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Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
GB virus C
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei818For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
Active sitei838For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
Active sitei859For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteasePROSITE-ProRule annotation, Transferase
Biological processHost-virus interaction, Inhibition of host innate immune response by virusSAAS annotation, Viral attachment to host cellSAAS annotation, Viral immunoevasion, Viral RNA replicationSAAS annotation, Virus entry into host cell
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PolyproteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGB virus CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54290 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaePegivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000139650 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei548 – 575HelicalSequence analysisAdd BLAST28
Transmembranei595 – 620HelicalSequence analysisAdd BLAST26
Transmembranei632 – 651HelicalSequence analysisAdd BLAST20
Transmembranei677 – 701HelicalSequence analysisAdd BLAST25
Transmembranei750 – 772HelicalSequence analysisAdd BLAST23
Transmembranei1525 – 1548HelicalSequence analysisAdd BLAST24
Transmembranei1709 – 1736HelicalSequence analysisAdd BLAST28
Transmembranei1742 – 1764HelicalSequence analysisAdd BLAST23
Transmembranei1776 – 1800HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei894 – 895Cleavage; by protease NS2-3PROSITE-ProRule annotation2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O36452

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini769 – 894Peptidase C18InterPro annotationAdd BLAST126
Domaini894 – 1074Peptidase S29InterPro annotationAdd BLAST181
Domaini1081 – 1237Helicase ATP-bindingInterPro annotationAdd BLAST157
Domaini1241 – 1404Helicase C-terminalInterPro annotationAdd BLAST164
Domaini2487 – 2601RdRp catalyticInterPro annotationAdd BLAST115

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.25.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024347 GB_virus_envelope
IPR002518 HCV_NS2
IPR000745 HCV_NS4a
IPR001490 HCV_NS4b
IPR002868 HCV_NS5a
IPR013193 HCV_NS5a_1B_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR013192 NS5A_1a
IPR038170 NS5A_1a_sf
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12786 GBV-C_env, 1 hit
PF01538 HCV_NS2, 1 hit
PF01006 HCV_NS4a, 1 hit
PF01001 HCV_NS4b, 1 hit
PF01506 HCV_NS5a, 1 hit
PF08300 HCV_NS5a_1a, 1 hit
PF08301 HCV_NS5a_1b, 1 hit
PF02907 Peptidase_S29, 1 hit
PF00998 RdRP_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51693 HCV_NS2_PRO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O36452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLLLLLVV EAGAILAPAT HVCRASGQYF LTNCCALENI GFCLEGGCLV
