Sdc4

Functionⁱ

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functionⁱ

fibronectin binding Source: MGI
identical protein binding Source: MGI
protein kinase C binding Source: MGI
thrombospondin receptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inner ear receptor cell stereocilium organization
Source: MGI
Inferred from genetic interactionⁱ
- 23760952
negative regulation of T cell proliferation Source: MGI
neural tube closure
Source: MGI
Inferred from genetic interactionⁱ
- 23760952
positive regulation of exosomal secretion Source: MGI
positive regulation of extracellular exosome assembly Source: MGI
positive regulation of focal adhesion assembly Source: MGI
positive regulation of protein kinase activity Source: MGI
positive regulation of stress fiber assembly Source: MGI
regulation of fibroblast migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25074804
ureteric bud development Source: Ensembl
wound healing
Source: MGI
Inferred from genetic interactionⁱ
- 23760952

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928 HS-GAG biosynthesis R-MMU-2024096 HS-GAG degradation R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-3000170 Syndecan interactions R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syndecan-4 Short name: SYND4 Alternative name(s): Ryudocan core protein
Gene namesⁱ	Name:Sdc4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1349164 Sdc4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 145	ExtracellularSequence analysisAdd BLAST	122
Transmembraneⁱ	146 – 170	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	171 – 198	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Membrane, Secreted

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2062355

ChEMBLⁱ

CHEMBL2062355

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000033512	24 – 198	Syndecan-4Add BLAST		175

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	44	O-linked (Xyl...) (heparan sulfate) serineBy similarity	1
Glycosylationⁱ	62	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Glycosylationⁱ	64	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1

Post-translational modificationⁱ

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.1 Publication

Keywords - PTMⁱ

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

EPDⁱ	O35988
PaxDbⁱ	O35988
PeptideAtlas More...PeptideAtlasⁱ	O35988
PRIDEⁱ	O35988

PTM databases

iPTMnetⁱ	O35988
PhosphoSitePlusⁱ	O35988

Miscellaneous databases

PMAP-CutDBⁱ	O35988

PMAP-CutDBⁱ

O35988

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highest levels in liver, kidney and lung.

Gene expression databases

Bgeeⁱ	ENSMUSG00000017009 Expressed in 302 organ(s), highest expression level in stria vascularis of cochlear duct
CleanExⁱ	MM_SDC4
ExpressionAtlasⁱ	O35988 baseline and differential
Genevisibleⁱ	O35988 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with CDCP1 and SDCBP (By similarity). Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PCOLCE	Q15113	2	EBI-9986850,EBI-8869614	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

PCOLCE

Q15113

2

EBI-9986850,EBI-8869614

From Homo sapiens.

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	O35988, 2 interactors
STRINGⁱ	10090.ENSMUSP00000017153

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35988
SMRⁱ	O35988
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXIG Eukaryota ENOG4111QSA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063116
HOGENOMⁱ	HOG000263414
HOVERGENⁱ	HBG004501
InParanoidⁱ	O35988
KEGG Orthology (KO) More...KOⁱ	K16338
OMAⁱ	QEPDDFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OOE
PhylomeDBⁱ	O35988
TreeFamⁱ	TF320463

Family and domain databases

InterProⁱ	View protein in InterPro IPR003585 Neurexin-like IPR001050 Syndecan IPR027789 Syndecan/Neurexin_dom IPR030479 Syndecan_CS
PANTHERⁱ	PTHR10915 PTHR10915, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit
PROSITEⁱ	View protein in PROSITE PS00964 SYNDECAN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O35988-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPACLLAPL LLLLLGGFPL VPGESIRETE VIDPQDLLEG RYFSGALPDD 
        60         70         80         90        100
EDAGGSDDFE LSGSGDLDDT EEPRPFPEVI EPLVPLDNHI PENAQPGIRV 
       110        120        130        140        150
PSEPKELEEN EVIPKRAPSD VGDDMSNKVS MSSTAQGSNI FERTEVLAAL 
       160        170        180        190 
IVGGVVGILF AVFLILLLVY RMKKKDEGSY DLGKKPIYKK APTNEFYA

