni.25

3D structure databases

ProteinModelPortaliO42249
SMRiO42249
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000016329

Proteomic databases

PRIDEiO42249

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100534572

Organism-specific databases

CTDi10399

Phylogenomic databases

eggNOGiKOG0279 Eukaryota
ENOG410XQGZ LUCA
HOVERGENiHBG000277
InParanoidiO42249

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBLP_ORENI
AccessioniPrimary (citable) accession number: O42249
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
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