60 70 80 90 100
PLGCTVCTDR CWPLYQAGLA VRPGKSAAQL VGELGSLYGP LSVSAYVAGI
110 120 130 140 150
LGLGEVYSGV LTVGVALTRR AYPVPNLTCS VECELKWESE FWRWTEQLAS
160 170 180 190 200
NYWILEYLWK VPFDFWRGVM SLTPLLVCVA ALLLLEQRIV MVFLLVTMAG
210 220 230 240 250
MSQGAPASVL GSRPFEAGLT WQSCSCEANG SRVPTGERVW DRGNVTLLCD
260 270 280 290 300
CPNGPWVWLP AVCQAIGWGD PITHWSHGQN QWPLSCPQFV YGAVSVTCVW
310 320 330 340 350
GSVSWFASTG GRDSKIDVWS LVPVGSASCT IAALGSSDRD TVVELSEWGI
360 370 380 390 400
PCATCILDRR PASCGTCVRD CWPETGSVRF PFHRCGAGPR LTKDLEAVPF
410 420 430 440 450
VNRTTPFTIR GPLGNQGKGN PVRSPLGFGS YTMTKIRDSL HLVKCPTPAI
460 470 480 490 500
EPPTGTFGFF PGTPPLNNCM LLGTEVSEVL GGAGLTGGFY EPLVRRCSEL
510 520 530 540 550
AGRRNPVCPG FAWLSSGRPD GFIHVQGHLQ EVGAGNFIPP PRWLLLDFVF
560 570 580 590 600
VLLYLVKLAE ARLVPLILLL LWWWVNQLAV LGLPTAHAAV AGEVFAGPAL
610 620 630 640 650
SWCLGLPFVS MILGLANLVL YFRWMGPQRL MFLVLWKLAR GAFPLALLMG
660 670 680 690 700
IPATRGRTSV LGAEFCFDVT FEVDTSVLGW VVASVVAWAI ALLSSMSAGG
710 720 730 740 750
WRHKAVIYRT WCKGYQALRQ RVVRSPLGEG RPTKPLTFAW CLASYIWPDA
760 770 780 790 800
VMLVVVGLVL LFGLFDALDW ALEELLVSRP SLRRLARVVE CCVMAGEKAT
810 820 830 840 850
TIRLVSKMCA RGAYLFDHMG SLSRAVKERL PEWDAALEPL SFTRTDCRII
860 870 880 890 900
RDAARTLSCG QCVMGLPVVA RRGDEVLIGV FQDVNHLPPG FVPTAPVVIR
910 920 930 940 950
RCGKGFLGVT KAALTGRDPD LHPGNVMVLG TATSRSMGTC LNGLLFTTFH
960 970 980 990 1000
GASSRTIATP VGALNPRWWS ASDDVTVYPL PDGANSLTPC TCQAESCWVI
1010 1020 1030 1040 1050
RSDGALCHGL SKGDKVELDV AMEVSDFRGS SGSPVLCDEG HAVGMLVSVL
1060 1070 1080 1090 1100
HSGGRVTAAR FIRPWTQVPT DAKTTTEPPP VPAKGVFKEA PLFMPTGAGK
1110 1120 1130 1140 1150
STRVPLEYGN MGHKVLILNP SVATVRAMGP YMERLAGRHP SIYCGHDTTA
1160 1170 1180 1190 1200
FTRITDSPLT YSTYGRFLAN PRQMLRGVSV VICDECHSHD STVLLGIGRV
1210 1220 1230 1240 1250
RELARGCGVQ LVLYATATPP GSPMVQHPSI IETKLDVGEI PFYGHGISLE
1260 1270 1280 1290 1300
RMRTGRHLVF CHSKAECERL AGQFSSRGVN AIAYYRGKDS SIIKDGDLVV
1310 1320 1330 1340 1350
CATDALSTGY TGNFDSVTDC GLVVEEVVEV TLDPTITISL RTVPASAELS
1360 1370 1380 1390 1400
MQRRSRTGRG RSGRYYYAGV GKAPAGVVRS GPVWSAVEAG MTWYGMEPDL
1410 1420 1430 1440 1450
TANLLRLYDD CPYTAAIAAD IGEAAVFFAG LAPLRMHPDV SWAKVRGVNW
1460 1470 1480 1490 1500
PLLVGVQRTM CRETLSPGPS DDPQWAGLKG PNPVPLLLRW GNDLPSKVAG
1510 1520 1530 1540 1550
HHIVDDLVRR LGVAEGYVRC DAGPILMVGL AIAGGMIYAS YTGSLVVVTD
1560 1570 1580 1590 1600
WDVKGGGNPL YRNGDQATPQ PVVQVPPVDH RPGGESAPSD AKTVTDAVAA
1610 1620 1630 1640 1650
IQVNCDWSVM TLSIGEVLAL AQAKTAEAYT ATAKWLAGCY TGTRAVPTVS
1660 1670 1680 1690 1700
IVDKLFAGGW AAVVGHCHSV IAAAVAAYGA SRSPPLAAAA SYLMGLGDGG
1710 1720 1730 1740 1750
NAQARLASAL LLGAAGTALG TPVVGLTMAG AFMGGASVSP SLVTVLLGAV
1760 1770 1780 1790 1800
GGWEGVVNAA SLVFDFMAGK LSTDDLWYAI PVLTSPGAGL AGIALGLVLY
1810 1820 1830 1840 1850
SANNSGTTTW LNRLLTTLPR SSCIPDSYFQ QADYCDKVSA MLRRLSLTRT
1860 1870 1880 1890 1900
VVALVNREPR VDEVQVGYVW DLWEWIMRQV RMVIARVRAL CPVVSLPLWH
