UniProtKB - O35900 (LSM2_MOUSE)
U6 snRNA-associated Sm-like protein LSm2
Lsm2
Functioni
GO - Molecular functioni
- protein kinase binding Source: MGI
- RNA binding Source: UniProtKB-KW
- small GTPase binding Source: MGI
GO - Biological processi
- mRNA catabolic process Source: MGI
- mRNA splicing, via spliceosome Source: UniProtKB
- spliceosomal tri-snRNP complex assembly Source: MGI
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-MMU-430039, mRNA decay by 5' to 3' exoribonuclease R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72165, mRNA Splicing - Minor Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: U6 snRNA-associated Sm-like protein LSm2Alternative name(s): Protein G7b snRNP core Sm-like protein Sm-x5 |
Gene namesi | Name:Lsm2 Synonyms:G7b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
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Organism-specific databases
MGIi | MGI:90676, Lsm2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- catalytic step 2 spliceosome Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- precatalytic spliceosome Source: GO_Central
- U2-type precatalytic spliceosome Source: UniProtKB
- U4/U6 x U5 tri-snRNP complex Source: UniProtKB
- U6 snRNP Source: GO_Central
Other locations
- cytoplasm Source: MGI
- Lsm1-7-Pat1 complex Source: GO_Central
- Lsm2-8 complex Source: UniProtKB
- P-body Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125557 | 1 – 95 | U6 snRNA-associated Sm-like protein LSm2Add BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 79 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O35900 |
jPOSTi | O35900 |
PaxDbi | O35900 |
PeptideAtlasi | O35900 |
PRIDEi | O35900 |
ProteomicsDBi | 292047 |
2D gel databases
REPRODUCTION-2DPAGEi | O35900 |
PTM databases
iPTMneti | O35900 |
PhosphoSitePlusi | O35900 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000007050, Expressed in undifferentiated genital tubercle and 223 other tissues |
ExpressionAtlasi | O35900, baseline and differential |
Genevisiblei | O35900, MM |
Interactioni
Subunit structurei
Component of the precatalytic spliceosome (spliceosome B complex).
Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
By similarityGO - Molecular functioni
- protein kinase binding Source: MGI
- small GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 205506, 31 interactors |
STRINGi | 10090.ENSMUSP00000007266 |
Miscellaneous databases
RNActi | O35900, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3448, Eukaryota |
GeneTreei | ENSGT00390000016597 |
HOGENOMi | CLU_130474_3_0_1 |
InParanoidi | O35900 |
OMAi | EARYPHM |
PhylomeDBi | O35900 |
Family and domain databases
CDDi | cd01725, LSm2, 1 hit |
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR016654, U6_snRNA_Lsm2 |
PANTHERi | PTHR13829, PTHR13829, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF016394, U6_snRNA_Lsm2, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK
60 70 80 90
YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO35901 | O35901_MOUSE | G7b alternative form | Lsm2 G7b, Sm-X5, SmX5 | 131 | Annotation score: | ||
G3UZ96 | G3UZ96_MOUSE | U6 snRNA-associated Sm-like protein... | Lsm2 | 85 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85207 Genomic DNA Translation: AAB72037.1 AF397035 Genomic DNA Translation: AAL14450.1 AF397036 Genomic DNA Translation: AAL14458.1 BC014288 mRNA Translation: AAH14288.1 |
CCDSi | CCDS50081.1 |
RefSeqi | NP_001103571.1, NM_001110101.2 |
Genome annotation databases
Ensembli | ENSMUST00000114011; ENSMUSP00000109644; ENSMUSG00000007050 |
GeneIDi | 27756 |
KEGGi | mmu:27756 |
UCSCi | uc008cer.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85207 Genomic DNA Translation: AAB72037.1 AF397035 Genomic DNA Translation: AAL14450.1 AF397036 Genomic DNA Translation: AAL14458.1 BC014288 mRNA Translation: AAH14288.1 |
CCDSi | CCDS50081.1 |
RefSeqi | NP_001103571.1, NM_001110101.2 |
3D structure databases
SMRi | O35900 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205506, 31 interactors |
STRINGi | 10090.ENSMUSP00000007266 |
PTM databases
iPTMneti | O35900 |
PhosphoSitePlusi | O35900 |
2D gel databases
REPRODUCTION-2DPAGEi | O35900 |
Proteomic databases
EPDi | O35900 |
jPOSTi | O35900 |
PaxDbi | O35900 |
PeptideAtlasi | O35900 |
PRIDEi | O35900 |
ProteomicsDBi | 292047 |
Protocols and materials databases
Antibodypediai | 27800, 196 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000114011; ENSMUSP00000109644; ENSMUSG00000007050 |
GeneIDi | 27756 |
KEGGi | mmu:27756 |
UCSCi | uc008cer.3, mouse |
Organism-specific databases
CTDi | 57819 |
MGIi | MGI:90676, Lsm2 |
Phylogenomic databases
eggNOGi | KOG3448, Eukaryota |
GeneTreei | ENSGT00390000016597 |
HOGENOMi | CLU_130474_3_0_1 |
InParanoidi | O35900 |
OMAi | EARYPHM |
PhylomeDBi | O35900 |
Enzyme and pathway databases
Reactomei | R-MMU-430039, mRNA decay by 5' to 3' exoribonuclease R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72165, mRNA Splicing - Minor Pathway |
Miscellaneous databases
BioGRID-ORCSi | 27756, 22 hits in 50 CRISPR screens |
ChiTaRSi | Lsm2, mouse |
PROi | PR:O35900 |
RNActi | O35900, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007050, Expressed in undifferentiated genital tubercle and 223 other tissues |
ExpressionAtlasi | O35900, baseline and differential |
Genevisiblei | O35900, MM |
Family and domain databases
CDDi | cd01725, LSm2, 1 hit |
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR016654, U6_snRNA_Lsm2 |
PANTHERi | PTHR13829, PTHR13829, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF016394, U6_snRNA_Lsm2, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LSM2_MOUSE | |
Accessioni | O35900Primary (citable) accession number: O35900 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families