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Protein

Cochlin

Gene

COCH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell shape and motility in the trabecular meshwork.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cochlin
Alternative name(s):
COCH-5B2
Gene namesi
Name:COCH
Synonyms:COCH5B2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002096720 – 547CochlinAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 46PROSITE-ProRule annotation
Disulfide bondi50 ↔ 70PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42163
PRIDEiO42163

Expressioni

Tissue specificityi

Expressed in inner ear structures; the spindle-shaped cells of the basilar papilla. Weaker expression found in the inferior and superior fibrocartilaginous plates and skeletal muscle.1 Publication

Developmental stagei

Specifically expressed at the late developmental stages in the cochlea.1 Publication

Gene expression databases

BgeeiENSGALG00000009920
ExpressionAtlasiO42163 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi676053, 1 interactor
IntActiO42163, 1 interactor
STRINGi9031.ENSGALP00000037066

Structurei

3D structure databases

ProteinModelPortaliO42163
SMRiO42163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 117LCCLPROSITE-ProRule annotationAdd BLAST94
Domaini162 – 347VWFA 1PROSITE-ProRule annotationAdd BLAST186
Domaini364 – 534VWFA 2PROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR8D Eukaryota
ENOG410XRIU LUCA
HOGENOMiHOG000013195
HOVERGENiHBG005372
InParanoidiO42163
OrthoDBiEOG091G002N
PhylomeDBiO42163

Family and domain databases

Gene3Di2.170.130.20, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR030743 Cochlin
IPR004043 LCCL
IPR036609 LCCL_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44729 PTHR44729, 1 hit
PfamiView protein in Pfam
PF03815 LCCL, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00603 LCCL, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF69848 SSF69848, 1 hit
PROSITEiView protein in PROSITE
PS50820 LCCL, 1 hit
PS50234 VWFA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFAPLLLGV FLLCGSARGS DSSASNAITC FTRGLDLRKE TEDVLCPANC
60 70 80 90 100
PLWQFYVFGD GIYASLSSVC GAAIHRGVIT NAGGAVRVQT LPGQENYPAV
110 120 130 140 150
HANGIQSQVL SRWASSFSVT PGTNNLALEA VGRSVATARP ATGKRPKKTL
160 170 180 190 200
EKKAGNKDCK ADIAFLIDGS YNIGQRRFNL QKNFVGKVAV MLGIGTEGPH
210 220 230 240 250
VGVVQASEHP KIEFYLKNFT AAKEVLFAIK ELGFRGGNSN TGKALKHAAQ
260 270 280 290 300
KFFSMENGAR KGIPKIIVVF LDGWPSDDLE EAGIVAREFG VNVFIVSVAK
310 320 330 340 350
PTTEELGMVQ DIGFIDKAVC RNNGFFSYQM PSWFGTTKYV KPLVQKLCSH
360 370 380 390 400
EQMLCSKTCY NSVNIGFLID GSSSVGESNF RLMLEFISNV AKAFEISDIG
410 420 430 440 450
SKIATVQFTY DQRTEFSFTD YTTKEKVLSA IRNIRYMSGG TATGDAISFT
460 470 480 490 500
TRNVFGPVKD GANKNFLVIL TDGQSYDDVR GPAVAAQKAG ITVFSVGVAW
510 520 530 540
APLDDLKDMA SEPRESHTFF TREFTGLEQM VPDVIRGICK DFLDSKQ
Length:547
Mass (Da):59,427
Last modified:January 1, 1998 - v1
Checksum:i172724242641DF88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012252 mRNA Translation: AAC62253.1
RefSeqiNP_990268.1, NM_204937.1
UniGeneiGga.2805

Genome annotation databases

EnsembliENSGALT00000016132; ENSGALP00000016113; ENSGALG00000009920
GeneIDi395779
KEGGigga:395779

Similar proteinsi

Entry informationi

Entry nameiCOCH_CHICK
AccessioniPrimary (citable) accession number: O42163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 18, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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