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Protein

Cyclin-dependent kinase 5 activator 2

Gene

Cdk5r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of CDK5/TPKII.

GO - Molecular functioni

  • actin binding Source: ARUK-UCL
  • cyclin-dependent protein kinase 5 activator activity Source: ARUK-UCL
  • cytoskeletal protein binding Source: MGI
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 activator 2
Short name:
CDK5 activator 2
Alternative name(s):
Cyclin-dependent kinase 5 regulatory subunit 2
p39
p39I
Gene namesi
Name:Cdk5r2
Synonyms:Nck5ai
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1330828 Cdk5r2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004803? – 369Cyclin-dependent kinase 5 activator 2
Initiator methionineiRemoved
PropeptideiPRO_00000048022 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei84PhosphothreonineCombined sources1

Post-translational modificationi

Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39) (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiO35926
PaxDbiO35926
PeptideAtlasiO35926
PRIDEiO35926

PTM databases

iPTMnetiO35926
PhosphoSitePlusiO35926

Expressioni

Gene expression databases

BgeeiENSMUSG00000090071 Expressed in 79 organ(s), highest expression level in supraoptic nucleus
GenevisibleiO35926 MM

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit and a regulatory subunit.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3145 Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant
CORUMiO35926
MINTiO35926
STRINGi10090.ENSMUSP00000125322

Structurei

3D structure databases

ProteinModelPortaliO35926
SMRiO35926
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 78Poly-Lys4
Compositional biasi155 – 163Poly-Pro9
Compositional biasi348 – 351Poly-Ser4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3932 Eukaryota
ENOG410YFUI LUCA
GeneTreeiENSGT00390000008812
HOGENOMiHOG000063677
HOVERGENiHBG050853
InParanoidiO35926
KOiK19929
OMAiKEVFWER
OrthoDBiEOG091G0OB3
TreeFamiTF101036

Family and domain databases

InterProiView protein in InterPro
IPR004944 CDK5_activator
IPR036915 Cyclin-like_sf
PfamiView protein in Pfam
PF03261 CDK5_activator, 1 hit
PIRSFiPIRSF009324 Cdk5_activator, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35926-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPAGKGGKG
60 70 80 90 100
ESRLKRPSVL ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN
110 120 130 140 150
RENLLRKGRD GPDGGGTAKP LAVPVPTVPT TAATCEPPSG GSAAAPPPGS
160 170 180 190 200
GGGKPPPPPP PAPQAAPPAP GGSPRRVIVQ ASTGELLRCL GDFVCRRCYR
210 220 230 240 250
LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY LLCRESLRGD
260 270 280 290 300
ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
310 320 330 340 350
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASTGGPPS GSSASTTSSS
360
SARDSCATGA KHWTMNLDR
Length:369
Mass (Da):38,924
Last modified:July 27, 2011 - v2
Checksum:iD426300E88441D99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91G → V in AAB69709 (Ref. 2) Curated1
Sequence conflicti172G → S in AAC53595 (PubMed:9655938).Curated1
Sequence conflicti191G → R in AAC53595 (PubMed:9655938).Curated1
Sequence conflicti197R → S in AAC53595 (PubMed:9655938).Curated1
Sequence conflicti220L → W in AAB69709 (Ref. 2) Curated1
Sequence conflicti248R → S in AAC53595 (PubMed:9655938).Curated1
Sequence conflicti253A → G in AAB69709 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90267 Genomic DNA Translation: AAC53595.1
AF016393 Genomic DNA Translation: AAB69709.1
AF071086 Genomic DNA Translation: AAF14854.1
CH466548 Genomic DNA Translation: EDL00353.1
CCDSiCCDS48290.1
RefSeqiNP_034002.2, NM_009872.3
UniGeneiMm.153833

Genome annotation databases

EnsembliENSMUST00000160379; ENSMUSP00000125322; ENSMUSG00000090071
GeneIDi12570
KEGGimmu:12570
UCSCiuc007bng.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCD5R2_MOUSE
AccessioniPrimary (citable) accession number: O35926
Secondary accession number(s): O35277, Q9QYD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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