Zinc finger protein basonuclin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW

GO - Biological processⁱ

• cell differentiation Source: UniProtKB-KW
• chromosome organization Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16624857
• positive regulation of epithelial cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 17971852
• regulation of transcription by RNA polymerase I Source: MGIInferred from mutant phenotypeⁱ
  • 16624857
• regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • 16624857
• spermatogenesis Source: UniProtKB-KW
• transcription, DNA-templated Source: UniProtKB-KW
• wound healing Source: MGIInferred from mutant phenotypeⁱ
  • 17971852

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MAEAIGCTLN CSCQCFKPGK INHRQCEQCR HGWVAHALSK LRIPPVYPTS 
        60         70         80         90        100
QVEIVQSNVV FDISSLMLYG TQAIPVRLKI LLDRLFSVLK QDEVLQILHA 
       110        120        130        140        150
LDWTLQDYIR GYVLQDASGK VLDHWSIMTS EEEVATLQQF LRFGETKSIV 
       160        170        180        190        200
ELMAIQEKEE QSVIVPPTTA NVDIRAFIES CGHRSASLPT PVDKGSPGGM 
       210        220        230        240        250
HPFENLISNM TFMLPFQFFN PLPPALIGSL PEQYMLEQGQ DQSQEPKQEL 
       260        270        280        290        300
HGPFSDSSFL TSTPFQVEKE QCLNCPETVP QKEDSAHLSD SSSYSIASKL 
       310        320        330        340        350
ERTQLSPEAK VKPERNSLSA KKGRVFCTAC EKTFYDKGTL KIHYNAVHLK 
       360        370        380        390        400
IKHKCTIEGC NMVFSSLRSR NRHSANPNPR LHMPMNRNNR DKDLRNSLNL 
       410        420        430        440        450
ASSETYKRPG FTVVSPDCGP LPGYTGSVED SKGQPAFSSI GQNGVLFPNL 
       460        470        480        490        500
KTVQPVLPFY RSPATPAELA NTPGMLPSLP LLSSSIPEQL VSTDMPFDAL 
       510        520        530        540        550
PKKKSRKSSM PIKIEKEAVE IAEEKRHSLS SDDEVPLQVV SEDEPEDSSP 
       560        570        580        590        600
RSDRVPEEQH TQLSLEEPLP QGERACHLES VIESHGALSR TLEQTTLTER 
       610        620        630        640        650
EAEQKVALSS VMPREVEDGG HERHFTAGLV PQIPFPDYME LQQRLLAGGL 
       660        670        680        690        700
FGALSNRGMA FPFLEESKEL EHLGEHALVR QKEEARFQCD ICKKTFKNAC 
       710        720        730        740        750
SMKTHEKNTH ARETHACTVE GCGAAFPSRR SRDRHSSNLS LHQKVLNEEA 
       760        770        780        790        800
LETSEDHFRA AYLLQDVAKE AYQDVAFTPQ ASQTSVIFKG TSGMGSLVYP 
       810        820        830        840        850
ISQVHSASLE SYNSGPPSEG TILDLSTTSS MKSESSSHSS WDSDGVSEEG 
       860        870        880        890        900
TALMEDSDGN CEGQSLVSGE DEYPLCVLME KADQSLASLP SGLPITCHLC 
       910        920        930        940        950
QKIYSNKGTF RAHYKTVHLR QLHKCKVPGC NTMFSSVRSR NRHSQNPNLH 
       960 
KSLASSPSHL Q                                           

Experimental Info

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