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Entry version 65 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Large tegument protein deneddylase

Gene

ORF64

Organism
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.

UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei20Important for catalytic activityUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei33UniRule annotation1
Active sitei163UniRule annotation1
Active sitei165UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processHost-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Large tegument protein deneddylaseUniRule annotation (EC:3.4.19.12UniRule annotation, EC:3.4.22.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri33708 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiApodemus sylvaticus (European woodmouse) [TaxID: 10129]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000099649 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000175018 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004069151 – 2457Large tegument protein deneddylaseAdd BLAST2457

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O41965

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.

Interacts with inner tegument protein.

Interacts with capsid vertex specific component CVC2.

Interacts with the major capsid protein/MCP.

UniRule annotation

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-47224N

Protein interaction database and analysis system

More...
IntActi
O41965, 1 interactor

Molecular INTeraction database

More...
MINTi
O41965

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O41965

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 224Peptidase C76UniRule annotationAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 234Deubiquitination activityUniRule annotationAdd BLAST234
Regioni281 – 350DisorderedSequence analysisAdd BLAST70
Regioni2064 – 2131DisorderedSequence analysisAdd BLAST68
Regioni2164 – 2360DisorderedSequence analysisAdd BLAST197
Regioni2387 – 2407DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi281 – 298Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi314 – 336Acidic residuesSequence analysisAdd BLAST23
Compositional biasi2093 – 2113Polar residuesSequence analysisAdd BLAST21
Compositional biasi2114 – 2131Pro residuesSequence analysisAdd BLAST18
Compositional biasi2169 – 2192Polar residuesSequence analysisAdd BLAST24
Compositional biasi2208 – 2222Polar residuesSequence analysisAdd BLAST15
Compositional biasi2300 – 2333Basic and acidic residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae large tegument protein family.UniRule annotation