Length:198

Mass (Da):21,482

Last modified:January 1, 1998 - v1

Checksum:ⁱ4246963EC6A25915

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D89571 mRNA Translation: BAA22135.1 D89572 Genomic DNA Translation: BAA22136.1 BC005679 mRNA Translation: AAH05679.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17036.1
PIRⁱ	JC5613
NCBI Reference Sequences More...RefSeqⁱ	NP_035651.1, NM_011521.2
UniGeneⁱ	Mm.3815

Genome annotation databases

Ensemblⁱ	ENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009
GeneIDⁱ	20971
KEGGⁱ	mmu:20971
UCSC genome browser More...UCSCⁱ	uc008nuq.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35988	Syndecan		MOUSE		198	UniRef100_O35988

Protein	Similar proteins		Species	Score	Length	Source
O35988	Syndecan-4	)	RAT		202	UniRef90_P34901
Syndecan		MOUSE		198
Syndecan (Fragment)		RATTA		193
Syndecan (Fragment)		lesser rice-field rat		193
Syndecan (Fragment)		RATEX		193
+41

Protein	Similar proteins		Species	Score	Length	Source
O35988	Syndecan-4	)	HUMAN		198	UniRef50_P31431
Syndecan-4		PONAB		198
Syndecan-4		CHICK		197
Syndecan-4	)	RAT		202
Syndecan		RHIRO		201
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D89571 mRNA Translation: BAA22135.1 D89572 Genomic DNA Translation: BAA22136.1 BC005679 mRNA Translation: AAH05679.1
CCDSⁱ	CCDS17036.1
PIRⁱ	JC5613
RefSeqⁱ	NP_035651.1, NM_011521.2
UniGeneⁱ	Mm.3815

3D structure databases

ProteinModelPortalⁱ	O35988
SMRⁱ	O35988
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O35988, 2 interactors
STRINGⁱ	10090.ENSMUSP00000017153

Chemistry databases

ChEMBLⁱ	CHEMBL2062355

ChEMBLⁱ

CHEMBL2062355

PTM databases

iPTMnetⁱ	O35988
PhosphoSitePlusⁱ	O35988

Proteomic databases

EPDⁱ	O35988
PaxDbⁱ	O35988
PeptideAtlasⁱ	O35988
PRIDEⁱ	O35988

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009
GeneIDⁱ	20971
KEGGⁱ	mmu:20971
UCSCⁱ	uc008nuq.1 mouse

Organism-specific databases

CTDⁱ	6385
MGIⁱ	MGI:1349164 Sdc4

Phylogenomic databases

eggNOGⁱ	ENOG410IXIG Eukaryota ENOG4111QSA LUCA
GeneTreeⁱ	ENSGT00530000063116
HOGENOMⁱ	HOG000263414
HOVERGENⁱ	HBG004501
InParanoidⁱ	O35988
KOⁱ	K16338
OMAⁱ	QEPDDFE
OrthoDBⁱ	EOG091G0OOE
PhylomeDBⁱ	O35988
TreeFamⁱ	TF320463

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928 HS-GAG biosynthesis R-MMU-2024096 HS-GAG degradation R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-3000170 Syndecan interactions R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	Sdc4 mouse
PMAP-CutDBⁱ	O35988
Protein Ontology More...PROⁱ	PR:O35988
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017009 Expressed in 302 organ(s), highest expression level in stria vascularis of cochlear duct
CleanExⁱ	MM_SDC4
ExpressionAtlasⁱ	O35988 baseline and differential
Genevisibleⁱ	O35988 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003585 Neurexin-like IPR001050 Syndecan IPR027789 Syndecan/Neurexin_dom IPR030479 Syndecan_CS
PANTHERⁱ	PTHR10915 PTHR10915, 1 hit
Pfamⁱ	View protein in Pfam PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit
PROSITEⁱ	View protein in PROSITE PS00964 SYNDECAN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SDC4_MOUSE
Accessionⁱ	O35988Primary (citable) accession number: O35988
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 1, 1998
	Last modified:	September 12, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O35988 (SDC4_MOUSE)

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Syndecan-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Golgi apparatus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