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Protein

Pre-B-cell leukemia transcription factor 2

Gene

Pbx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi244 – 306Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

  • embryonic limb morphogenesis Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • proximal/distal pattern formation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 2
Alternative name(s):
Homeobox protein PBX2
Gene namesi
Name:Pbx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1341793 Pbx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492381 – 430Pre-B-cell leukemia transcription factor 2Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei159PhosphoserineCombined sources1
Modified residuei330PhosphoserineBy similarity1
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35984
PeptideAtlasiO35984
PRIDEiO35984

PTM databases

iPTMnetiO35984
PhosphoSitePlusiO35984

Expressioni

Gene expression databases

BgeeiENSMUSG00000034673 Expressed in 292 organ(s), highest expression level in hindlimb bud
CleanExiMM_PBX2
ExpressionAtlasiO35984 baseline and differential
GenevisibleiO35984 MM

Interactioni

Subunit structurei

Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202038, 8 interactors
IntActiO35984, 1 interactor
STRINGi10090.ENSMUSP00000040464

Structurei

3D structure databases

ProteinModelPortaliO35984
SMRiO35984
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 11Poly-Pro4
Compositional biasi137 – 145Poly-Ala9

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
HOGENOMiHOG000266972
HOVERGENiHBG000122
InParanoidiO35984
KOiK15609
OrthoDBiEOG091G10TD
PhylomeDBiO35984
TreeFamiTF314340

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O35984-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERLLGPPP PGGGRGGLGL VGAEPGGPGE PPGGGDPGGG SGGVPGGRGK
60 70 80 90 100
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL
110 120 130 140 150
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV
160 170 180 190 200
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT
210 220 230 240 250
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN
260 270 280 290 300
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI
310 320 330 340 350
RYKKNIGKFQ EEANIYAVKT AVSVAQGGHS RTSSPTPPSS AGSGGSFNLS
360 370 380 390 400
GSGDMFLGMP GLNGDSYPAS QVESLRHSMG PGSYGDNIGG GQIYSPREIR
410 420 430
ANGGWQEAVT PSSVTSPTEG PGSVHSDTSN
Length:430
Mass (Da):45,809
Last modified:January 1, 1998 - v1
Checksum:iCB6B71A6FE207E8D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UR63Q3UR63_MOUSE
Pre-B-cell leukemia transcription f...
Pbx2
348Annotation score:
V9GXB8V9GXB8_MOUSE
Pre B-cell leukemia transcription f...
Pbx2 mCG_5495
370Annotation score:
G3UXL9G3UXL9_MOUSE
Pre-B-cell leukemia transcription f...
Pbx2
147Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020198 mRNA Translation: AAB71193.1
AF030001 Genomic DNA Translation: AAB82006.1
BC010287 mRNA Translation: AAH10287.1
BC062147 mRNA Translation: AAH62147.1
CCDSiCCDS28648.1
PIRiT09061
RefSeqiNP_059491.1, NM_017463.2
UniGeneiMm.390957

Genome annotation databases

EnsembliENSMUST00000038149; ENSMUSP00000040464; ENSMUSG00000034673
GeneIDi18515
KEGGimmu:18515
UCSCiuc008ccv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020198 mRNA Translation: AAB71193.1
AF030001 Genomic DNA Translation: AAB82006.1
BC010287 mRNA Translation: AAH10287.1
BC062147 mRNA Translation: AAH62147.1
CCDSiCCDS28648.1
PIRiT09061
RefSeqiNP_059491.1, NM_017463.2
UniGeneiMm.390957

3D structure databases

ProteinModelPortaliO35984
SMRiO35984
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202038, 8 interactors
IntActiO35984, 1 interactor
STRINGi10090.ENSMUSP00000040464

PTM databases

iPTMnetiO35984
PhosphoSitePlusiO35984

Proteomic databases

PaxDbiO35984
PeptideAtlasiO35984
PRIDEiO35984

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038149; ENSMUSP00000040464; ENSMUSG00000034673
GeneIDi18515
KEGGimmu:18515
UCSCiuc008ccv.1 mouse

Organism-specific databases

CTDi5089
MGIiMGI:1341793 Pbx2

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
HOGENOMiHOG000266972
HOVERGENiHBG000122
InParanoidiO35984
KOiK15609
OrthoDBiEOG091G10TD
PhylomeDBiO35984
TreeFamiTF314340

Miscellaneous databases

ChiTaRSiPbx2 mouse
PROiPR:O35984
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034673 Expressed in 292 organ(s), highest expression level in hindlimb bud
CleanExiMM_PBX2
ExpressionAtlasiO35984 baseline and differential
GenevisibleiO35984 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPBX2_MOUSE
AccessioniPrimary (citable) accession number: O35984
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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