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UniProtKB - O35988 (SDC4_MOUSE)
Protein
Syndecan-4
Gene
Sdc4
Organism
Mus musculus (Mouse)
Status
Functioni
Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
By similarityGO - Molecular functioni
- fibronectin binding Source: MGI
- identical protein binding Source: MGI
- protein kinase C binding Source: MGI
- thrombospondin receptor activity Source: MGI
GO - Biological processi
- cell migration Source: GO_Central
- inner ear receptor cell stereocilium organization Source: MGI
- negative regulation of T cell proliferation Source: MGI
- neural tube closure Source: MGI
- positive regulation of exosomal secretion Source: MGI
- positive regulation of extracellular exosome assembly Source: MGI
- positive regulation of focal adhesion assembly Source: MGI
- positive regulation of protein kinase activity Source: MGI
- positive regulation of stress fiber assembly Source: MGI
- regulation of fibroblast migration Source: UniProtKB
- ureteric bud development Source: Ensembl
- wound healing Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928, HS-GAG biosynthesis R-MMU-2024096, HS-GAG degradation R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-3000170, Syndecan interactions R-MMU-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syndecan-4Short name: SYND4 Alternative name(s): Ryudocan core protein |
Gene namesi | Name:Sdc4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349164, Sdc4 |
VEuPathDBi | HostDB:ENSMUSG00000017009 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Other locations
- Membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
Note: Shedding of the ectodomain produces a soluble form.1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi lumen Source: Reactome
Other locations
- cell surface Source: MGI
- costamere Source: MGI
- focal adhesion Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 145 | ExtracellularSequence analysisAdd BLAST | 122 | |
Transmembranei | 146 – 170 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 171 – 198 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000033512 | 24 – 198 | Syndecan-4Add BLAST | 175 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 44 | O-linked (Xyl...) (heparan sulfate) serineBy similarity | 1 | |
Glycosylationi | 62 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 64 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 |
Post-translational modificationi
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.1 Publication
Keywords - PTMi
Glycoprotein, Heparan sulfate, ProteoglycanProteomic databases
EPDi | O35988 |
jPOSTi | O35988 |
PaxDbi | O35988 |
PeptideAtlasi | O35988 |
PRIDEi | O35988 |
ProteomicsDBi | 255375 |
PTM databases
GlyGeni | O35988, 3 sites |
iPTMneti | O35988 |
PhosphoSitePlusi | O35988 |
Expressioni
Tissue specificityi
Ubiquitous. Highest levels in liver, kidney and lung.
Gene expression databases
Bgeei | ENSMUSG00000017009, Expressed in stria vascularis of cochlear duct and 325 other tissues |
ExpressionAtlasi | O35988, baseline and differential |
Genevisiblei | O35988, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with CDCP1 and SDCBP (By similarity).
Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain).
Interacts (via its cytoplasmic domain) with NUDT16L1.
By similarity2 PublicationsBinary interactionsi
O35988
With | #Exp. | IntAct |
---|---|---|
PCOLCE [Q15113] from Homo sapiens. | 2 | EBI-9986850,EBI-8869614 |
GO - Molecular functioni
- fibronectin binding Source: MGI
- identical protein binding Source: MGI
- protein kinase C binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203604, 5 interactors |
IntActi | O35988, 3 interactors |
MINTi | O35988 |
STRINGi | 10090.ENSMUSP00000017153 |
Miscellaneous databases
RNActi | O35988, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 76 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 94 – 130 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 66 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 102 – 122 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the syndecan proteoglycan family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1SZ, Eukaryota |
GeneTreei | ENSGT00940000160663 |
HOGENOMi | CLU_046599_3_0_1 |
InParanoidi | O35988 |
OMAi | GSWVPTE |
OrthoDBi | 1507361at2759 |
PhylomeDBi | O35988 |
TreeFami | TF320463 |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O35988-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPACLLAPL LLLLLGGFPL VPGESIRETE VIDPQDLLEG RYFSGALPDD
60 70 80 90 100
EDAGGSDDFE LSGSGDLDDT EEPRPFPEVI EPLVPLDNHI PENAQPGIRV
110 120 130 140 150
PSEPKELEEN EVIPKRAPSD VGDDMSNKVS MSSTAQGSNI FERTEVLAAL
160 170 180 190
IVGGVVGILF AVFLILLLVY RMKKKDEGSY DLGKKPIYKK APTNEFYA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89571 mRNA Translation: BAA22135.1 D89572 Genomic DNA Translation: BAA22136.1 BC005679 mRNA Translation: AAH05679.1 |
CCDSi | CCDS17036.1 |
PIRi | JC5613 |
RefSeqi | NP_035651.1, NM_011521.2 |
Genome annotation databases
Ensembli | ENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009 |
GeneIDi | 20971 |
KEGGi | mmu:20971 |
UCSCi | uc008nuq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89571 mRNA Translation: BAA22135.1 D89572 Genomic DNA Translation: BAA22136.1 BC005679 mRNA Translation: AAH05679.1 |
CCDSi | CCDS17036.1 |
PIRi | JC5613 |
RefSeqi | NP_035651.1, NM_011521.2 |
3D structure databases
AlphaFoldDBi | O35988 |
BMRBi | O35988 |
SMRi | O35988 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203604, 5 interactors |
IntActi | O35988, 3 interactors |
MINTi | O35988 |
STRINGi | 10090.ENSMUSP00000017153 |
Chemistry databases
ChEMBLi | CHEMBL2062355 |
PTM databases
GlyGeni | O35988, 3 sites |
iPTMneti | O35988 |
PhosphoSitePlusi | O35988 |
Proteomic databases
EPDi | O35988 |
jPOSTi | O35988 |
PaxDbi | O35988 |
PeptideAtlasi | O35988 |
PRIDEi | O35988 |
ProteomicsDBi | 255375 |
Protocols and materials databases
Antibodypediai | 969, 506 antibodies from 40 providers |
DNASUi | 20971 |
Genome annotation databases
Ensembli | ENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009 |
GeneIDi | 20971 |
KEGGi | mmu:20971 |
UCSCi | uc008nuq.1, mouse |
Organism-specific databases
CTDi | 6385 |
MGIi | MGI:1349164, Sdc4 |
VEuPathDBi | HostDB:ENSMUSG00000017009 |
Phylogenomic databases
eggNOGi | ENOG502S1SZ, Eukaryota |
GeneTreei | ENSGT00940000160663 |
HOGENOMi | CLU_046599_3_0_1 |
InParanoidi | O35988 |
OMAi | GSWVPTE |
OrthoDBi | 1507361at2759 |
PhylomeDBi | O35988 |
TreeFami | TF320463 |
Enzyme and pathway databases
Reactomei | R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928, HS-GAG biosynthesis R-MMU-2024096, HS-GAG degradation R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-3000170, Syndecan interactions R-MMU-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 20971, 2 hits in 73 CRISPR screens |
ChiTaRSi | Sdc4, mouse |
PROi | PR:O35988 |
RNActi | O35988, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017009, Expressed in stria vascularis of cochlear duct and 325 other tissues |
ExpressionAtlasi | O35988, baseline and differential |
Genevisiblei | O35988, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDC4_MOUSE | |
Accessioni | O35988Primary (citable) accession number: O35988 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families