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Entry version 145 (12 Aug 2020)
Sequence version 2 (04 May 2001)
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Protein

DNA topoisomerase 2-alpha

Gene

TOP2A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in the regulation of circadian rhythm.By similarity

Miscellaneous

Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.PROSITE-ProRule annotation EC:5.6.2.2

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+PROSITE-ProRule annotation, Mn2+PROSITE-ProRule annotation, Ca2+PROSITE-ProRule annotationNote: Binds two Mg2+ per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn2+ or Ca2+.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei92ATPBy similarity1
Binding sitei121ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi462Magnesium 1; catalyticPROSITE-ProRule annotation1
Metal bindingi542Magnesium 1; catalyticPROSITE-ProRule annotation1
Metal bindingi542Magnesium 2PROSITE-ProRule annotation1
Metal bindingi544Magnesium 2PROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei805Transition state stabilizerBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei806O-(5'-phospho-DNA)-tyrosine intermediateBy similarity1
Sitei857Important for DNA bending; intercalates between base pairs of target DNABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi149 – 151ATPBy similarity3
Nucleotide bindingi162 – 169ATPBy similarity8
Nucleotide bindingi377 – 379ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase
Biological processBiological rhythms
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase 2-alpha (EC:5.6.2.2PROSITE-ProRule annotation)
Alternative name(s):
DNA topoisomerase II, alpha isozyme
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOP2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001453671 – 1553DNA topoisomerase 2-alphaAdd BLAST1553

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O42130

PRoteomics IDEntifications database

More...
PRIDEi
O42130

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei490Interaction with DNAPROSITE-ProRule annotation1
Sitei493Interaction with DNAPROSITE-ProRule annotation1
Sitei662Interaction with DNAPROSITE-ProRule annotation1
Sitei663Interaction with DNAPROSITE-ProRule annotation1
Sitei724Interaction with DNAPROSITE-ProRule annotation1
Sitei758Interaction with DNAPROSITE-ProRule annotation1
Sitei764Interaction with DNAPROSITE-ProRule annotation1
Sitei932Interaction with DNAPROSITE-ProRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000039270

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O42130

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini456 – 573ToprimPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni343 – 345Interaction with DNABy similarity3
Regioni991 – 1000Interaction with DNABy similarity10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II topoisomerase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0355, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O42130

KEGG Orthology (KO)

More...
KOi
K03164

Database of Orthologous Groups

More...
OrthoDBi
117851at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O42130

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00187, TOP4c, 1 hit
cd03365, TOPRIM_TopoIIA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.268.10, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012542, DTHCT
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr
IPR001241, Topo_IIA
IPR013760, Topo_IIA-like_dom_sf
IPR002205, Topo_IIA_A/C
IPR013758, Topo_IIA_A/C_ab
IPR013757, Topo_IIA_A_a_sf
IPR013759, Topo_IIA_B_C
IPR013506, Topo_IIA_bsu_dom2
IPR018522, TopoIIA_CS
IPR031660, TOPRIM_C
IPR006171, TOPRIM_domain
IPR034157, TOPRIM_TopoII

