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Protein

Platelet glycoprotein Ib alpha chain

Gene

Gp1ba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.By similarity

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.By similarity
Binding sites for vWF and thrombin (the latter site with unknown function) are in the N-terminal part of the molecule.By similarity

GO - Biological processi

  • blood coagulation Source: MGI
  • cell adhesion Source: MGI
  • cell morphogenesis Source: MGI
  • fibrinolysis Source: MGI
  • hemostasis Source: MGI
  • platelet aggregation Source: MGI

Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein Ib alpha chain
Short name:
GP-Ib alpha
Short name:
GPIb-alpha
Short name:
GPIbA
Short name:
Glycoprotein Ibalpha
Alternative name(s):
CD_antigen: CD42b
Gene namesi
Name:Gp1ba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333744 Gp1ba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 612ExtracellularSequence analysisAdd BLAST596
Transmembranei613 – 633HelicalSequence analysisAdd BLAST21
Topological domaini634 – 734CytoplasmicSequence analysisAdd BLAST101

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000027174917 – 734Platelet glycoprotein Ib alpha chainAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 33By similarity
Disulfide bondi225 ↔ 264By similarity
Disulfide bondi227 ↔ 280By similarity
Modified residuei292SulfotyrosineBy similarity1
Disulfide bondi608Interchain (with C-147 in GP1BB)By similarity
Disulfide bondi609Interchain (with C-147 in GP1BB)By similarity
Modified residuei711PhosphoserineBy similarity1
Modified residuei714PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiO35930
PaxDbiO35930
PRIDEiO35930

PTM databases

iPTMnetiO35930
PhosphoSitePlusiO35930

Miscellaneous databases

PMAP-CutDBiO35930

Expressioni

Gene expression databases

BgeeiENSMUSG00000050675 Expressed in 53 organ(s), highest expression level in blood
CleanExiMM_GP1BA
ExpressionAtlasiO35930 baseline and differential
GenevisibleiO35930 MM

Interactioni

Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with FLNB. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-115 Glycoprotein Ib-IX-V complex
CPX-118 Glycoprotein Ib-IX-V-Filamin-A complex
STRINGi10090.ENSMUSP00000057563

Structurei

3D structure databases

ProteinModelPortaliO35930
SMRiO35930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 47LRRNTAdd BLAST31
Repeati48 – 69LRR 1Add BLAST22
Repeati72 – 93LRR 2Add BLAST22
Repeati94 – 115LRR 3Add BLAST22
Repeati117 – 140LRR 4Add BLAST24
Repeati141 – 162LRR 5Add BLAST22
Repeati165 – 188LRR 6Add BLAST24
Repeati189 – 210LRR 7Add BLAST22
Domaini221 – 282LRRCTAdd BLAST62

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148996
HOGENOMiHOG000234361
HOVERGENiHBG051790
InParanoidiO35930
KOiK06261
OMAiDCEILYF
OrthoDBiEOG091G08IS
PhylomeDBiO35930
TreeFamiTF351114

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLILLFLL PSPLHSQHTC SISKVTSLLE VNCENKKLTA LPADLPADTG
60 70 80 90 100
ILHLGENQLG TFSTASLVHF THLTYLYLDR CELTSLQTNG KLIKLENLDL
110 120 130 140 150
SHNNLKSLPS LGWALPALTT LDVSFNKLGS LSPGVLDGLS QLQELYLQNN
160 170 180 190 200
DLKSLPPGLL LPTTKLKKLN LANNKLRELP SGLLDGLEDL DTLYLQRNWL
210 220 230 240 250
RTIPKGFFGT LLLPFVFLHA NSWYCDCEIL YFRHWLQENA NNVYLWKQGV
260 270 280 290 300
DVKDTTPNVA SVRCANLDNA PVYSYPGKGC PTSSGDTDYD DYDDIPDVPA
310 320 330 340 350
TRTEVKFSTN TKVHTTHWSL LAAAPSTSQD SQMISLPPTH KPTKKQSTFI
360 370 380 390 400
HTQSPGFTTL PETMESNPTF YSLKLNTVLI PSPTTLEPTS TQATPEPNIQ
410 420 430 440 450
PMLTTSTLTT PEHSTTPVPT TTILTTPEHS TIPVPTTAIL TTPKPSTIPV
460 470 480 490 500
PTTATLTTLE PSTTPVPTTA TLTTPEPSTT LVPTTATLTT PEHSTTPVPT
510 520 530 540 550
TATLTTPEHS TTPVPTTATL TTPEPSTTLT NLVSTISPVL TTTLTTPEST
560 570 580 590 600
PIETILEQFF TTELTLLPTL ESTTTIIPEQ NSFLNLPEVA LVSSDTSESS
610 620 630 640 650
PFLNSDFCCF LPLGFYVLGL LWLLFASVVL ILLLTWTWHV TPHSLDMEQS
660 670 680 690 700
AALATSTHTT SLEVQRARQV TMPRAWLLFL QGSLPTFRSS LFLWVRPNGR
710 720 730
VGPLVAGRRP SALSQGRGQD LLGTVGIRYS GHSL
Length:734
Mass (Da):80,055
Last modified:January 9, 2007 - v2
Checksum:iFA42553EC2ED4D0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti532L → V in AAC53320 (PubMed:9410473).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91967 Genomic DNA Translation: AAC53320.1
AL596117 Genomic DNA Translation: CAI25162.1
CCDSiCCDS24957.1
RefSeqiNP_034456.2, NM_010326.2
XP_006532295.1, XM_006532232.3
UniGeneiMm.377085

Genome annotation databases

EnsembliENSMUST00000055184; ENSMUSP00000057563; ENSMUSG00000050675
ENSMUST00000108551; ENSMUSP00000104191; ENSMUSG00000050675
GeneIDi14723
KEGGimmu:14723
UCSCiuc007jvq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91967 Genomic DNA Translation: AAC53320.1
AL596117 Genomic DNA Translation: CAI25162.1
CCDSiCCDS24957.1
RefSeqiNP_034456.2, NM_010326.2
XP_006532295.1, XM_006532232.3
UniGeneiMm.377085

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K15model-A52-216[»]
ProteinModelPortaliO35930
SMRiO35930
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-115 Glycoprotein Ib-IX-V complex
CPX-118 Glycoprotein Ib-IX-V-Filamin-A complex
STRINGi10090.ENSMUSP00000057563

PTM databases

iPTMnetiO35930
PhosphoSitePlusiO35930

Proteomic databases

MaxQBiO35930
PaxDbiO35930
PRIDEiO35930

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055184; ENSMUSP00000057563; ENSMUSG00000050675
ENSMUST00000108551; ENSMUSP00000104191; ENSMUSG00000050675
GeneIDi14723
KEGGimmu:14723
UCSCiuc007jvq.1 mouse

Organism-specific databases

CTDi2811
MGIiMGI:1333744 Gp1ba

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148996
HOGENOMiHOG000234361
HOVERGENiHBG051790
InParanoidiO35930
KOiK06261
OMAiDCEILYF
OrthoDBiEOG091G08IS
PhylomeDBiO35930
TreeFamiTF351114

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)

Miscellaneous databases

PMAP-CutDBiO35930
PROiPR:O35930
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050675 Expressed in 53 organ(s), highest expression level in blood
CleanExiMM_GP1BA
ExpressionAtlasiO35930 baseline and differential
GenevisibleiO35930 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGP1BA_MOUSE
AccessioniPrimary (citable) accession number: O35930
Secondary accession number(s): Q5SX47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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