1910 1920 1930 1940 1950
CGEGWSGEWL LDGHVESRCL CGCVITGDVF NGQLKDPVYS TKLCRHYWMG
1960 1970 1980 1990 2000
TVPVNMLGYG ETSLLLASDT PKVVPFGTSG WAEVVVTPTH VVIRRTSCYK
2010 2020 2030 2040 2050
LLRQQILSAA VAEPYYVDGI PVSWEADARA PAMVYGPGQS ATIDGERYTL
2060 2070 2080 2090 2100
PHQLRMRNVA PSEVPSEVSI EIGTETEDSE LTEADLPPAA AALQAIENAA
2110 2120 2130 2140 2150
RILEPHIDVI MEDCSTPSLC GSSREMPVWG EDVPRTPSPA LISVTESSSD
2160 2170 2180 2190 2200
EKTPSASSSQ EDTPSSDSFE VIQESDTAES EDSVFNVALS VPKALFPQSD
2210 2220 2230 2240 2250
ATRKLTVRMS CCVEKSVTRF FSLGLTVADV ASLCEMEIQN HTAYCDKVRT
2260 2270 2280 2290 2300
PLELQVGCLV GNELTFECDK CEARQETLAS FSYIWSGVPL TRATPAKPPV
2310 2320 2330 2340 2350
VRPVGSLLVA DTTKVYVTNP HNVGRRVDNV TFWRAPRVHD KFLVDSIERA
2360 2370 2380 2390 2400
RRAAQACLSM GYTYEEAIRT VRPHAAMGWG SKVSVKDLAT PAGKMSVHDR
2410 2420 2430 2440 2450
FQEIAEGTPV PFTLTVKKEV FFKDRKEEKA PRFIVFPPLN FRIAAKLILG
2460 2470 2480 2490 2500
DPARVPKAVL GGAYAFQYTP NQRVKEMLKL WESKKTPCAI CVDATCFDSS
2510 2520 2530 2540 2550
ITEEDVALET ELYALASDHP EWVRALGKYY ASGTMVTPEG VPVGERYCRS
2560 2570 2580 2590 2600
SGVLTTSASN CLTCYIKVKA ACDRVGLKNV SFLIAGDDCL IICERPMCDP
2610 2620 2630 2640 2650
SEALGRALAS YGYACEPSYH ASLDAAPFCS TWLAECNADG KRHFFLTTDF
2660 2670 2680 2690 2700
RRPLARMSSE YSDPMASAIG YILLYPWHPI TRWVIIPHVL TCAFRGGGTP
2710 2720 2730 2740 2750
SDPVWCQVHG NYYKFPLDKL PNIIVALHGP AALRVTADTT KTKMEAGKVL
2760 2770 2780 2790 2800
SDLKLPGLAV HRKKAGALRT RMLRSHDWAE LARGLLWHPG LRLPPPEIAG
2810 2820 2830 2840
IPGGFPLSPP YMGVVHQLDF TAQRSRWWWL GFLTLLIVAL FG
Length:2,842
Mass (Da):307,198
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBEF6AC6E47E603F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF006500 Genomic RNA Translation: AAB65834.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006500 Genomic RNA Translation: AAB65834.1

3D structure databases

ProteinModelPortaliO36452
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di2.20.25.210, 1 hit
InterProiView protein in InterPro
IPR024347 GB_virus_envelope
IPR002518 HCV_NS2
IPR000745 HCV_NS4a
IPR001490 HCV_NS4b
IPR002868 HCV_NS5a
IPR013193 HCV_NS5a_1B_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR013192 NS5A_1a
IPR038170 NS5A_1a_sf
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
PfamiView protein in Pfam
PF12786 GBV-C_env, 1 hit
PF01538 HCV_NS2, 1 hit
PF01006 HCV_NS4a, 1 hit
PF01001 HCV_NS4b, 1 hit
PF01506 HCV_NS5a, 1 hit
PF08300 HCV_NS5a_1a, 1 hit
PF08301 HCV_NS5a_1b, 1 hit
PF02907 Peptidase_S29, 1 hit
PF00998 RdRP_3, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51693 HCV_NS2_PRO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO36452_9FLAV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O36452
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: December 5, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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