UniProtKB - O35881 (P2Y14_RAT)
Protein
P2Y purinoceptor 14
Gene
P2ry14
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for UDP-glucose coupled to G-proteins.By similarity
GO - Molecular functioni
- G protein-coupled purinergic nucleotide receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- immune response Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-417957, P2Y receptors R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: P2Y purinoceptor 14Short name: P2Y14 Alternative name(s): G-protein coupled receptor 105 UDP-glucose receptor VTR 15-20 |
Gene namesi | Name:P2ry14 Synonyms:Gpr105 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70912, P2ry14 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 51 – 55 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 56 – 76 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 96 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 97 – 117 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 139 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 188 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 189 – 209 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 234 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 235 – 255 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 256 – 278 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 279 – 299 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 300 – 305 | CytoplasmicSequence analysis | 6 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070046 | 1 – 305 | P2Y purinoceptor 14Add BLAST | 305 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | O35881 |
PTM databases
GlyGeni | O35881, 2 sites |
PhosphoSitePlusi | O35881 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | O35881 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR005466, P2Y14_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01655, UDPGLUCOSER |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O35881-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNTTTTEPP KQPCTRNTLI TQQIIPMLYC VVFITGVLLN GISGWIFFYV
60 70 80 90 100
PSSKSFIIYL KNIVVADFLM GLTFPFKVLS DSGLGPWQLN VFVFRVSAVI
110 120 130 140 150
FYVNMYVSIA FFGLISFDRY YKIVKPLLVS IVQSVNYSKV LSVLVWVLML
160 170 180 190 200
LLAVPNIILT NQSVKDVTNI QCMELKNELG RKWHKASNYV FVSIFWIVFL
210 220 230 240 250
LLTVFYMAIT RKIFKSHLKS RKNSISVKRK SSRNIFSIVL AFVACFAPYH
260 270 280 290 300
VARIPYTKSQ TEGHYSCQAK ETLLYTKEFT LLLSAANVCL DPISISSYAS
RLEKS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5XIX4 | Q5XIX4_RAT | P2Y purinoceptor 14 | P2ry14 rCG_50107 | 338 | Annotation score: | ||
A0A0G2K2N8 | A0A0G2K2N8_RAT | P2Y purinoceptor 14 | P2ry14 | 305 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76206 mRNA Translation: AAB71745.1 |
RefSeqi | NP_598261.1, NM_133577.1 |
Genome annotation databases
GeneIDi | 171108 |
KEGGi | rno:171108 |
UCSCi | RGD:70912, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76206 mRNA Translation: AAB71745.1 |
RefSeqi | NP_598261.1, NM_133577.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
ChEMBLi | CHEMBL4295660 |
GuidetoPHARMACOLOGYi | 330 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O35881, 2 sites |
PhosphoSitePlusi | O35881 |
Proteomic databases
PRIDEi | O35881 |
Genome annotation databases
GeneIDi | 171108 |
KEGGi | rno:171108 |
UCSCi | RGD:70912, rat |
Organism-specific databases
CTDi | 9934 |
RGDi | 70912, P2ry14 |
Phylogenomic databases
InParanoidi | O35881 |
Enzyme and pathway databases
Reactomei | R-RNO-417957, P2Y receptors R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:O35881 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR005466, P2Y14_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01655, UDPGLUCOSER |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P2Y14_RAT | |
Accessioni | O35881Primary (citable) accession number: O35881 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries