UniProtKB - O36375 (MCP_ALHV1)
Protein
Major capsid protein
Gene
MCP
Organism
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Status
Functioni
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation
GO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: Major capsid proteinUniRule annotationShort name: MCPUniRule annotation |
Gene namesi | Name:MCPUniRule annotation Synonyms:25 |
Organismi | Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) |
Taxonomic identifieri | 654901 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Macavirus › |
Virus hosti | Connochaetes taurinus (Blue wildebeest) [TaxID: 9927] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
- T=16 icosahedral viral capsid Source: UniProtKB-UniRule
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=16 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000405715 | 1 – 1370 | Major capsid proteinAdd BLAST | 1370 |
Proteomic databases
PRIDEi | O36375 |
Interactioni
Subunit structurei
Homomultimer. Makes the hexons and eleven out of twelve pentons.
Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.
Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.
Interacts with capsid vertex component 2/CVC2.
Interacts with the small capsomere-interacting protein/SCP.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the herpesviridae major capsid protein family.UniRule annotation
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
i Sequence
Sequence statusi: Complete.
O36375-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVCRLENRP LPHAAVEANL LRQVKESAAE GLFKSFQLLV GKDVRENSVR
60 70 80 90 100
FEVLLGVYAN VIEFVKFLET GLAASCINTE FRDLKRMVDG KIQFKVSVPT
110 120 130 140 150
IAHSDGRRPN KQRQYIVMKC TSKHHISAEI ELAIADLENM HMEPETDLDM
160 170 180 190 200
LEYIGTVKTV TSALQFGIDA LERGLIDTVL SVKLRHAPPL FILQSLSDPT
210 220 230 240 250
LTERGLKKSI KSDLVSMFKD HLITHSFFIN KAEALATPRQ YILGMLSSII
260 270 280 290 300
NSVSKETVFK GTSTYTTSSG EPVAGVIETT DAILNKLLTL LGEYKTEVVG
310 320 330 340 350
PAAYASYVVR GENLVTAVSY GRAMRSFEQF KNKLVDDPVG QAGSLDKNAD
360 370 380 390 400
SDNEYSSLPQ TTIPVSVVKV GSQPVIVESI QKMYNEAQAP FPLNRRMQYT
410 420 430 440 450
YFFPLGLFIP RPKYTTSTSV KLEDDSCLSS EVWVVNKTNT PLCFNYQNAL
460 470 480 490 500
RTLCHPRVNS PSACLQELQR SNLADNALEA FRDGLRSRPM DNMNLFAHVR
510 520 530 540 550
RFYLKRTEVV LLPIAQKCNL STDDLLHPTN HKLLQLELHP LFDFVVERVA
560 570 580 590 600
AEEAAFRATH RTFSGNIPQP LAPNQFQDSR GKQFEAATSL QHAVDDATLE
610 620 630 640 650
VIRSTAFDPT YPFICYIVEA MIHGQPEKFT MNIPFISLCI NTYWDNSGNL
660 670 680 690 700
AFINSFFMVK NICTHMGGGL INRDAYALYR KILGEVVAIK HAIVRMCGAE
710 720 730 740 750
QLGNNELQGY VNGLLDRQLL PPFAYRDTFA QLDNRGARFV IGAKEHDNSQ
760 770 780 790 800
AFVHALPDFE NANQVAPAMY HTRNTFNWDT FEYITVSNGN NDADAADLEK
810 820 830 840 850
IYYYVMLPVC TNGHMCGMGA DFENIAIVLG YNIPVFDIPQ FNGDDTVLEH
860 870 880 890 900
LENGPLRDIL IASEVNPTAD MLRMMIVSYL NCPQMTQVVR VKTRRDHCQN
910 920 930 940 950
LGPEQGAIIE HTVMVNGFVC FGIPERMKQV AKNMFYPVPF HRFYCDPLVA
960 970 980 990 1000
GSWDNHIQNY VMNNFSQRSL EAFNAPPGIM ADYAEWHKAP MAKYITSCKA
1010 1020 1030 1040 1050
STASLSAFTV MHNKLSPIAF IVQAKHKIHP GFALTVLRTD EVLAENVMFS
1060 1070 1080 1090 1100
ARASTSVFVG RPTVSRREVR ADAVSFEVNH ELATIETGLS YSSVVTPAHV
1110 1120 1130 1140 1150
ASITTDMGIY CQNLFSIFSN EIYDHADVNN YVARKIGVED AVNRHNPRAL
1160 1170 1180 1190 1200
IAGVGQISHP PGLVHGQYAT CEVIPTPVTA DVAYFQKSNS PRGRASCVVS
1210 1220 1230 1240 1250
SDINNQERAE QFLYDHSLPD PAYEYRSTVN PWASQKGSLG DVLYGSRYRQ
1260 1270 1280 1290 1300
VSSPGIYSPS KPFFNKEEML KNNRSFYTLV NEYAQRLAGY AATSCTDLQY
1310 1320 1330 1340 1350
VVINGTDVFL EQPCLFLQEA FPTLSASHRV LLDEYMSFKN THAPVHMGHY
1360 1370
FIEEVAPVKR VFKIGNKVAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF005370 Genomic DNA Translation: AAC58072.1 |
PIRi | T03120 |
RefSeqi | NP_065524.1, NC_002531.1 |
Genome annotation databases
GeneIDi | 911741 |
KEGGi | vg:911741 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF005370 Genomic DNA Translation: AAC58072.1 |
PIRi | T03120 |
RefSeqi | NP_065524.1, NC_002531.1 |
3D structure databases
SMRi | O36375 |
ModBasei | Search... |
Proteomic databases
PRIDEi | O36375 |
Genome annotation databases
GeneIDi | 911741 |
KEGGi | vg:911741 |
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCP_ALHV1 | |
Accessioni | O36375Primary (citable) accession number: O36375 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families