Keywords - Domaini

Repeat

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04044, HSV_LTP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04843, Herpes_teg_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51521, HTUSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O41965-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPASLAGF RIEGTASTNQ ADCKFGENAG AQCLSNCIIY LMSSYFNNEA
60 70 80 90 100
PITETHDLNK VLKFGAELDS NLRKLGLLSP GQYAQLDHVP CYVQTRKWSG
110 120 130 140 150
FIYTSAEMFG LLGMPADISD SCITSLRDLL TANYSNTIQY ILYICGQKSG
160 170 180 190 200
AIIIQGGRYT MFDPHCLKDI PESPAHVLST SDPDALIKYV GGVSREYTAC
210 220 230 240 250
FLYFVPGHIS PKNYIMSHYK VISFSDLHGS KIILEEYDLP TTNQSFCSSP
260 270 280 290 300
QASSSPDPEV GSLLKYMSKA KRKRYPMSCG EEWTDANKKR KESGRTPPEK
310 320 330 340 350
MTHPLPSPDI IDLTMDDDVI DLTGDDDMED ESEGDREAEP DRSGTSLPSV
360 370 380 390 400
TLPNLAAVDQ LLNSLTLPGH VPSFPALVDT DTGESYRLTR ALHQLKNVLQ
410 420 430 440 450
QVLEIGVVSD SDYTPTEALN VLNYLMAWSK QLQIKNDDIK LLINSNLQIE
460 470 480 490 500
KLFTLLKNNL ISDPNLADHV QAKVCACLPA MHANRATDLQ KILLHCKNLT
510 520 530 540 550
RALEISKSSL DIKDIITTFT ESFPQDFFCV CSVEEANNLV STVQDLKRVV
560 570 580 590 600
SNNMALTSEQ DARFKALMLS VLNNTDPPAS LGPIYLETET RTPLLSSAIQ
610 620 630 640 650
EAVKAIEKDT VETLSELISN IPSENAIETT FVPPVRTLLK NVTTLLTVIN
660 670 680 690 700
ACVERAEIRT PEIDSSQQQL SYIGRELSKI IDETWPERAF REPVHVLDIF
710 720 730 740 750
QKTSSHLNDL KKKMADSESL DKILSEINQT LKAIQDKAAS PALINTLSDY
760 770 780 790 800
IKNATVLAQA SDPRLVEIQS QVTTLTTSTS YIESLLQKIN IRTLPEVIPQ
810 820 830 840 850
LQAATKTEQG QLSLAAMNLS LIQITNSLIN EALSSIHARS HNHLSNTFFN
860 870 880 890 900
SLNSLMGLAD IPGREDLIKT MESIMAVQEE LVDCDDMECV EKGLTTFKYI
910 920 930 940 950
KSSIRQYKFD KSFKTKIYLI ITSEVRDLTK IKTDKQLEAW KQDVADFTPA
960 970 980 990 1000
SIDDLNLFLD KAPTKTARSY ATRQLKHFRD DLIKEQEMET ETTPVPSTAE
1010 1020 1030 1040 1050
IERAIDLKIK ATWDKILTNL RDLTFHHIAP GDWQVLLTVF NDHKSALFTK
1060 1070 1080 1090 1100
MGGELLKALQ GLTAYVDSIL TPLLASQLPQ GQRYVAPNSD WVETFDQNVK
1110 1120 1130 1140 1150
YYLRTFHLPR VSEQLDDLER KTLLLTKLVK FTDLSQSLIG THLEKDWSIY
1160 1170 1180 1190 1200
QKLFNSLLTV YNDHLIKTKT EVHAFLDKIA SDPLLEPQAH PDLQKITQLF
1210 1220 1230 1240 1250
TEQEIIEINT LPDIFKESIK NNEKHYIASY QTEMKVFTSM VDAALAKKTQ
1260 1270 1280 1290 1300
STTEYNTHLL KIVNNMLVQA PPYAASHPIS SDAISYITSL VRDKHLLEKL
1310 1320 1330 1340 1350
SYAESLKNFN WLSRLITIIL TNCHPSHKQH LQTLLDEILS REQTLTPLVA
1360 1370 1380 1390 1400
LEDNANQSPT ERTLQAALTT LNVERVLGRA TTFQKWKSQL QELEEAVKTT
1410 1420 1430 1440 1450
TQVSLLIQTI SSLHDKTVTE MDPTILSSHS QALADKLKEL LALKPSLDET
1460 1470 1480 1490 1500
TMSLFHGMKA YAQFKHYFVQ HYVITQPKIF DAYPLSHHGT VSSSGGHQAT
1510 1520 1530 1540 1550
KFNPLMRLKA FSMVTDVKKM SVWREINTTV DPTGHTFIPA PPTPAMPPIH
1560 1570 1580 1590 1600
YNVLFSSFLQ AEAINLALNS NQPPTKKFGL LPGLMDARVG VQGAMLLDNQ
1610 1620 1630 1640 1650
WNDISTNSAK LLDHYVRSEL TPNSLTNSQF AAMTVFAHAM AMVTPHINST
1660 1670 1680 1690 1700
RATIFPSKAI VLNQLQFLKL CLTMWPKFSG GLLRAPSFER VVQLARATLP
1710 1720 1730 1740 1750
TLLLSAPRNT LNHFLANNYR PTDTLPNTEA LLFYPNQHPL VNLEKLLLTS
1760 1770 1780 1790 1800
SPFHALSTSV LNTRISMLVW GILSLSEAVL QQLWDSLYQE SATFTTYIDL
1810 1820 1830 1840 1850
LRHLSAMNHK NSTLTTSTSL PQNNGPVVYS YGHTAGTTVA TLEGSHPLDD
1860 1870 1880 1890 1900
GGQNIPMTLF EFVIFAIILK LKFHVFYTQE KALVNTQLGP LHLITHALDG
1910 1920 1930 1940 1950
TGDTEPFKTY ISIPPQKYNG LGNLQQFCSQ DEIQIFQRQH EWLVGVTKQT
1960 1970 1980 1990 2000
SFSNEDLFIV LASADNKVLS VHTFNPPINS LESETPEIVA APIQESWPKE
2010 2020 2030 2040 2050
ITTVSFWDKP ALEKSPQELI TEVSLVAEIF SGSAIFNTFP PSYKMVSHTP
2060 2070 2080 2090 2100
SLHVETHQLE NLSITEGTPP TSPPLPDSTT QDHMEEPDNK QAKPPYQMTS
2110 2120 2130 2140 2150
PMKENTSTSG RPARSPSPSP PVLTPIKPII PIPQATPTMP ILSPFTPRLL
2160 2170 2180 2190 2200
PAAVKKHQNG AVWGHSGSLP PTHIQSSTPG PAQNTRDSGR RQIVSPVITI
2210 2220 2230 2240 2250
LPGTKAGADS AGQNTSHKDI SAYSPPPASK KTDRPSDTHV TAPLFSKSKL
2260 2270 2280 2290 2300
VTPRPAAKTD TGTFGPLLGH EKPPVTDLTA PVEPGHPSKV SPIIHLKPSN
2310 2320 2330 2340 2350
TGDRDPHPIS DDEDSKQPPV PDTSRDKAQS RWKTPKQRPQ NIFPPPKHED
2360 2370 2380 2390 2400
DVPVTAPQPQ GRKILVGGRQ LPSLVYNPPT LRDIKTGMSD DKNPEPCVKE
2410 2420 2430 2440 2450
NPPGVTHDPP LRIQHMEQTV NSSKYNVLLF IEKIIKSVHD HSSYMLSTLK

RIKQLYI
Length:2,457
Mass (Da):273,538
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AE1D5E1821BAAD1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U97553 Genomic DNA Translation: AAB66417.1
AF105037 Genomic DNA Translation: AAF19328.1

NCBI Reference Sequences

More...
RefSeqi
NP_044902.1, NC_001826.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1497174

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1497174

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97553 Genomic DNA Translation: AAB66417.1
AF105037 Genomic DNA Translation: AAF19328.1
RefSeqiNP_044902.1, NC_001826.2

3D structure databases

SMRiO41965
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-47224N
IntActiO41965, 1 interactor
MINTiO41965

Proteomic databases

PRIDEiO41965

Genome annotation databases

GeneIDi1497174
KEGGivg:1497174

Family and domain databases

HAMAPiMF_04044, HSV_LTP, 1 hit
InterProiView protein in InterPro
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF04843, Herpes_teg_N, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51521, HTUSP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTP_MHV68
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O41965
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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