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Entry version 108 (07 Apr 2021)
Sequence version 1 (01 Jan 1998)
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Protein

GYF domain-containing protein mpd2

Gene

mpd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in mRNA export from the nucleus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GYF domain-containing protein mpd2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mpd2
ORF Names:SPAC4F10.13c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC4F10.13c, mpd2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC4F10.13c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003394061 – 992GYF domain-containing protein mpd2Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei175Phosphoserine1 Publication1
Modified residuei318Phosphothreonine1 Publication1
Modified residuei320Phosphoserine1 Publication1
Modified residuei509Phosphoserine1 Publication1
Modified residuei604Phosphoserine1 Publication1
Modified residuei637Phosphoserine1 Publication1
Modified residuei775Phosphoserine1 Publication1
Modified residuei829Phosphoserine1 Publication1
Modified residuei838Phosphoserine1 Publication1
Modified residuei840Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O36025

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O36025

PRoteomics IDEntifications database

More...
PRIDEi
O36025

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O36025

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279865, 36 interactors

Protein interaction database and analysis system

More...
IntActi
O36025, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC4F10.13c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O36025

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini386 – 434GYFPROSITE-ProRule annotationAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMY2/mpd2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1862, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_292587_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O36025

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDWEFQV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O36025

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213, GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444, GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277, SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829, GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O36025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSEASVFSN MDWSQLAHSL HKKANNSSSS TTGAFPQLTS FTKPTATNGV
60 70 80 90 100
DSPTSSHIDP SVSAKLDSQR KLSLKSGNMW DSLNAPSELT SKNPTVSSTT
110 120 130 140 150
SSANPAIVSN GGSPFYKNPV VANNPSSTFD MSTNLFNSKN ANTSFTNAFS
160 170 180 190 200
NEGISPGFLR DCFPSSNSIT TGTASPKLGS PFNHINRPVL DRSPSSFSQS
210 220 230 240 250
RSAVSGNMNP GVGTLQQPQR AGSDTFPDLN TSSSNQPGGE PNVASANTHS
260 270 280 290 300
LEILSSSAYH PSGSSNGISA GLTQSVASPV GQVDNLADFS QSPLRRGPSR
310 320 330 340 350
FPTNSNVPVG NSMSIRDTDS PLNILVDKAK AKASIKENAS QPVAPSASQR
360 370 380 390 400
EHSAVNSPAA AMSPSTAMFS SEAFPQHLAS LIPPALLHWL YKDPQNNVQG
410 420 430 440 450
PFTGVDMHQW YRAGYFPLGL PIKRLEEEEY YSLAFFIRQV GNQLEPFLVP
460 470 480 490 500
LSPVTVQNAS WNAQGTDLPL SNYLPESSEQ NRGGNKHLEL YPSTAEVSNV
510 520 530 540 550
RNDESKANSL SEISYNQQSE CRSSELNVNE DSANQKEESA LGTSDNSDMY
560 570 580 590 600
EKENTPIHHN ESLNQLSKDL GSISLSEETK QEKPSKLKET VESKRLSTGV
610 620 630 640 650
QKQSPAASKE IPVTSGSQTT APKPSPWKSL PPKHLPSLDE TISREMSIAS
660 670 680 690 700
SEALPQVEKS NSDQPPVAIP STSKTGSPWA KVSDVSTSMA QEIQRMEKQN
710 720 730 740 750
ENLKSKVASN PVSQTSTNAK ASTPALASGS IWGSPSVINA WANKPAALKS
760 770 780 790 800
PLIKKNIQQA ELAQNKQQSS VTTASPRSNA LNANTPKAAA PSSNVTMKNV
810 820 830 840 850
TSILETSTFE GEDTWSVVGP GGKIVNQQSP SAQQTTRSPS KVSATLNAGN
860 870 880 890 900
SQASTSSKLQ QVVSMSGHSP DFLAWCKISL KGLNEGVNYE EFLDMLLSLP
910 920 930 940 950
AENNVETFEI ISDSIYANST IMDGRRFASE FTRRRIADLT GKDGQQSNNK
960 970 980 990
SQSELGNSSG AWSQVVRNKP KQGTEWNSAF KVVTSKKNKK RV
Length:992
Mass (Da):106,142
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4751B990B0C39345
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11716.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38817

NCBI Reference Sequences

More...
RefSeqi
NP_594756.1, NM_001020183.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC4F10.13c.1; SPAC4F10.13c.1:pep; SPAC4F10.13c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2543445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC4F10.13c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11716.1
PIRiT38817
RefSeqiNP_594756.1, NM_001020183.2

3D structure databases

SMRiO36025
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi279865, 36 interactors
IntActiO36025, 2 interactors
STRINGi4896.SPAC4F10.13c.1

PTM databases

iPTMnetiO36025

Proteomic databases

MaxQBiO36025
PaxDbiO36025
PRIDEiO36025

Genome annotation databases

EnsemblFungiiSPAC4F10.13c.1; SPAC4F10.13c.1:pep; SPAC4F10.13c
GeneIDi2543445
KEGGispo:SPAC4F10.13c

Organism-specific databases

PomBaseiSPAC4F10.13c, mpd2
VEuPathDBiFungiDB:SPAC4F10.13c

Phylogenomic databases

eggNOGiKOG1862, Eukaryota
HOGENOMiCLU_292587_0_0_1
InParanoidiO36025
OMAiDDWEFQV
PhylomeDBiO36025

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O36025

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
PfamiView protein in Pfam
PF02213, GYF, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SUPFAMiSSF55277, SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPD2_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O36025
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 1, 1998
Last modified: April 7, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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