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Protein

Putative phospholipid-transporting ATPase C4F10.16c

Gene

SPAC4F10.16c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei6004-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phospholipid-transporting ATPase C4F10.16c (EC:3.6.3.1)
Gene namesi
ORF Names:SPAC4F10.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.16c
PomBaseiSPAC4F10.16c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 154CytoplasmicSequence analysisAdd BLAST154
Transmembranei155 – 172HelicalSequence analysisAdd BLAST18
Topological domaini173 – 177LumenalSequence analysis5
Transmembranei178 – 197HelicalSequence analysisAdd BLAST20
Topological domaini198 – 482CytoplasmicSequence analysisAdd BLAST285
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 531LumenalSequence analysisAdd BLAST28
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 1091CytoplasmicSequence analysisAdd BLAST539
Transmembranei1092 – 1112HelicalSequence analysisAdd BLAST21
Topological domaini1113 – 1124LumenalSequence analysisAdd BLAST12
Transmembranei1125 – 1145HelicalSequence analysisAdd BLAST21
Topological domaini1146 – 1174CytoplasmicSequence analysisAdd BLAST29
Transmembranei1175 – 1197HelicalSequence analysisAdd BLAST23
Topological domaini1198 – 1212LumenalSequence analysisAdd BLAST15
Transmembranei1213 – 1233HelicalSequence analysisAdd BLAST21
Topological domaini1234 – 1240CytoplasmicSequence analysis7
Transmembranei1241 – 1261HelicalSequence analysisAdd BLAST21
Topological domaini1262 – 1276LumenalSequence analysisAdd BLAST15
Transmembranei1277 – 1297HelicalSequence analysisAdd BLAST21
Topological domaini1298 – 1367CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003431371 – 1367Putative phospholipid-transporting ATPase C4F10.16cAdd BLAST1367

Proteomic databases

PaxDbiO36028
PRIDEiO36028

Interactioni

Protein-protein interaction databases

BioGridi279941, 8 interactors
STRINGi4896.SPAC4F10.16c.1

Structurei

3D structure databases

ProteinModelPortaliO36028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202528
InParanoidiO36028
KOiK01530
OrthoDBiEOG092C0BQ4
PhylomeDBiO36028

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
IPR026871 PLip_transp_ATPase
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF34 PTHR24092:SF34, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

