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Protein

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Gene

Pik3cd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function.7 Publications

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

Activity regulationi

Activated by growth factors and cytokine receptors through a tyrosine-kinase-dependent mechanism. Activated by RAS. IC87114 inhibits lipid kinase activity and is selective in cells at doses up to 5-10 µM. Among other effects, IC87114 reduces allergic responses, prevents the recruitment of antigen-specific T cells into target tissue, and affects natural killer cell chemotaxis.3 Publications

Pathwayi: phosphatidylinositol phosphate biosynthesis

This protein is involved in the pathway phosphatidylinositol phosphate biosynthesis, which is part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol phosphate biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAdaptive immunity, Chemotaxis, Differentiation, Immunity, Inflammatory response, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.153 3474
ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8853659 RET signaling
R-MMU-912526 Interleukin receptor SHC signaling
R-MMU-912631 Regulation of signaling by CBL
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
UniPathwayi
UPA00220

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC:2.7.1.153)
Short name:
PI3-kinase subunit delta
Short name:
PI3K-delta
Short name:
PI3Kdelta
Short name:
PtdIns-3-kinase subunit delta
Alternative name(s):
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
Short name:
PtdIns-3-kinase subunit p110-delta
Short name:
p110delta
Gene namesi
Name:Pik3cd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098211 Pik3cd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Null mutants are viable and fertile but display defective adaptive and innate immune responses due to signaling defects in multiple cell types including B-, T- and mast and natural killer cells.5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi910D → A: Inhibits lipid kinase activity. Mice are viable and fertile but display defective adaptive and innate immune responses Signaling defects in B-cells, T-cells, mast cells and natural killer cells. Reduced B and T-cell receptor signaling. Affects development and differentiation of B -ells. Reduced memory T-cell number. Affects B- and T-cell proliferation. Attenuates immune responses in vivo. Induces inflammatory bowel disease development. Lost TCR-induced migration and localization to antigenic tissue. Affects natural killer cell maturation and cytokine production. 4 Publications1

Chemistry databases

ChEMBLiCHEMBL2216745

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887911 – 1043Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformAdd BLAST1043

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei523PhosphotyrosineBy similarity1
Modified residuei1038Phosphoserine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylation on Ser-1038 results in the almost complete inactivation of the lipid kinase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35904
MaxQBiO35904
PaxDbiO35904
PRIDEiO35904

PTM databases

iPTMnetiO35904
PhosphoSitePlusiO35904

Expressioni

Tissue specificityi

Isoform 1 is expressed in spleen and lung (at protein level). Isoform 1 is expressed predominantly in leukocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000039936 Expressed in 170 organ(s), highest expression level in primary oocyte
ExpressionAtlasiO35904 baseline and differential
GenevisibleiO35904 MM

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS and HRAS.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pik3r1P264502EBI-6470774,EBI-641764

Protein-protein interaction databases

BioGridi202161, 2 interactors
DIPiDIP-39841N
IntActiO35904, 8 interactors
STRINGi10090.ENSMUSP00000101315

Chemistry databases

BindingDBiO35904

Structurei

Secondary structure

11043
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35904
SMRiO35904
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35904

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 105PI3K-ABDPROSITE-ProRule annotationAdd BLAST90
Domaini187 – 278PI3K-RBDPROSITE-ProRule annotationAdd BLAST92
Domaini319 – 476C2 PI3K-typePROSITE-ProRule annotationAdd BLAST158
Domaini496 – 673PIK helicalPROSITE-ProRule annotationAdd BLAST178
Domaini775 – 1028PI3K/PI4KPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
HOGENOMiHOG000252911
HOVERGENiHBG052721
InParanoidiO35904
KOiK00922