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00204, DNA_gyraseB, 1 hit
PF00521, DNA_topoisoIV, 1 hit
PF08070, DTHCT, 1 hit
PF02518, HATPase_c, 1 hit
PF01751, Toprim, 1 hit
PF16898, TOPRIM_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00433, TOP2c, 1 hit
SM00434, TOP4c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit
SSF56719, SSF56719, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00177, TOPOISOMERASE_II, 1 hit
PS50880, TOPRIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O42130-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLDSPAPL RPLHDNPRLP KADGAQKRLS VERIYQKKTQ LEHILLRPDT
60 70 80 90 100
YIGSVETVTQ QMWVFDEDVG LNCRDVTFVP GLYKIFDEIL VNAADNKQRD
110 120 130 140 150
KSMSCIKVTI DPENNTISVW NNGKGIPVVE HKVEKVYVPA LIFGQLLTSS
160 170 180 190 200
NYDDDEKKVT GGRNGYGAKL CNIFSTKFTV ETACREYKKL FKQTWTDNMG
210 220 230 240 250
KAGEMTLKHF DGEDYTCVTF QPDLSKFKMT ILDKDIVALM SRRAYDIAGS
260 270 280 290 300
TKDVKVFLNG KRLPVKGFRS YVDLYLKDKV DETGNALKVI HEEVNSRWEV
310 320 330 340 350
CLTLSEKGFQ QVSFVNSIAT TKGGRHVDYV ADQIVTKLID VVKKKNKNGV
360 370 380 390 400
GVKPFQVKNH MWIFVNSLIE NPTFDSQTKE NMTLQAKSFG STCKLSEKFI
410 420 430 440 450
KGAVGCGIVE SILNWVKFKA QTQLNKKCSA VKHTKIKGVP KLDDANDAGS
460 470 480 490 500
KNSIDCTLIL TEGDSAKTLA VSGLGVVGRD KYGVFPLRGK MLNVREASHK
510 520 530 540 550
QIMENAEINN IIKIVGLQYK KNYEDRESLK SLRYGKIMIM TDQDQDGSHI
560 570 580 590 600
KGLLINFIHH NWPSLLRHNF LEEFITPIIK VSKNKEEIPF YSIPEFEEWK
610 620 630 640 650
SSTQNYNSWK IKYYKGLGTS TSKEAKEYFA DMARHRIGFK YSGPEDDAAI
660 670 680 690 700
TLAFSKKKVE ERKEWLTNFM EDRRQRNVHG LPEDYLYGKD TNYLTYNDFI
710 720 730 740 750
NKELVLFSNS DNERSIPSLV DGLKPGQRKV LFTCFKRNDK REVKGAQLAG
760 770 780 790 800
SVAEMSSYHH GEASLMMTII NLAQNFVGSN NLNLLQPIGQ FGTRLHGGKD
810 820 830 840 850
SASPRYIFTM LSPLARLLFP PVDDNVLRFL YDDNQRVEPE WYMPIIPMVL
860 870 880 890 900
INGAEGIGTG WSCKIPNFDI RETVNNIRCL LDGKEPLPML PSYKNFKGTI
910 920 930 940 950
DELGPNQYVI SGEVSILDST TIEITELPVR TWTQTYKEQV LEPMLNGTEK
960 970 980 990 1000
TPPLITDYKE YHTDTTVKFV VKMSEEKLAE AEAVGLHKVF KLQTNLTCNS
1010 1020 1030 1040 1050
MVLFDHVGFL KKYESPQDIL KEFFELRLRY YGLRKEWLIG MLGAESAKLN
1060 1070 1080 1090 1100
NQARFILEKI DGKIVIENKP KKELIQVLIQ RGYESDPVKA WKELQNKEEE
1110 1120 1130 1140 1150
EGDESGEESA AATGPDFNYL LNMPLWYLTK EKKDELCKQR DNKDKELEDL
1160 1170 1180 1190 1200
KHKSPSDLWK EDLAAFVEEL DAVEAKQMQD EMAGITGKPL KVKGGKQGGK
1210 1220 1230 1240 1250
QKVTKAQLAE VMPSPHGIRV VPRVTAEMKA EAEKRIKKKI KSEKNESDEK
1260 1270 1280 1290 1300
QEGNSSGDKE PSSLKQRLAQ KRKAEQGTKR QTTLPFKPIK KMKRNPWSDS
1310 1320 1330 1340 1350
ESDSESDDFE VPSKRERVVR QAAAKIKPMV NSDSDADLTS SDEDSEYQEN
1360 1370 1380 1390 1400
SEGNTDSDTT SKKKPPKAKA VPKEKKGKAP KEKPLPDAVP VRVQNVAAES
1410 1420 1430 1440 1450
ASQDPAAPPV SVPRAQAVPK KPAAAKKGST AKDNQPSIMD ILTKKKAAPK
1460 1470 1480 1490 1500
APRRAQREES PPSEATAAVA KKPGPPRGRK ATKRLTSSSD SDSDFGSRPS
1510 1520 1530 1540 1550
KSVAAKKSKR DDDDSYSIDL TADSPAAAAP RTRPGRLKKP VQYLESSDED

DMF
Length:1,553
Mass (Da):174,993
Last modified:May 4, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3322CE95238F71B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007445 mRNA Translation: BAA22539.2

NCBI Reference Sequences

More...
RefSeqi
NP_990122.1, NM_204791.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395570

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007445 mRNA Translation: BAA22539.2
RefSeqiNP_990122.1, NM_204791.1

3D structure databases

SMRiO42130
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039270

Proteomic databases

PaxDbiO42130
PRIDEiO42130

Genome annotation databases

GeneIDi395570
KEGGigga:395570

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7153

Phylogenomic databases

eggNOGiKOG0355, Eukaryota
InParanoidiO42130
KOiK03164
OrthoDBi117851at2759
PhylomeDBiO42130

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O42130

Family and domain databases

CDDicd00187, TOP4c, 1 hit
cd03365, TOPRIM_TopoIIA, 1 hit
Gene3Di1.10.268.10, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit
InterProiView protein in InterPro
IPR012542, DTHCT
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr
IPR001241, Topo_IIA
IPR013760, Topo_IIA-like_dom_sf
IPR002205, Topo_IIA_A/C
IPR013758, Topo_IIA_A/C_ab
IPR013757, Topo_IIA_A_a_sf
IPR013759, Topo_IIA_B_C
IPR013506, Topo_IIA_bsu_dom2
IPR018522, TopoIIA_CS
IPR031660, TOPRIM_C
IPR006171, TOPRIM_domain
IPR034157, TOPRIM_TopoII
PfamiView protein in Pfam
PF00204, DNA_gyraseB, 1 hit
PF00521, DNA_topoisoIV, 1 hit
PF08070, DTHCT, 1 hit
PF02518, HATPase_c, 1 hit
PF01751, Toprim, 1 hit
PF16898, TOPRIM_C, 1 hit
SMARTiView protein in SMART
SM00433, TOP2c, 1 hit
SM00434, TOP4c, 1 hit
SUPFAMiSSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit
SSF56719, SSF56719, 1 hit
PROSITEiView protein in PROSITE
PS00177, TOPOISOMERASE_II, 1 hit
PS50880, TOPRIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOP2A_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O42130
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 4, 2001
Last modified: August 12, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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