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UniProtKB - O36028 (ATCZ_SCHPO)
Protein
Putative phospholipid-transporting ATPase C4F10.16c
Gene
SPAC4F10.16c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.
By similarityCatalytic activityi
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). EC:7.6.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 600 | 4-aspartylphosphate intermediateBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled intramembrane lipid transporter activity Source: PomBase
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- magnesium ion binding Source: InterPro
GO - Biological processi
- phospholipid translocation Source: PomBase
Keywordsi
Molecular function | Translocase |
Biological process | Lipid transport, Transport |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-6798695, Neutrophil degranulation R-SPO-936837, Ion transport by P-type ATPases |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPAC4F10.16c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC4F10.16c |
VEuPathDBi | FungiDB:SPAC4F10.16c |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
- phospholipid-translocating ATPase complex Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 154 | CytoplasmicSequence analysisAdd BLAST | 154 | |
Transmembranei | 155 – 172 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 173 – 177 | LumenalSequence analysis | 5 | |
Transmembranei | 178 – 197 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 198 – 482 | CytoplasmicSequence analysisAdd BLAST | 285 | |
Transmembranei | 483 – 503 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 504 – 531 | LumenalSequence analysisAdd BLAST | 28 | |
Transmembranei | 532 – 552 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 553 – 1091 | CytoplasmicSequence analysisAdd BLAST | 539 | |
Transmembranei | 1092 – 1112 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1113 – 1124 | LumenalSequence analysisAdd BLAST | 12 | |
Transmembranei | 1125 – 1145 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1146 – 1174 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 1175 – 1197 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 1198 – 1212 | LumenalSequence analysisAdd BLAST | 15 | |
Transmembranei | 1213 – 1233 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1234 – 1240 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 1241 – 1261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1262 – 1276 | LumenalSequence analysisAdd BLAST | 15 | |
Transmembranei | 1277 – 1297 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1298 – 1367 | CytoplasmicSequence analysisAdd BLAST | 70 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343137 | 1 – 1367 | Putative phospholipid-transporting ATPase C4F10.16cAdd BLAST | 1367 |
Proteomic databases
PaxDbi | O36028 |
PRIDEi | O36028 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 279941, 8 interactors |
STRINGi | 4896.SPAC4F10.16c.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 104 | DisorderedSequence analysisAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 38 – 53 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 54 – 76 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 77 – 101 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0206, Eukaryota |
HOGENOMi | CLU_000846_0_1_1 |
InParanoidi | O36028 |
OMAi | CETALDQ |
PhylomeDBi | O36028 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR032631, P-type_ATPase_N IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c IPR044492, P_typ_ATPase_HD_dom IPR026871, PLip_transp_ATPase |
PANTHERi | PTHR24092:SF91, PTHR24092:SF91, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit PF16209, PhoLip_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
