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Protein

Epithelial membrane protein 3

Gene

Emp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Alternative name(s):
Hematopoietic neural membrane protein 1
Short name:
HNMP-1
Protein YMP
Gene namesi
Name:Emp3
Synonyms:Ymp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1098729 Emp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646611 – 163Epithelial membrane protein 3Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35912
PRIDEiO35912
TopDownProteomicsiO35912

PTM databases

iPTMnetiO35912
PhosphoSitePlusiO35912

Expressioni

Gene expression databases

BgeeiENSMUSG00000040212 Expressed in 227 organ(s), highest expression level in adrenal gland
CleanExiMM_EMP3
ExpressionAtlasiO35912 baseline and differential
GenevisibleiO35912 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037289

Structurei

3D structure databases

ProteinModelPortaliO35912
SMRiO35912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40 Eukaryota
ENOG4111MF9 LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiO35912
OMAiMEKSWWV
OrthoDBiEOG091G0RF4
TreeFamiTF330414

Family and domain databases

InterProiView protein in InterPro
IPR003934 EMP_3
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF8 PTHR10671:SF8, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01456 EPMEMPROT3
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLLLVVSA LHILILVLLF VATLDKSWWT LPDKESLNLW YDCTWNTTTQ
60 70 80 90 100
TWACSNVSEN GWLKAVQALM VLSLILCCLS FILFMFQLYT MRRGGLFYAT
110 120 130 140 150
GLCQLCTSAA VFSGALIYAI HTEEILAKHP SGGSFGYCFA LAWVAFPLAL
160
VSGTVYIHLR KRE
Length:163
Mass (Da):18,253
Last modified:October 3, 2012 - v2
Checksum:i91620FD4C6AEB70C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSZ1A0A1B0GSZ1_MOUSE
Epithelial membrane protein 3
Emp3
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96L → I in AAC33407 (PubMed:9615230).Curated1
Sequence conflicti106C → W in AAC33407 (PubMed:9615230).Curated1
Sequence conflicti129H → Q in AAC33407 (PubMed:9615230).Curated1
Sequence conflicti154 – 155TV → IMY in AAC33407 (PubMed:9615230).Curated2
Sequence conflicti154T → I in AAC53324 (PubMed:9204931).Curated1
Sequence conflicti154T → I in AAH01999 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87948 mRNA Translation: AAC53324.1
AF011750 mRNA Translation: AAC33407.1
AK146939 mRNA Translation: BAE27548.1
AC149053 Genomic DNA No translation available.
BC001999 mRNA Translation: AAH01999.1
CCDSiCCDS21270.1
RefSeqiNP_001139818.1, NM_001146346.1
NP_034259.2, NM_010129.2
UniGeneiMm.20829

Genome annotation databases

EnsembliENSMUST00000038876; ENSMUSP00000037289; ENSMUSG00000040212
ENSMUST00000164119; ENSMUSP00000132519; ENSMUSG00000040212
ENSMUST00000210297; ENSMUSP00000147800; ENSMUSG00000040212
GeneIDi13732
KEGGimmu:13732
UCSCiuc009gxv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87948 mRNA Translation: AAC53324.1
AF011750 mRNA Translation: AAC33407.1
AK146939 mRNA Translation: BAE27548.1
AC149053 Genomic DNA No translation available.
BC001999 mRNA Translation: AAH01999.1
CCDSiCCDS21270.1
RefSeqiNP_001139818.1, NM_001146346.1
NP_034259.2, NM_010129.2
UniGeneiMm.20829

3D structure databases

ProteinModelPortaliO35912
SMRiO35912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037289

PTM databases

iPTMnetiO35912
PhosphoSitePlusiO35912

Proteomic databases

PaxDbiO35912
PRIDEiO35912
TopDownProteomicsiO35912

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038876; ENSMUSP00000037289; ENSMUSG00000040212
ENSMUST00000164119; ENSMUSP00000132519; ENSMUSG00000040212
ENSMUST00000210297; ENSMUSP00000147800; ENSMUSG00000040212
GeneIDi13732
KEGGimmu:13732
UCSCiuc009gxv.2 mouse

Organism-specific databases

CTDi2014
MGIiMGI:1098729 Emp3

Phylogenomic databases

eggNOGiENOG410IY40 Eukaryota
ENOG4111MF9 LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiO35912
OMAiMEKSWWV
OrthoDBiEOG091G0RF4
TreeFamiTF330414

Miscellaneous databases

PROiPR:O35912
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040212 Expressed in 227 organ(s), highest expression level in adrenal gland
CleanExiMM_EMP3
ExpressionAtlasiO35912 baseline and differential
GenevisibleiO35912 MM

Family and domain databases

InterProiView protein in InterPro
IPR003934 EMP_3
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF8 PTHR10671:SF8, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01456 EPMEMPROT3
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMP3_MOUSE
AccessioniPrimary (citable) accession number: O35912
Secondary accession number(s): O88333, Q3UIF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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