Family and domain databases

CDDicd05174 PI3Kc_IA_delta, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR037703 PI3Kdelta_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O35904-1) [UniParc]FASTAAdd to basket
Also known as: p110-delta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW
60 70 80 90 100
HRAQYEPLFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA
160 170 180 190 200
AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLRVSNRAL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA LQVNGRHEYL
260 270 280 290 300
YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
310 320 330 340 350
AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG
360 370 380 390 400
NEMLCKTVSS SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK
410 420 430 440 450
AKKARSTKKK SKKADCPIAW ANLMLFDYKD QLKTGERCLY MWPSVPDEKG
460 470 480 490 500
ELLNPAGTVR GNPNTESAAA LVIYLPEVAP HPVYFPALEK ILELGRHGER
510 520 530 540 550
GRITEEELQL REILERRGSG ELYEHEKDLV WKMRHEVQEH FPEALARLLL
560 570 580 590 600
VTKWNKHEDV AQMLYLLCSW PELPVLSALE LLDFSFPDCY VGSFAIKSLR
610 620 630 640 650
KLTDDELFQY LLQLVQVLKY ESYLDCELTK FLLGRALANR KIGHFLFWHL
660 670 680 690 700
RSEMHVPSVA LRFGLIMEAY CRGSTHHMKV LMKQGEALSK LKALNDFVKV
710 720 730 740 750
SSQKTTKPQT KEMMHMCMRQ ETYMEALSHL QSPLDPSTLL EEVCVEQCTF
760 770 780 790 800
MDSKMKPLWI MYSSEEAGSA GNVGIIFKNG DDLRQDMLTL QMIQLMDVLW
810 820 830 840 850
KQEGLDLRMT PYGCLPTGDR TGLIEVVLHS DTIANIQLNK SNMAATAAFN
860 870 880 890 900
KDALLNWLKS KNPGEALDRA IEEFTLSCAG YCVATYVLGI GDRHSDNIMI
910 920 930 940 950
RESGQLFHID FGHFLGNFKT KFGINRERVP FILTYDFVHV IQQGKTNNSE
960 970 980 990 1000
KFERFRGYCE RAYTILRRHG LLFLHLFALM RAAGLPELSC SKDIQYLKDS
1010 1020 1030 1040
LALGKTEEEA LKHFRVKFNE ALRESWKTKV NWLAHNVSKD NRQ
Length:1,043
Mass (Da):119,712
Last modified:July 27, 2011 - v2
Checksum:iAD8DE07D8F847795
GO
Isoform 2 (identifier: O35904-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-212: ESFTFQVSTKDM → VSPSPIPSPSSI
     213-1043: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):24,355
Checksum:iF61391FD8427F323
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3T9Y0Q3T9Y0_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
1,047Annotation score:
Q3UDT3Q3UDT3_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
1,044Annotation score:
B0QZL5B0QZL5_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
1,040Annotation score:
Q3TBW3Q3TBW3_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
1,046Annotation score:
Q8CI98Q8CI98_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
1,045Annotation score:
B1AS24B1AS24_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
145Annotation score:
B1AS25B1AS25_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
171Annotation score:
B1AS26B1AS26_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
117Annotation score:
B1AS27B1AS27_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
62Annotation score:
B1AS28B1AS28_MOUSE
Phosphatidylinositol 4,5-bisphospha...
Pik3cd
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122G → A in AAC25676 (PubMed:9235916).Curated1
Sequence conflicti584F → S in AAC25676 (PubMed:9235916).Curated1
Sequence conflicti651R → H in AAC25676 (PubMed:9235916).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044411201 – 212ESFTF…STKDM → VSPSPIPSPSSI in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_044412213 – 1043Missing in isoform 2. CuratedAdd BLAST831

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86587 mRNA Translation: AAC25676.1
AF532989 Genomic DNA Translation: AAN05615.1
AL607078 Genomic DNA Translation: CAM23914.1
CU207384 Genomic DNA Translation: CAQ51667.1
CH466594 Genomic DNA Translation: EDL14872.1
CCDSiCCDS51380.1 [O35904-1]
PIRiT43502
RefSeqiNP_001157524.1, NM_001164052.1 [O35904-1]
XP_006538715.1, XM_006538652.3 [O35904-1]
UniGeneiMm.229108

