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Entry version 96 (18 Sep 2019)
Sequence version 1 (01 Jan 1998)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Human respiratory syncytial virus B (strain B1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N7-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56)
mRNA guanylyltransferase (EC:2.7.7.-)
GDP polyribonucleotidyltransferase (EC:2.7.7.88)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman respiratory syncytial virus B (strain B1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri79692 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaHaploviricotinaMonjiviricetesMononegaviralesPneumoviridaeOrthopneumovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000180717 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000002472 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003657861 – 2166RNA-directed RNA polymerase LAdd BLAST2166

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O36635

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with protein P.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O36635

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini693 – 877RdRp catalyticPROSITE-ProRule annotationAdd BLAST185
Domaini1820 – 2008Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST189

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxovirus L protein family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003006 Ig/MHC_CS
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04198 paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00290 IG_MHC, 1 hit
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O36635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPIINGNSA NVYLTDSYLK GVISFSECNA LGSYLFNGPY LKNDYTNLIS
60 70 80 90 100
RQSPLLEHMN LKKLTITQSL ISRYHKGELK LEEPTYFQSL LMTYKSMSSS
110 120 130 140 150
EQIATTNLLK KIIRRAIEIS DVKVYAILNK LGLKEKDRVK PNNNSGDENS
160 170 180 190 200
VLTTIIKDDI LSAVESNQSY TNSDKNHSVN QNITIKTTLL KKLMCSMQHP
210 220 230 240 250
PSWLIHWFNL YTKLNNILTQ YRSNEVKSHG FILIDNQTLS GFQFILNQYG
260 270 280 290 300
CIVYHKGLKK ITTTTYNQFL TWKDISLSRL NVCLITWISN CLNTLNKSLG
310 320 330 340 350
LRCGFNNVVL SQLFLYGDCI LKLFHNEGFY IIKEVEGFIM SLILNITEED
360 370 380 390 400
QFRKRFYNSM LNNITDAAIK AQKNLLSRVC HTLLDKTVSD NIINGKWIIL
410 420 430 440 450
LSKFLKLIKL AGDNNLNNLS ELYFLFRIFG HPMVDERQAM DAVRINCNET
460 470 480 490 500
KFYLLSSLST LRGAFIYRII KGFVNTYNRW PTLRNAIVLP LRWLNYYKLN
510 520 530 540 550
TYPSLLEITE NDLIILSGLR FYREFHLPKK VDLEMIINDK AISPPKDLIW
560 570 580 590 600
TSFPRNYMPS HIQNYIEHEK LKFSESDRSR RVLEYYLRDN KFNECDLYNC
610 620 630 640 650
VVNQSYLNNS NHVVSLTGKE RELSVGRMFA MQPGMFRQIQ ILAEKMIAEN
660 670 680 690 700
ILQFFPESLT RYGDLELQKI LELKAGISNK SNRYNDNYNN YISKCSIITD
710 720 730 740 750
LSKFNQAFRY ETSCICSDVL DELHGVQSLF SWLHLTIPLV TIICTYRHAP
760 770 780 790 800
PFIKDHVVNL NEVDEQSGLY RYHMGGIEGW CQKLWTIEAI SLLDLISLKG
810 820 830 840 850
KFSITALING DNQSIDISKP VRLIEGQTHA QADYLLALNS LKLLYKEYAG
860 870 880 890 900
IGHKLKGTET YISRDMQFMS KTIQHNGVYY PASIKKVLRV GPWINTILDD
910 920 930 940 950
FKVSLESIGS LTQELEYRGE SLLCSLIFRN IWLYNQIALQ LRNHALCNNK
960 970 980 990 1000
LYLDILKVLK HLKTFFNLDS IDMALSLYMN LPMLFGGGDP NLLYRSFYRR
1010 1020 1030 1040 1050
TPDFLTEAIV HSVFVLSYYT GHDLQDKLQD LPDDRLNKFL TCVITFDKNP
1060 1070 1080 1090 1100
