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Protein

C-C motif chemokine 25

Gene

Ccl25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: MGI
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: MGI
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
Gene namesi
Name:Ccl25
Synonyms:Scya25, Teck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1099448 Ccl25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000523624 – 144C-C motif chemokine 25Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO35903
PRIDEiO35903

PTM databases

PhosphoSitePlusiO35903

Expressioni

Tissue specificityi

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Gene expression databases

BgeeiENSMUSG00000023235 Expressed in 202 organ(s), highest expression level in small intestine
CleanExiMM_CCL25
ExpressionAtlasiO35903 baseline and differential
GenevisibleiO35903 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5885N
IntActiO35903, 5 interactors
MINTiO35903
STRINGi10090.ENSMUSP00000024004

Structurei

3D structure databases

ProteinModelPortaliO35903
SMRiO35903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J09B Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00900000141238
HOGENOMiHOG000293281
HOVERGENiHBG050832
InParanoidiO35903
KOiK13072
TreeFamiTF353160

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O35903-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLWLFACLV ACFVGAWMPV VHAQGAFEDC CLGYQHRIKW NVLRHARNYH
60 70 80 90 100
QQEVSGSCNL RAVRFYFRQK VVCGNPEDMN VKRAMRILTA RKRLVHWKSA
110 120 130 140
SDSQTERKKS NHMKSKVENP NSTSVRSATL GHPRMVMMPR KTNN
Length:144
Mass (Da):16,733
Last modified:September 18, 2013 - v2
Checksum:iCEC1924B320B4408
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWJ1D3YWJ1_MOUSE
C-C motif chemokine 25
Ccl25
228Annotation score:
D3Z470D3Z470_MOUSE
C-C motif chemokine 25
Ccl25
119Annotation score:
Q3V2F3Q3V2F3_MOUSE
C-C motif chemokine 25
Ccl25
134Annotation score:
F7C0M8F7C0M8_MOUSE
C-C motif chemokine 25
Ccl25
146Annotation score:
Q3U4J3Q3U4J3_MOUSE
C-C motif chemokine 25
Ccl25
89Annotation score:
A0A087WRS0A0A087WRS0_MOUSE
C-C motif chemokine 25
Ccl25
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85M → I in AAB69982 (PubMed:9285413).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86357 mRNA Translation: AAB69982.1
AJ249480 mRNA Translation: CAB55762.1
DQ158256 mRNA Translation: AAZ99719.1
AK134138 mRNA Translation: BAE22030.1
AC155164 Genomic DNA No translation available.
BC117033 mRNA Translation: AAI17034.1
BC117037 mRNA Translation: AAI17038.1
CCDSiCCDS22085.1
RefSeqiNP_033164.1, NM_009138.3
XP_011240345.2, XM_011242043.2
XP_011240346.2, XM_011242044.2
UniGeneiMm.7275

Genome annotation databases

EnsembliENSMUST00000024004; ENSMUSP00000024004; ENSMUSG00000023235
GeneIDi20300
KEGGimmu:20300
UCSCiuc009ktw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86357 mRNA Translation: AAB69982.1
AJ249480 mRNA Translation: CAB55762.1
DQ158256 mRNA Translation: AAZ99719.1
AK134138 mRNA Translation: BAE22030.1
AC155164 Genomic DNA No translation available.
BC117033 mRNA Translation: AAI17034.1
BC117037 mRNA Translation: AAI17038.1
CCDSiCCDS22085.1
RefSeqiNP_033164.1, NM_009138.3
XP_011240345.2, XM_011242043.2
XP_011240346.2, XM_011242044.2
UniGeneiMm.7275

3D structure databases

ProteinModelPortaliO35903
SMRiO35903
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5885N
IntActiO35903, 5 interactors
MINTiO35903
STRINGi10090.ENSMUSP00000024004

PTM databases

PhosphoSitePlusiO35903

Proteomic databases

PaxDbiO35903
PRIDEiO35903

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024004; ENSMUSP00000024004; ENSMUSG00000023235
GeneIDi20300
KEGGimmu:20300
UCSCiuc009ktw.2 mouse

Organism-specific databases

CTDi6370
MGIiMGI:1099448 Ccl25

Phylogenomic databases

eggNOGiENOG410J09B Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00900000141238
HOGENOMiHOG000293281
HOVERGENiHBG050832
InParanoidiO35903
KOiK13072
TreeFamiTF353160

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:O35903
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023235 Expressed in 202 organ(s), highest expression level in small intestine
CleanExiMM_CCL25
ExpressionAtlasiO35903 baseline and differential
GenevisibleiO35903 MM

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL25_MOUSE
AccessioniPrimary (citable) accession number: O35903
Secondary accession number(s): Q9QYY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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