UniProtKB - O35927 (CTND2_MOUSE)
Catenin delta-2
Ctnnd2
Functioni
GO - Molecular functioni
- beta-catenin binding Source: MGI
- cadherin binding Source: GO_Central
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- cell-cell junction assembly Source: GO_Central
- dendritic spine morphogenesis Source: MGI
- learning Source: MGI
- morphogenesis of a branching structure Source: MGI
- regulation of canonical Wnt signaling pathway Source: MGI
- regulation of synaptic plasticity Source: MGI
- synapse organization Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Catenin delta-2Alternative name(s): Neural plakophilin-related ARM-repeat protein Short name: NPRAP Neurojungin |
Gene namesi | Name:Ctnnd2 Synonyms:Catnd2, Nprap |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1195966, Ctnnd2 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- adherens junction 1 Publication
- dendrite By similarity
- Perikaryon By similarity
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- cell-cell junction Source: GO_Central
- cytoplasm Source: GO_Central
- dendrite Source: UniProtKB-SubCell
- neuron projection Source: MGI
- perikaryon Source: UniProtKB
- postsynaptic density Source: MGI
Keywords - Cellular componenti
Cell junction, Cell projection, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064300 | 1 – 1247 | Catenin delta-2Add BLAST | 1247 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 209 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 261 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 264 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Modified residuei | 279 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 293 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 324 | PhosphoserineCombined sources | 1 | |
Modified residuei | 357 | PhosphoserineCombined sources | 1 | |
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Modified residuei | 458 | PhosphoserineCombined sources | 1 | |
Modified residuei | 511 | PhosphoserineCombined sources | 1 | |
Modified residuei | 513 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1087 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1098 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
MaxQBi | O35927 |
PaxDbi | O35927 |
PRIDEi | O35927 |
PTM databases
iPTMneti | O35927 |
PhosphoSitePlusi | O35927 |
SwissPalmi | O35927 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Interactioni
Subunit structurei
Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1.
Interacts with PDZD2 (By similarity).
Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (By similarity).
Interacts with ZBTB33.
Interacts with ARHGEF28 (PubMed:17993462).
Interacts with CDK5 (By similarity).
Interacts with CTNNB1 (By similarity).
Interacts with GSK3A and GSK3B (PubMed:20623542) (PubMed:19706605).
Interacts with DNM2 (By similarity).
Interacts with CCDC85B (By similarity).
By similarity5 PublicationsGO - Molecular functioni
- beta-catenin binding Source: MGI
- cadherin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 201832, 13 interactors |
IntActi | O35927, 9 interactors |
MINTi | O35927 |
STRINGi | 10090.ENSMUSP00000080427 |
Miscellaneous databases
RNActi | O35927, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 391 – 433 | ARM 1Add BLAST | 43 | |
Repeati | 537 – 576 | ARM 2Add BLAST | 40 | |
Repeati | 579 – 618 | ARM 3Add BLAST | 40 | |
Repeati | 623 – 663 | ARM 4Add BLAST | 41 | |
Repeati | 679 – 721 | ARM 5Add BLAST | 43 | |
Repeati | 725 – 770 | ARM 6Add BLAST | 46 | |
Repeati | 832 – 872 | ARM 7Add BLAST | 41 | |
Repeati | 904 – 943 | ARM 8Add BLAST | 40 | |
Repeati | 997 – 1040 | ARM 9Add BLAST | 44 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 49 – 84 | Sequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 218 – 225 | Poly-Pro | 8 | |
Compositional biasi | 245 – 248 | Poly-Ala | 4 | |
Compositional biasi | 478 – 481 | Poly-Ala | 4 | |
Compositional biasi | 808 – 814 | Poly-Lys | 7 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1048, Eukaryota |
InParanoidi | O35927 |
OrthoDBi | 233858at2759 |
