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Protein

Uracil-DNA glycosylase

Gene

46

Organism
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Alternative name(s):
UNGUniRule annotation
Gene namesi
Name:46
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
Proteomesi
  • UP000000941 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004057111 – 252Uracil-DNA glycosylaseAdd BLAST252

Proteomic databases

PRIDEiO36395

Structurei

3D structure databases

ProteinModelPortaliO36395
SMRiO36395
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000E7

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

O36395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWLRKHMW PALPDHQHHP SYDILLAEPW VQFLDMTPFF RQKLYNTLSK
60 70 80 90 100
INEMRKSCII YPPQAEIMSW SYLCAPEDVK VVIIGQDPYH GGQANGQAFS
110 120 130 140 150
VNKGFPVPPS LQNIFKEVRS CYPDFVSPGH GCLEEWGRQG VLLLNTILTV
160 170 180 190 200
EAKKPGSHSD LGWTWFTNLI ISTLSNKLNN CVFMLWGSKA IAKSLMINKQ
210 220 230 240 250
RHLVLKAQHP SPLAAKNNYS SSQCKFLGCG HFLTANKYLT QHNKVPIDWT

LE
Length:252
Mass (Da):28,794
Last modified:January 1, 1998 - v1
Checksum:iC0FA6A62AD38918A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA Translation: AAC58092.1
PIRiT03140
RefSeqiNP_065544.1, NC_002531.1

Genome annotation databases

GeneIDi911736
KEGGivg:911736

Similar proteinsi

Entry informationi

Entry nameiUNG_ALHV1
AccessioniPrimary (citable) accession number: O36395
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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