Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine 3-monooxygenase

Gene

th

Organism
Anguilla anguilla (European freshwater eel) (Muraena anguilla)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the physiology of adrenergic neurons.By similarity

Catalytic activityi

L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.

Cofactori

Enzyme regulationi

Phosphorylation leads to an increase in the catalytic activity.By similarity

Pathwayi: dopamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (th)
  2. no protein annotated in this organism
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi321IronBy similarity1
Metal bindingi326IronBy similarity1
Metal bindingi366IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processCatecholamine biosynthesis, Neurotransmitter biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00747; UER00733

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine 3-monooxygenase (EC:1.14.16.2)
Alternative name(s):
Tyrosine 3-hydroxylase
Short name:
TH
Gene namesi
Name:th
OrganismiAnguilla anguilla (European freshwater eel) (Muraena anguilla)
Taxonomic identifieri7936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055591 – 488Tyrosine 3-monooxygenaseAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliO42091
SMRiO42091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006841

Family and domain databases

Gene3Di1.10.800.10, 1 hit
InterProiView protein in InterPro
IPR001273 ArAA_hydroxylase
IPR018301 ArAA_hydroxylase_Fe/CU_BS
IPR036951 ArAA_hydroxylase_sf
IPR036329 Aro-AA_hydroxylase_C_sf
IPR019774 Aromatic-AA_hydroxylase_C
IPR005962 Tyr_3_mOase
IPR019773 Tyrosine_3-monooxygenase-like
IPR021164 Tyrosine_hydroxylase_CS
PANTHERiPTHR11473 PTHR11473, 1 hit
PfamiView protein in Pfam
PF00351 Biopterin_H, 1 hit
PF12549 TOH_N, 1 hit
PIRSFiPIRSF000336 TH, 1 hit
PRINTSiPR00372 FYWHYDRXLASE
SUPFAMiSSF56534 SSF56534, 1 hit
TIGRFAMsiTIGR01269 Tyr_3_monoox, 1 hit
PROSITEiView protein in PROSITE
PS00367 BH4_AAA_HYDROXYL_1, 1 hit
PS51410 BH4_AAA_HYDROXYL_2, 1 hit

Sequencei

Sequence statusi: Complete.

O42091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPISNSSGSS TKSITRAGSE LDRADSITSP RFVGRRQSLI EDARKEREAA
60 70 80 90 100
AAAESSEASE QIVFDEEDGK ALLNLFFTLR SSKIPALSRA LKVFETFEAK
110 120 130 140 150
IHHLETRTRR KPKDSLEDLE YFVRCEVHLA DVSTLISSIR RIAEDVRTTK
160 170 180 190 200
EVKFHWFPKK ISELDSCHHL VTKFDPDLDQ DHPGFTDPVY RQRRRMIGEI
210 220 230 240 250
AFRYKHGEPI PRVEYTEEEI GTWREVYSTL RDLYTTHACS EHLEAFRLLE
260 270 280 290 300
RHCGYSPNSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ
310 320 330 340 350
CTQYIRHASS PMHSPEPDCV HELLGHVPML ADRTFAQFSQ NIGLASLGAS
360 370 380 390 400
EEDIEKLSTL YWFTVEFGLC KQGDGVKAYG AGLLSSYGEL VHSLSDEPER
410 420 430 440 450
REFDPEAAAA EPYQDQNYQS VYFVSESFTD AKEKLRVYAA GINRPFSVRF
460 470 480
DPYTYSIEVL DNPLKIRGGL ESVKDELKVL TDALNVLA
Length:488
Mass (Da):55,490
Last modified:January 1, 1998 - v1
Checksum:i573553BA39EBD448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000731 mRNA Translation: CAA04264.1

Similar proteinsi

Entry informationi

Entry nameiTY3H_ANGAN
AccessioniPrimary (citable) accession number: O42091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health