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UniProtKB - O36979 (POLG_ZYMVS)

Entry version 139 (07 Oct 2020)
Sequence version 2 (19 Dec 2001)
Previous versions | rss
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Protein

Genome polyprotein

Gene
N/A
Organism
Zucchini yellow mosaic virus (strain Singapore) (ZYMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei267For P1 proteinase activityBy similarity1
Active sitei655For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei728For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2090For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2125For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2195For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1252 – 1259ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...MEROPSi		C06.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
Protein P3
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Viral genome-linked protein
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZucchini yellow mosaic virus (strain Singapore) (ZYMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri117130 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Stelpaviricetes › Patatavirales › Potyviridae › Potyvirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCitrullus lanatus (Watermelon) (Citrullus vulgaris) [TaxID: 3654]
Cucumis melo (Muskmelon) [TaxID: 3656]
Cucumis sativus (Cucumber) [TaxID: 3659]
Cucurbita pepo (Vegetable marrow) (Summer squash) [TaxID: 3663]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008612 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200371 – 3083Genome polyproteinAdd BLAST3083
ChainiPRO_00000405201 – 313P1 proteinaseSequence analysisAdd BLAST313
ChainiPRO_0000040521314 – 769Helper component proteinaseSequence analysisAdd BLAST456
ChainiPRO_0000040522770 – 1115Protein P3By similarityAdd BLAST346
ChainiPRO_00000405231116 – 11676 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000405241168 – 1801Cytoplasmic inclusion proteinBy similarityAdd BLAST634
ChainiPRO_00000405251802 – 18546 kDa protein 2By similarityAdd BLAST53
ChainiPRO_00000405261855 – 2044Viral genome-linked proteinBy similarityAdd BLAST190
ChainiPRO_00000405272045 – 2287Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_00000405282288 – 2804Nuclear inclusion protein BBy similarityAdd BLAST517
ChainiPRO_00000405292805 – 3083Capsid proteinBy similarityAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1918O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei313 – 314Cleavage; by P1 proteinaseSequence analysis2
Sitei769 – 770Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1115 – 1116Cleavage; by NIa-proBy similarity2
Sitei1167 – 1168Cleavage; by NIa-proBy similarity2
Sitei1801 – 1802Cleavage; by NIa-proBy similarity2
Sitei2044 – 2045Cleavage; by NIa-proBy similarity2
Sitei2287 – 2288Cleavage; by NIa-proBy similarity2
Sitei2804 – 2805Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		O36979