O36028-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSLINFDAI SSLKSSLHGL SICAFNHLHH VPQHNGSLAH EGPTNQTDYS
60 70 80 90 100
SRHHESQFSQ EAHAEQRSRD DEEANSFEGS CNNSDQSWTS RVTSKKNEAG
110 120 130 140 150
TESGDASVRR IYVTSIPEEH RHLPSQWFPS NKIRTTKYTP VSFIPKNLWN
160 170 180 190 200
QFKNIANAFF LFVTLLQCIP LFCPEHLGLS FIPLSVILLT TAIKDGIEDY
210 220 230 240 250
RRCVLDKKFN NTLTWKLVGF NNANALGEHI GLWRKLKKFI SHTVADMSYC
260 270 280 290 300
LKNSGISSGL ATLTVDNISH RHSLESDSAF TLSSVSQDSL EIHEIGNSGP
310 320 330 340 350
SNSFSVIQEQ STGSSNAKFE RVCRKSLLVG DIVKVLADEA IPADLLILST
360 370 380 390 400
ENSNGVCYVE TKNLDGETNL KDKYALCSTK CCKSEYRCSA ASFWVECEQP
410 420 430 440 450
HADLYSLNGV VKAPGAVQSP SESTNGRKIH EEPFSISNVL LCGCTLRNSK
460 470 480 490 500
WVIGLVLYTG SETRIQKNRG LTPSKRSRIT RDLNWTIILN FLLLFAMCLF
510 520 530 540 550
SGVLRSIYSA QNNSARVFEL SKNSNTAPAH GIISIFTSLI LFQNLVPISL
560 570 580 590 600
YITMDIVRSI QSYFIFSDRE MYDEKLDCPC SPKSWNISDD LGQIEYIFSD
610 620 630 640 650
KTGTLTQNIM SFKKCSINGI RYGKSHNEDT CIKKRRNLNY NENLSCKVDL
660 670 680 690 700
DKKKMLETLS LSDSPNPESI TFISSKFVDH LQSNENYIQT EACFEFFKAL
710 720 730 740 750
ALCHSVVTDV QDETLIYNAQ SPDEEALVKV ARDFGFTLLN TKNRRYTIRI
760 770 780 790 800
RGENKNFRVL DIIPFTSTRK RMSVIIRDED GIIHLICKGA DTVIFPRLSS
810 820 830 840 850
GQNNIIEKTK KHLASFSSEG FRTLCIARRT IDKQDYLEWK VNFNEANSAI
860 870 880 890 900
HERNEKVSKV SEMIEQELEL LGGTAIEDKL QENVPETIAL LAIAGIKLWV
910 920 930 940 950
LTGDKVETAI NIGYSCNLLD PNMTIFRIDA NSFGALEEVE AFIRNTLCFN
960 970 980 990 1000
FGYMGTDEEF RFLLKDHSPP SPKHAIVIDG DALNFVLSEQ VSFLFLMLCK
1010 1020 1030 1040 1050
QCKTVLCCRV SPSQKAAVVA LVKKSLNVVT LAIGDGANDV SMIQEADVGV
1060 1070 1080 1090 1100
GIKGVEGQAA SMSADYAIGQ FSFLGRLLLV HGRWDYKRMS QMISFFFYKN
1110 1120 1130 1140 1150
VIWTFILFWY QFYNEFDGNY IFDYTYVMLF NLLFTSLPVI IAGCFDQDVD
1160 1170 1180 1190 1200
ASVSMKNPSL YQRGILGLEW NGKRFWSYML DGIYQSLVCF GVALFVFKFG
1210 1220 1230 1240 1250
DFVSWTGRNI ECIEDIGLFI SSPTIFVINI FILMNQERLN LISLITWMFS
1260 1270 1280 1290 1300
IGVFWIWTFI YSEVGPSYAF HKSASRTCQT FGFWCVTVLT IALCLLPRFS
1310 1320 1330 1340 1350
YICLQKLFYP RDIDLLRRRL CAKSDDETSS SSSFATDIEM CEQCNDPLSS
1360
KKNSGIVTSV SFDDSNK
Length:1,367
Mass (Da):154,282
Last modified:January 1, 1998 - v1
Checksum:i4DCFD8A7479465EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11719.1
PIRiT38820
RefSeqiNP_594759.1, NM_001020186.2

Genome annotation databases

EnsemblFungiiSPAC4F10.16c.1; SPAC4F10.16c.1:pep; SPAC4F10.16c
GeneIDi2543523
KEGGispo:SPAC4F10.16c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11719.1
PIRiT38820
RefSeqiNP_594759.1, NM_001020186.2

3D structure databases

ProteinModelPortaliO36028
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279941, 8 interactors
STRINGi4896.SPAC4F10.16c.1

Proteomic databases

PaxDbiO36028
PRIDEiO36028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4F10.16c.1; SPAC4F10.16c.1:pep; SPAC4F10.16c
GeneIDi2543523
KEGGispo:SPAC4F10.16c

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.16c
PomBaseiSPAC4F10.16c

Phylogenomic databases

HOGENOMiHOG000202528
InParanoidiO36028
KOiK01530
OrthoDBiEOG092C0BQ4
PhylomeDBiO36028

Enzyme and pathway databases

ReactomeiR-SPO-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:O36028

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
IPR026871 PLip_transp_ATPase
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF34 PTHR24092:SF34, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATCZ_SCHPO
AccessioniPrimary (citable) accession number: O36028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 1, 1998
Last modified: July 18, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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