O36028-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSLINFDAI SSLKSSLHGL SICAFNHLHH VPQHNGSLAH EGPTNQTDYS
60 70 80 90 100
SRHHESQFSQ EAHAEQRSRD DEEANSFEGS CNNSDQSWTS RVTSKKNEAG
110 120 130 140 150
TESGDASVRR IYVTSIPEEH RHLPSQWFPS NKIRTTKYTP VSFIPKNLWN
160 170 180 190 200
QFKNIANAFF LFVTLLQCIP LFCPEHLGLS FIPLSVILLT TAIKDGIEDY
210 220 230 240 250
RRCVLDKKFN NTLTWKLVGF NNANALGEHI GLWRKLKKFI SHTVADMSYC
260 270 280 290 300
LKNSGISSGL ATLTVDNISH RHSLESDSAF TLSSVSQDSL EIHEIGNSGP
310 320 330 340 350
SNSFSVIQEQ STGSSNAKFE RVCRKSLLVG DIVKVLADEA IPADLLILST
360 370 380 390 400
ENSNGVCYVE TKNLDGETNL KDKYALCSTK CCKSEYRCSA ASFWVECEQP
410 420 430 440 450
HADLYSLNGV VKAPGAVQSP SESTNGRKIH EEPFSISNVL LCGCTLRNSK
460 470 480 490 500
WVIGLVLYTG SETRIQKNRG LTPSKRSRIT RDLNWTIILN FLLLFAMCLF
510 520 530 540 550
SGVLRSIYSA QNNSARVFEL SKNSNTAPAH GIISIFTSLI LFQNLVPISL
560 570 580 590 600
YITMDIVRSI QSYFIFSDRE MYDEKLDCPC SPKSWNISDD LGQIEYIFSD
610 620 630 640 650
KTGTLTQNIM SFKKCSINGI RYGKSHNEDT CIKKRRNLNY NENLSCKVDL
660 670 680 690 700
DKKKMLETLS LSDSPNPESI TFISSKFVDH LQSNENYIQT EACFEFFKAL
710 720 730 740 750
ALCHSVVTDV QDETLIYNAQ SPDEEALVKV ARDFGFTLLN TKNRRYTIRI
760 770 780 790 800
RGENKNFRVL DIIPFTSTRK RMSVIIRDED GIIHLICKGA DTVIFPRLSS
810 820 830 840 850
GQNNIIEKTK KHLASFSSEG FRTLCIARRT IDKQDYLEWK VNFNEANSAI
860 870 880 890 900
HERNEKVSKV SEMIEQELEL LGGTAIEDKL QENVPETIAL LAIAGIKLWV
910 920 930 940 950
LTGDKVETAI NIGYSCNLLD PNMTIFRIDA NSFGALEEVE AFIRNTLCFN
960 970 980 990 1000
FGYMGTDEEF RFLLKDHSPP SPKHAIVIDG DALNFVLSEQ VSFLFLMLCK
1010 1020 1030 1040 1050
QCKTVLCCRV SPSQKAAVVA LVKKSLNVVT LAIGDGANDV SMIQEADVGV
1060 1070 1080 1090 1100
GIKGVEGQAA SMSADYAIGQ FSFLGRLLLV HGRWDYKRMS QMISFFFYKN
1110 1120 1130 1140 1150
VIWTFILFWY QFYNEFDGNY IFDYTYVMLF NLLFTSLPVI IAGCFDQDVD
1160 1170 1180 1190 1200
ASVSMKNPSL YQRGILGLEW NGKRFWSYML DGIYQSLVCF GVALFVFKFG
1210 1220 1230 1240 1250
DFVSWTGRNI ECIEDIGLFI SSPTIFVINI FILMNQERLN LISLITWMFS
1260 1270 1280 1290 1300
IGVFWIWTFI YSEVGPSYAF HKSASRTCQT FGFWCVTVLT IALCLLPRFS
1310 1320 1330 1340 1350
YICLQKLFYP RDIDLLRRRL CAKSDDETSS SSSFATDIEM CEQCNDPLSS
1360
KKNSGIVTSV SFDDSNK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11719.1 |
PIRi | T38820 |
RefSeqi | NP_594759.1, NM_001020186.2 |
Genome annotation databases
EnsemblFungii | SPAC4F10.16c.1; SPAC4F10.16c.1:pep; SPAC4F10.16c |
GeneIDi | 2543523 |
KEGGi | spo:SPAC4F10.16c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11719.1 |
PIRi | T38820 |
RefSeqi | NP_594759.1, NM_001020186.2 |
3D structure databases
AlphaFoldDBi | O36028 |
SMRi | O36028 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 279941, 8 interactors |
STRINGi | 4896.SPAC4F10.16c.1 |
Proteomic databases
PaxDbi | O36028 |
PRIDEi | O36028 |
Genome annotation databases
EnsemblFungii | SPAC4F10.16c.1; SPAC4F10.16c.1:pep; SPAC4F10.16c |
GeneIDi | 2543523 |
KEGGi | spo:SPAC4F10.16c |
Organism-specific databases
PomBasei | SPAC4F10.16c |
VEuPathDBi | FungiDB:SPAC4F10.16c |
Phylogenomic databases
eggNOGi | KOG0206, Eukaryota |
HOGENOMi | CLU_000846_0_1_1 |
InParanoidi | O36028 |
OMAi | CETALDQ |
PhylomeDBi | O36028 |
Enzyme and pathway databases
Reactomei | R-SPO-6798695, Neutrophil degranulation R-SPO-936837, Ion transport by P-type ATPases |
Miscellaneous databases
PROi | PR:O36028 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR032631, P-type_ATPase_N IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c IPR044492, P_typ_ATPase_HD_dom IPR026871, PLip_transp_ATPase |
PANTHERi | PTHR24092:SF91, PTHR24092:SF91, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit PF16209, PhoLip_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATCZ_SCHPO | |
Accessioni | O36028Primary (citable) accession number: O36028 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families