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 313Peptidase S30PROSITE-ProRule annotationAdd BLAST141
Domaini647 – 769Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1239 – 1391Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1410 – 1569Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2045 – 2263Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini2529 – 2653RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi365 – 368Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi621 – 623Involved in virions binding and aphid transmissionBy similarity3
Motifi1341 – 1344DECH box4
Motifi1894 – 1903Nuclear localization signalSequence analysis10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potyviridae genome polyprotein family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: O36979-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAIMIGSIS VPIIGSAQCA TAPIGNRVNI VAPGHMAICK PQMRSHAYYK 
        60         70         80         90        100
HASQKLSEQS SRGIEVLNSF FNNDPEDAFR LTRNGMSKVK KGPNGRIILR 
       110        120        130        140        150
KPKARHVFER INLEKSEKEQ KGKFFNGEYD TTVTSIKGVT TSKENDLGAF 
       160        170        180        190        200
SLRSPFYKRT CKKEKRRITR ENIVCVDDVN NLCERILKIT RDKNIPVEII 
       210        220        230        240        250
GKRRNHHTLT FKKFKGSFVG KVSLAPERSQ MKHVEMSYGQ FDYILQAICR 
       260        270        280        290        300
ITSTKHVRDE DIKPGCSGWV FSTDHALTQK YSRLPYLVIR GRDDDGIVNA 
       310        320        330        340        350
LEPVLFYSDV EHYSFQNEVQ FFNGWRKMFD KLKPHSDHTC KVDHNNEECG 
       360        370        380        390        400
EMAAVLSQAI FPVLKLSCQV CREKLSRVSF EEFKDFLSRN FMTHESEWST 
       410        420        430        440        450
LRDGVHCDNV LKLIKGAVQT TQNLKLSSDI MKLVQNHTST HMKQIQDINK 
       460        470        480        490        500
ALMKGSLVTQ DELDLALKQL LEMTQWFKNH MHLTGEEALK TFRNKRSNKA 
       510        520        530        540        550
MINPSLLCDN QLDKNGNFIW GERGYHSKRL FKNFFEEVIP SEGYTKYIVR 
       560        570        580        590        600
NFPNGTRKLA IGSLIVPLNL DRARTALLGE SIEKEPLTSA CISQQNENYI 
       610        620        630        640        650
HSCCCVTMDD GTPMYSELKS PTKRHLVIGA SGDPKYIDLP ASEAERMYIA 
       660        670        680        690        700
KEGYCYLNIF LAMLVNVNEN EAKDFTKMIR DVLIPMLGQW PSLMDVATAA 
       710        720        730        740        750
YILGVFHPET RCAELPRILV DHATQTMHVI DSYGSLTVGY HVLKAGTVNH 
       760        770        780        790        800
LIQFASNDLQ SEMKHYRVGG TPTQRIRLEE QLIKGIFKPK IMMQLLHDDP 
       810        820        830        840        850
YILLLGMISP TILVHMYRMR HFERGIEIWI KRDHEIGKIF VILEQLTRKV 
       860        870        880        890        900
ALAEILVDQL DLISEASPHL LEIMNGCQDN QRAYAPALDL LTIQVEREFS 
       910        920        930        940        950
NKELKTNGYP DLHQTLHDMR EKMYAKQLHN SWQELSLLEK SCVTVRLKQF 
       960        970        980        990       1000
SIFTERNLTQ RAKERKHASS LQFVHECFIT TRVHAKSIRD AGVRKLNEAL 
      1010       1020       1030       1040       1050
VGTCKFFFSC GFRIFARCYS DIIYFVNVCL VFSLVLQMSN TVRNMIAATR 
      1060       1070       1080       1090       1100
EEKERAMANK ADENERTLMH MYHIFCKKQD DAPIYNDFLE HVRSVRPDLE 
      1110       1120       1130       1140       1150
ETLLYMAGGE VVTAQAKSAV QIQFEKIIAV LALLTMCFDA ERSDAIFKIL 
      1160       1170       1180       1190       1200
TKLKIVFGTV GETVRLQGLE DIENLEDDKR LTIDFDINTN EAQSSTTFDV 
      1210       1220       1230       1240       1250
HFEDWWNRQL QQNRTVPHYR TTGKFLEFTR STAAYVANEI ASSSEGEFLV 
      1260       1270       1280       1290       1300
RGAVGSGKST SLPAHLAKKG KVLLLEPTRP LAENVSRQLA GDPFFQNVTL 
      1310       1320       1330       1340       1350
RMRGLSCFGS SNITVMTSGF AFHYYVNNPH QLMEFDFVII DECHVTDSAT 
      1360       1370       1380       1390       1400
IAFNCALKEY SFAGKLIKVS ATPPGRECDF DTQFAVKVKT EDHLSFNAFV 
      1410       1420       1430       1440       1450
GAQKTGSNAD MVQHGNNILV YVASYNEVDM LSKLLTERQF SVTKVDGRTM 
      1460       1470       1480       1490       1500
QLGKTTIETH GTSQKPHFIV ATNIIENGVT LDVECVVDFG LKVVAELDSE 
      1510       1520       1530       1540       1550
KRCVRYSKKP VSYGERIQRL GRVGRSKPGT ALRIGHTEKG IENIPEFIAT 
      1560       1570       1580       1590       1600