Genome annotation databases

EnsembliENSMUST00000105689; ENSMUSP00000101314; ENSMUSG00000039936 [O35904-1]
GeneIDi18707
KEGGimmu:18707
UCSCiuc008vwq.1 mouse [O35904-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86587 mRNA Translation: AAC25676.1
AF532989 Genomic DNA Translation: AAN05615.1
AL607078 Genomic DNA Translation: CAM23914.1
CU207384 Genomic DNA Translation: CAQ51667.1
CH466594 Genomic DNA Translation: EDL14872.1
CCDSiCCDS51380.1 [O35904-1]
PIRiT43502
RefSeqiNP_001157524.1, NM_001164052.1 [O35904-1]
XP_006538715.1, XM_006538652.3 [O35904-1]
UniGeneiMm.229108

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WXFX-ray1.90A106-1043[»]
2WXGX-ray2.00A106-1043[»]
2WXHX-ray1.90A106-1043[»]
2WXIX-ray2.80A106-1043[»]
2WXJX-ray2.60A106-1043[»]
2WXKX-ray2.90A106-1043[»]
2WXLX-ray1.99A106-1043[»]
2WXMX-ray2.80A106-1043[»]
2WXNX-ray2.60A106-1043[»]
2WXOX-ray2.49A106-1043[»]
2WXPX-ray2.30A106-1043[»]
2WXQX-ray2.70A106-1043[»]
2WXRX-ray2.50A106-1043[»]
2X38X-ray2.20A106-1043[»]
4AJWX-ray2.80A/B110-1043[»]
4V0IX-ray2.54A/B106-1043[»]
4XE0X-ray2.43A106-1043[»]
5AE8X-ray2.42A106-1043[»]
5AE9X-ray2.44A106-1043[»]
5I4UX-ray2.37A106-1043[»]
5I6UX-ray2.84A106-1043[»]
5IS5X-ray2.85A1-1043[»]
5L72X-ray3.06A106-1043[»]
5NCYX-ray1.90A106-507[»]
A509-1043[»]
5NCZX-ray1.94A106-1043[»]
5NGBX-ray2.90A1-1043[»]
5O83X-ray2.90A106-1043[»]
5T27X-ray2.60A106-1043[»]
5T28X-ray2.80A106-507[»]
A509-1043[»]
5T2BX-ray2.30A106-1043[»]
5T2DX-ray2.90A106-1043[»]
5T2GX-ray2.55A106-1043[»]
5T2IX-ray2.30A106-1043[»]
5T2LX-ray2.55A106-1043[»]
5T2MX-ray2.80A106-1043[»]
5T7FX-ray2.60A/B106-1043[»]
5T8IX-ray2.60A106-1043[»]
6DGTX-ray2.60A106-1043[»]
6EZ6X-ray2.04A1-1043[»]
ProteinModelPortaliO35904
SMRiO35904
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202161, 2 interactors
DIPiDIP-39841N
IntActiO35904, 8 interactors
STRINGi10090.ENSMUSP00000101315

Chemistry databases

BindingDBiO35904
ChEMBLiCHEMBL2216745

PTM databases

iPTMnetiO35904
PhosphoSitePlusiO35904

Proteomic databases

EPDiO35904
MaxQBiO35904
PaxDbiO35904
PRIDEiO35904

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105689; ENSMUSP00000101314; ENSMUSG00000039936 [O35904-1]
GeneIDi18707
KEGGimmu:18707
UCSCiuc008vwq.1 mouse [O35904-1]

Organism-specific databases

CTDi5293
MGIiMGI:1098211 Pik3cd

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
HOGENOMiHOG000252911
HOVERGENiHBG052721
InParanoidiO35904
KOiK00922

Enzyme and pathway databases

UniPathwayi
UPA00220

BRENDAi2.7.1.153 3474
ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8853659 RET signaling
R-MMU-912526 Interleukin receptor SHC signaling
R-MMU-912631 Regulation of signaling by CBL
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRSiPik3cd mouse
EvolutionaryTraceiO35904
PROiPR:O35904
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039936 Expressed in 170 organ(s), highest expression level in primary oocyte
ExpressionAtlasiO35904 baseline and differential
GenevisibleiO35904 MM

Family and domain databases

CDDicd05174 PI3Kc_IA_delta, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR037703 PI3Kdelta_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPK3CD_MOUSE
AccessioniPrimary (citable) accession number: O35904
Secondary accession number(s): Q8CJ28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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