PhylomeDBi | O35927 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
SMARTi | View protein in SMART SM00185, ARM, 8 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA
60 70 80 90 100
ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAGE
110 120 130 140 150
QFHWQTQDGQ KDIEDELTTG LELVDSCIRS LQESGILDPQ DYSTSERPSL
160 170 180 190 200
LSQSALQLNS KPEGSFQYPA SYHSNQTLAL GDTAPSQLPA RSTQARAAGQ
210 220 230 240 250
SFSQGTTGRA GHLAGSEPAP PPPPPREPFA PSLGSAFHLP DAPPAAAALY
260 270 280 290 300
YSSSTLPAPP RGGSPLTTTQ GGSPTKLQRG GSAPEGAAYA APRGSSPKQS
310 320 330 340 350
PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS SPIHQLSSTI
360 370 380 390 400
GTYATLSPTK RLVHASEQYS KHSQELYATA TLQRPGSLAA GSRASYSSQH
410 420 430 440 450
GHLAPELRAL QSPEHHIDPI YEDRVYQKPP MRSLSQSQGD PLPPAHTGTF
460 470 480 490 500
RTSTAPSSPG VDSVPLQRTG SQHGPQNAAA ATFQRASYAA GPASNYADPY
510 520 530 540 550
RQLQYCASVD SPYSKSGPAL PPEGTLARSP SIDSIQKDPR EFGWRDPELP
560 570 580 590 600
EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG IQLLVDLLDH
610 620 630 640 650
RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR LLRKTTDLEI
660 670 680 690 700
RELVTGVLWN LSSCDALKMP IIQDALAVLT NAVIIPHSGW ENSPLQDDRK
710 720 730 740 750
IQLHSSQVLR NATGCLRNVS SAGEEARRRM RECDGLTDAL LYVIQSALGS
760 770 780 790 800
SEIDSKTVEN CVCILRNLSY RLAAETSQGQ HMGTDELDGL LCGETNGKDT
810 820 830 840 850
ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH PSIVKPYLTL
860 870 880 890 900
LSECSNPDTL EGAAGALQNL AAGSWKGWAE DVAGMAYALR SLPEGAPCLP
910 920 930 940 950
QWSVYIRAAV RKEKGLPILV ELLRIDNDRV VCAVATALRN MALDVRNKEL
960 970 980 990 1000
IGKYAMRDLV HRLPGGNNSN NSGSKAMSDD TVTAVCCTLH EVITKNMENA
1010 1020 1030 1040 1050
KALRDAGGIE KLVGISKSKG DKHSPKVVKA ASQVLNSMWQ YRDLRSLYKK
1060 1070 1080 1090 1100
DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS ISPVRVSPNN RSASAPASPR
1110 1120 1130 1140 1150
EMISLKERKT DYESAGNNAT YHGTKGEHTS RKDTMTAQNT GVSTLYRNSY
1160 1170 1180 1190 1200
GAPAEDIKQN QVSTQPVPQE PSRKDYETYQ PFPNSTRNYD ESFFEDQVHH
1210 1220 1230 1240
RPPASEYTMH LGLKSTGNYV DFYSAARPYS ELNYETSHYP ASPDSWV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QKH8 | E9QKH8_MOUSE | Catenin delta-2 | Ctnnd2 | 1,246 | Annotation score: | ||
B7ZNF6 | B7ZNF6_MOUSE | Catenin delta-2 | Ctnnd2 | 1,221 | Annotation score: | ||
A0A2I3BQV7 | A0A2I3BQV7_MOUSE | Catenin delta-2 | Ctnnd2 | 103 | Annotation score: | ||
A0A2I3BQV6 | A0A2I3BQV6_MOUSE | Catenin delta-2 | Ctnnd2 | 145 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006747 | 878 – 902 | Missing in isoform 2. CuratedAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90331 mRNA Translation: AAB82409.1 BC138260 mRNA Translation: AAI38261.1 BC138261 mRNA Translation: AAI38262.1 |
PIRi | T42209 |
RefSeqi | NP_032755.2, NM_008729.2 |
Genome annotation databases
GeneIDi | 18163 |
KEGGi | mmu:18163 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90331 mRNA Translation: AAB82409.1 BC138260 mRNA Translation: AAI38261.1 BC138261 mRNA Translation: AAI38262.1 |
PIRi | T42209 |
RefSeqi | NP_032755.2, NM_008729.2 |
3D structure databases
SMRi | O35927 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201832, 13 interactors |
IntActi | O35927, 9 interactors |
MINTi | O35927 |
STRINGi | 10090.ENSMUSP00000080427 |
PTM databases
iPTMneti | O35927 |
PhosphoSitePlusi | O35927 |
SwissPalmi | O35927 |
Proteomic databases
MaxQBi | O35927 |
PaxDbi | O35927 |
PRIDEi | O35927 |
Genome annotation databases
GeneIDi | 18163 |
KEGGi | mmu:18163 |
Organism-specific databases
CTDi | 1501 |
MGIi | MGI:1195966, Ctnnd2 |
Phylogenomic databases
eggNOGi | KOG1048, Eukaryota |
InParanoidi | O35927 |
OrthoDBi | 233858at2759 |
PhylomeDBi | O35927 |
Miscellaneous databases
BioGRID-ORCSi | 18163, 4 hits in 17 CRISPR screens |
ChiTaRSi | Ctnnd2, mouse |
PROi | PR:O35927 |
RNActi | O35927, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
SMARTi | View protein in SMART SM00185, ARM, 8 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTND2_MOUSE | |
Accessioni | O35927Primary (citable) accession number: O35927 Secondary accession number(s): B2RR80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families