UniProtKB - O35876 (SMN_RAT)
Survival motor neuron protein
Smn1
Functioni
GO - Molecular functioni
- fibroblast growth factor binding Source: RGD
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- chemical synaptic transmission Source: RGD
- DNA-templated transcription, termination Source: UniProtKB
- nervous system development Source: UniProtKB-KW
- spliceosomal snRNP assembly Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing, Neurogenesis |
Enzyme and pathway databases
Reactomei | R-RNO-191859 snRNP Assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Survival motor neuron protein |
Gene namesi | Name:Smn1 Synonyms:Smn |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620755 Smn1 |
Subcellular locationi
Nucleus
- gem By similarity
- Cajal body By similarity
Other locations
- Cytoplasm By similarity
- Cytoplasmic granule By similarity
- Perikaryon By similarity
- neuron projection By similarity
- axon By similarity
- Z line By similarity
Note: Colocalizes with actin and at the Z-line of skeletal muscle. Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes.By similarity
Cytosol
- cytosol Source: UniProtKB
Nucleus
- Cajal body Source: UniProtKB
- Gemini of coiled bodies Source: RGD
- nucleolus Source: RGD
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- axon Source: UniProtKB-SubCell
- cytoplasm Source: RGD
- cytoplasmic ribonucleoprotein granule Source: UniProtKB
- neuron projection Source: UniProtKB
- perikaryon Source: UniProtKB
- SMN complex Source: UniProtKB
- SMN-Sm protein complex Source: UniProtKB
- Z disc Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218905 | 1 – 289 | Survival motor neuron proteinAdd BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Cross-linki | 49 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 67 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 205 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O35876 |
PaxDbi | O35876 |
PRIDEi | O35876 |
PTM databases
iPTMneti | O35876 |
PhosphoSitePlusi | O35876 |
Interactioni
Subunit structurei
Homodimer. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG.
Component of an import snRNP complex composed of KPNB1, RNUT1, SMN1 and ZNF259.
Interacts with DDX20, FBL, NOLA1, RNUT1 and with several spliceosomal snRNP core Sm proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE and ILF3.
Interacts with OSTF1, LSM10, LSM11 and RPP20/POP7.
Interacts (via C-terminal region) with ZPR1 (via C-terminal region).
Interacts (via Tudor domain) with COIL.
Interacts with SETX; recruits SETX to POLR2A.
Interacts with POLR2A (via the C-terminal domain (CTD)).
Interacts with PRMT5.
Interacts with XRN2.
Interacts (via C-terminus) with FMR1 (via C-terminus); the interaction is direct and occurs in a RNA-independent manner.
Interacts with SYNCRIP.
Interacts (via Tudor domain) with SF3B2 (methylated form).
Interacts with WRAP53/TCAB1 (By similarity).
Interacts (via Tudor domain) with ELAVL4 in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules (PubMed:21389246).
By similarity1 PublicationGO - Molecular functioni
- fibroblast growth factor binding Source: RGD
Protein-protein interaction databases
BioGridi | 249016, 1 interactor |
IntActi | O35876, 1 interactor |
STRINGi | 10116.ENSRNOP00000024456 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 89 – 149 | TudorPROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 11 – 42 | P1 (binding site for GEMIN2)By similarityAdd BLAST | 32 | |
Regioni | 95 – 205 | Required for interaction with RPP20/POP7By similarityAdd BLAST | 111 | |
Regioni | 235 – 262 | P2 (binding site for SM B)By similarityAdd BLAST | 28 | |
Regioni | 274 – 289 | Required for interaction with SYNCRIPBy similarityAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 197 | Poly-Pro | 7 | |
Compositional biasi | 213 – 222 | Poly-Pro | 10 | |
Compositional biasi | 239 – 243 | Poly-Pro | 5 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4327 Eukaryota ENOG4111ME8 LUCA |
HOGENOMi | HOG000232199 |
InParanoidi | O35876 |
KOi | K13129 |
OrthoDBi | 1316275at2759 |
PhylomeDBi | O35876 |
Family and domain databases
InterProi | View protein in InterPro IPR010304 Survival_motor_neuron IPR002999 Tudor |
Pfami | View protein in Pfam PF06003 SMN, 1 hit |
SMARTi | View protein in SMART SM00333 TUDOR, 1 hit |
PROSITEi | View protein in PROSITE PS50304 TUDOR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAMGSGGGAG SEQEDTVLFR RGTGQSDDSD IWDDTALIKA YDKAVASFKH
60 70 80 90 100
ALKNGDMCET SDKPKGTARR KPAKKNKNQK KNATAPLKQW KAGDKCSAVW
110 120 130 140 150
SEDGCVYPAT ITSVDLKRET CVVVYTGYGN KEEQNLSDLL SPTCEVANNT
160 170 180 190 200
EQNTQENESQ VSTDDSEHSS RSLRSKAHSK SKAAPWTSFL PPPPPVPGAG
210 220 230 240 250
LGPGKPGLRF SGPPPPPPPP PPFLPCWMPP FPSGPPIIPP PPPISPDCLD
260 270 280
DTDALGSMLI SWYMSGYHTG YYMGFRQNKK EGKKCSHTN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6P684 | Q6P684_RAT | Survival motor neuron 1 | Smn1 rCG_44549 | 288 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | Missing in AAC01747 (PubMed:9758161).Curated | 1 | |
Sequence conflicti | 65 | K → E in AAC01747 (PubMed:9758161).Curated | 1 | |
Sequence conflicti | 211 | S → N in AAC01747 (PubMed:9758161).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75369 mRNA Translation: AAB96377.1 AF044910 mRNA Translation: AAC01747.1 |
RefSeqi | NP_071954.1, NM_022509.1 |
Genome annotation databases
GeneIDi | 64301 |
KEGGi | rno:64301 |
UCSCi | RGD:620755 rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75369 mRNA Translation: AAB96377.1 AF044910 mRNA Translation: AAC01747.1 |
RefSeqi | NP_071954.1, NM_022509.1 |
3D structure databases
SMRi | O35876 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 249016, 1 interactor |
IntActi | O35876, 1 interactor |
STRINGi | 10116.ENSRNOP00000024456 |
PTM databases
iPTMneti | O35876 |
PhosphoSitePlusi | O35876 |
Proteomic databases
jPOSTi | O35876 |
PaxDbi | O35876 |
PRIDEi | O35876 |
Genome annotation databases
GeneIDi | 64301 |
KEGGi | rno:64301 |
UCSCi | RGD:620755 rat |
Organism-specific databases
CTDi | 6606 |
RGDi | 620755 Smn1 |
Phylogenomic databases
eggNOGi | KOG4327 Eukaryota ENOG4111ME8 LUCA |
HOGENOMi | HOG000232199 |
InParanoidi | O35876 |
KOi | K13129 |
OrthoDBi | 1316275at2759 |
PhylomeDBi | O35876 |
Enzyme and pathway databases
Reactomei | R-RNO-191859 snRNP Assembly |
Miscellaneous databases
PROi | PR:O35876 |
Family and domain databases
InterProi | View protein in InterPro IPR010304 Survival_motor_neuron IPR002999 Tudor |
Pfami | View protein in Pfam PF06003 SMN, 1 hit |
SMARTi | View protein in SMART SM00333 TUDOR, 1 hit |
PROSITEi | View protein in PROSITE PS50304 TUDOR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMN_RAT | |
Accessioni | O35876Primary (citable) accession number: O35876 Secondary accession number(s): O55045 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | November 13, 2019 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families