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Protein

Neutral amino acid transporter A

Gene

Slc1a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter A
Alternative name(s):
Alanine/serine/cysteine/threonine transporter 1
Short name:
ASCT-1
SATT
Solute carrier family 1 member 4
Gene namesi
Name:Slc1a4
Synonyms:Asct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2135601 Slc1a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 216ExtracellularSequence analysisAdd BLAST77
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020801 – 532Neutral amino acid transporter AAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi201N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi206N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei507PhosphoserineBy similarity1
Modified residuei527PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO35874
PaxDbiO35874
PeptideAtlasiO35874
PRIDEiO35874

PTM databases

iPTMnetiO35874
PhosphoSitePlusiO35874
SwissPalmiO35874

Expressioni

Gene expression databases

BgeeiENSMUSG00000020142 Expressed in 278 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiO35874 baseline and differential
GenevisibleiO35874 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105223

Structurei

3D structure databases

ProteinModelPortaliO35874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiO35874
KOiK05615
OMAiIMNLAPY
OrthoDBiEOG091G0UCE
PhylomeDBiO35874
TreeFamiTF315206

Family and domain databases

InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSGETNGY LDGTQAEPAA GPRTPETAMG KSQRCASFFR RHALVLLTVS
60 70 80 90 100
GVLVGAGMGA ALRGLQLTRT QITYLAFPGE MLLRMLRMII LPLVVCSLVS
110 120 130 140 150
GAASLDASSL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGAGAQTLQS
160 170 180 190 200
SSLGLENSGP PPVSKETVDS FLDLLRNLFP SNLVVAAFTT SATDYTVVTH
210 220 230 240 250
NTSSGNVTKE KIPVVTDVEG MNILGLVLFA LVLGVALKKL GPEGEDLIRF
260 270 280 290 300
FNSFNEATMV LVSWIMWYVP IGIMFLIGSK IVEMKDIVML VTSLGKYIFA
310 320 330 340 350
SMLGHVIHGG IVLPLVYFAF TRKNPFTFLL GLLTPFATAF ATCSSSATLP
360 370 380 390 400
SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVD
410 420 430 440 450
LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLSLILA
460 470 480 490 500
VDWIVDRTTT VVNVEGDALG AGILNHLNQK VVKKGEQELQ EVKVEAIPNS
510 520 530
KSEEETSPLV THQNPAGPVA IAPELESKES VL
Length:532
Mass (Da):56,062
Last modified:January 1, 1998 - v1
Checksum:i99DD9E43C5DB55D7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SSP3Q5SSP3_MOUSE
Neutral amino acid transporter A
Slc1a4
452Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75215 mRNA Translation: AAB71740.1
BC052733 mRNA Translation: AAH52733.1
CCDSiCCDS24457.1
RefSeqiNP_061349.3, NM_018861.3
UniGeneiMm.6379

Genome annotation databases

EnsembliENSMUST00000109594; ENSMUSP00000105223; ENSMUSG00000020142
GeneIDi55963
KEGGimmu:55963
UCSCiuc007idb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75215 mRNA Translation: AAB71740.1
BC052733 mRNA Translation: AAH52733.1
CCDSiCCDS24457.1
RefSeqiNP_061349.3, NM_018861.3
UniGeneiMm.6379

3D structure databases

ProteinModelPortaliO35874
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105223

PTM databases

iPTMnetiO35874
PhosphoSitePlusiO35874
SwissPalmiO35874

Proteomic databases

EPDiO35874
PaxDbiO35874
PeptideAtlasiO35874
PRIDEiO35874

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109594; ENSMUSP00000105223; ENSMUSG00000020142
GeneIDi55963
KEGGimmu:55963
UCSCiuc007idb.2 mouse

Organism-specific databases

CTDi6509
MGIiMGI:2135601 Slc1a4

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiO35874
KOiK05615
OMAiIMNLAPY
OrthoDBiEOG091G0UCE
PhylomeDBiO35874
TreeFamiTF315206

Enzyme and pathway databases

ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRSiSlc1a4 mouse
PROiPR:O35874
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020142 Expressed in 278 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiO35874 baseline and differential
GenevisibleiO35874 MM

Family and domain databases

InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSATT_MOUSE
AccessioniPrimary (citable) accession number: O35874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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