NAEFVTLMRD PQALGSERQA KITSEINRLA VTEVLSIAPN KIFSKSAQHY
1110 1120 1130 1140 1150
TTTEIDLNDI MQNIEPTYPH GLRVVYESLP FYKAEKIVNL ISGTKSITNI
1160 1170 1180 1190 1200
LEKTSAIDTT DINRATDMMR KNITLLIRIL PLDCNKDKRE LLSLENLSIT
1210 1220 1230 1240 1250
ELSKYVRERS WSLSNIVGVT SPSIMFTMDI KYTTSTIASG IIIEKYNVNS
1260 1270 1280 1290 1300
LTRGERGPTK PWVGSSTQEK KTMPVYNRQV LTKKQRDQID LLAKLDWVYA
1310 1320 1330 1340 1350
SIDNKDEFME ELSTGTLGLS YEKAKKLFPQ YLSVNYLHRL TVSSRPCEFP
1360 1370 1380 1390 1400
ASIPAYRTTN YHFDTSPINH VLTEKYGDED IDIVFQNCIS FGLSLMSVVE
1410 1420 1430 1440 1450
QFTNICPNRI ILIPKLNEIH LMKPPIFTGD VDIIKLKQVI QKQHMFLPDK
1460 1470 1480 1490 1500
ISLTQYVELF LSNKALKSGS NINSNLILVH KMSDYFHNAY ILSTNLAGHW
1510 1520 1530 1540 1550
ILIIQLMKDS KGIFEKDWGE GYITDHMFIN LNVFFNAYKT YLLCFHKGYG
1560 1570 1580 1590 1600
KAKLECDMNT SDLLCVLELI DSSYWKSMSK VFLEQKVIKY IVNQDTSLHR
1610 1620 1630 1640 1650
IKGCHSFKLW FLKRLNNAKF TVCPWVVNID YHPTHMKAIL SYIDLVRMGL
1660 1670 1680 1690 1700
INVDKLTIKN KNKFNDEFYT SNLFYISYNF SDNTHLLTKQ IRIANSELED
1710 1720 1730 1740 1750
NYNKLYHPTP ETLENISLIP VKSNNSNKPK FCISGNTESI MMSTFSNKMH
1760 1770 1780 1790 1800
IKSSTVTTRF NYSKQDLYNL FPNVVIDRII DHSGNTAKSN QLYITTSHQT
1810 1820 1830 1840 1850
SLVRNSASLY CMLPWHHVNR FNFVFSSTGC KISIEYILKD LKIKDPSCIA
1860 1870 1880 1890 1900
FIGEGAGNLL LRTVVELHPD IRYIYRSLKD CNDHSLPIEF LRLYNGHINI
1910 1920 1930 1940 1950
DYGENLTIPA TDATNNIHWS YLHIKFAEPI SIFVCDAELP VTANWSKIII
1960 1970 1980 1990 2000
EWSKHVRKCK YCSSVNRCIL IAKYHAQDDI DFKLDNITIL KTYVCLGSKL
2010 2020 2030 2040 2050
KGSEVYLVLT IGPANILPVF DVVQNAKLIF SRTKNFIMPK KTDKESIDAN
2060 2070 2080 2090 2100
IKSLIPFLCY PITKKGIKTS LSKLKSVVNG DILSYSIAGR NEVFSNKLIN
2110 2120 2130 2140 2150
HKHMNILKWL DHVLNFRSAE LNYNHLYMIE STYPYLSELL NSLTTNELKK
2160
LIKITGSVLY NLPNEQ
Length:2,166
Mass (Da):249,767
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2D8925C7935EFFD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti822R → K. 1
Natural varianti1662N → H. 1
Natural varianti1886L → I. 1
Natural varianti2030F → L. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF013254 Genomic RNA Translation: AAB82439.1
AF013255 Genomic RNA Translation: AAB82445.1

NCBI Reference Sequences

More...
RefSeqi
NP_056866.1, NC_001781.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1489827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1489827

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013254 Genomic RNA Translation: AAB82439.1
AF013255 Genomic RNA Translation: AAB82445.1
RefSeqiNP_056866.1, NC_001781.1

3D structure databases

SMRiO36635
ModBaseiSearch...

Proteomic databases

PRIDEiO36635

Genome annotation databases

GeneIDi1489827
KEGGivg:1489827

Family and domain databases

InterProiView protein in InterPro
IPR003006 Ig/MHC_CS
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
PfamiView protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit
TIGRFAMsiTIGR04198 paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS00290 IG_MHC, 1 hit
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_HRSVB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O36635
Secondary accession number(s): O36637
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 1, 1998
Last modified: September 18, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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