EAAALSFAYG LSVTTHGVST NNLGKCTVKQ MKCALNFELT PFFTTHLIRH 
      1610       1620       1630       1640       1650
DGSMHPLIHE ELKQFKLRDS EMVLNKVALP HQFVSQWMDQ SEYERIGVHI 
      1660       1670       1680       1690       1700
QCHESTRIPF YTNGIPDKVY ERIWKCIQEN KNDALFGKLS SAFPSKVSYT 
      1710       1720       1730       1740       1750
LSTDPAALPR TIAIIDHLLA EEMMKRNHFD MISSAVTGYS FSLAGIADSF 
      1760       1770       1780       1790       1800
RKRYMRDHTA HHIAILQQAR AQLLEFNSKN VNINNLSDLE GIGVIKSVVL 
      1810       1820       1830       1840       1850
QSKQEVSSFL GLRGKWDGRK FANDVILAVM TLFGGGWFMW EYFTKKVNEP 
      1860       1870       1880       1890       1900
VRVESKKRRS QKLKFRDAYD RKVGREIFGD NDTIGRTFGE AYTKRGKVKG 
      1910       1920       1930       1940       1950
NNSTKGMGRK TRNFVHLYGV EPEIYSFIRF VDPLTGHTLD ESTHTDISLV 
      1960       1970       1980       1990       2000
QEEFGNIREK FLENDLISRQ SIINKPGIQA YFMGKGTEEA LKVDLTPHVP 
      2010       2020       2030       2040       2050
LLLCRNTNAI AGYPERENEL RQTGTPIKVS FKEVPEKNEH VELESKSIYK 
      2060       2070       2080       2090       2100
GVRDYNGIST IVCQLTNDSD GLKETMYGIG YGPIIITNGH LFRKNNGTLL 
      2110       2120       2130       2140       2150
VRSWHGEFTV KNTTTLKVHF IEGKDVVLVR MPKDFPPFRS NASFRAPKRE 
      2160       2170       2180       2190       2200
ERACLVGTNF QEKSLRSTVS ESSMTIPEGT GSYWIHWIST NEGDCGLPMV 
      2210       2220       2230       2240       2250
STTDGKIIGI HGLASTVSSK NYFVPFTDDL LTTHLSKLDD LTWTQHWLWQ 
      2260       2270       2280       2290       2300
PSKIAWGSLN LVDEQPGPEF RISNLVKDLL TSGVETQSKR ERWVYESCEG 
      2310       2320       2330       2340       2350
NLRAVGSAQS ALVTKHVVKG KCPFFEEYLQ THAEANTYFR PLMGEYQPSK 
      2360       2370       2380       2390       2400
LNKEAFKKDF FKYNKPVVVN QLDHDKFLGA VNGVIRMMCD FEFNECRFIT 
      2410       2420       2430       2440       2450
DPEEIYDSLN MKAAIGAQYR GKKKEYFEGL DNFDRERLLF QSCERLFNGH 
      2460       2470       2480       2490       2500
KGLWNGSLKA ELRPLEKVQA NKTRTFTAAP IDTLLGAKVC VDDFNNEFYS 
      2510       2520       2530       2540       2550
KNLKCPWTVG MTKFYGGWDK LMRELPDGWL YCHADGSQFD SSLTPALLNA 
      2560       2570       2580       2590       2600
VLIIRSFYME DWWVGQEMLE NLYAEIVYTP ILAPDGTIFK KFRGNNSGQP 
      2610       2620       2630       2640       2650
STVVDNTLMV VISIYYACMK FGWSYEEIEN KLVFFANGDD LILAVKDEDS 
      2660       2670       2680       2690       2700
GLLDNMSASF SELGLNYDFS ERTHKREDLW FMSHQAMLVD GMYIPKLEKE 
      2710       2720       2730       2740       2750
RIVSILEWDR SKEIMHRTEA ICAAMIEAWG HTDLLREIRK FYLWFVEKEE 
      2760       2770       2780       2790       2800
VRELATLGKA PYIAETALRK LYTDKGAETG ELARYLQALH QDIFFEQGDT 
      2810       2820       2830       2840       2850
VMLQSDTQTR EAGAGASKKD KDEDKDKKKD VASSSASEKA VATATKDKDV 
      2860       2870       2880       2890       2900
NAGSHGKIVP RLSKITKKMS LPRVKGSVIL DIDHLLEYKP DQIELYNTRA 
      2910       2920       2930       2940       2950
SHQQFASWFN QVKAEYDLNE QQMGVVMNGF MVWCIENGTS PDINGVWVMM 
      2960       2970       2980       2990       3000
DGNEQVEYPL KPIVENAKPT LRQIMHHFSD AAEAYIEMRN AEAPYMPRYG 
      3010       3020       3030       3040       3050
LLRNLRDRSL ARYAFDFYEV NSKTPDRARE AVAQMKAAAL SNVSSRLFGL 
      3060       3070       3080 
DGNVATTSED TERHTARDVN RNMHTLLGVN TMQ
Note: Produced by conventional translation.
Length:3,083
Mass (Da):351,033
Last modified:December 19, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4B6C53C14524A88
GO
Isoform P3N-PIPO polyprotein (identifier: P0CK15-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CK15.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:997
Mass (Da):114,071
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF014811 Genomic RNA Translation: AAB72004.2

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014811 Genomic RNA Translation: AAB72004.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiC06.001

Proteomic databases

PRIDEiO36979

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_ZYMVS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O36979
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 19, 2001
Last modified: October 7, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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