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Protein

Branched-chain-amino-acid aminotransferase, mitochondrial

Gene

Bcat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.1 Publication

Catalytic activityi

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

SABIO-RKiO35854

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferase, mitochondrial (EC:2.6.1.42)
Short name:
BCAT(m)
Gene namesi
Name:Bcat2
Synonyms:Bcatm, Eca40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68948 Bcat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionAdd BLAST27
ChainiPRO_000000127428 – 393Branched-chain-amino-acid aminotransferase, mitochondrialAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei322N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO35854
PRIDEiO35854

PTM databases

iPTMnetiO35854
PhosphoSitePlusiO35854

Expressioni

Tissue specificityi

Expressed in all tissues.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO35854, 1 interactor
STRINGi10116.ENSRNOP00000028474

Chemistry databases

BindingDBiO35854

Structurei

3D structure databases

ProteinModelPortaliO35854
SMRiO35854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0975 Eukaryota
COG0115 LUCA
HOGENOMiHOG000276704
HOVERGENiHBG050678
InParanoidiO35854
KOiK00826
PhylomeDBiO35854

Family and domain databases

CDDicd01557 BCAT_beta_family, 1 hit
InterProiView protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005786 B_amino_transII
IPR033939 BCAT_family
PfamiView protein in Pfam
PF01063 Aminotran_4, 1 hit
PIRSFiPIRSF006468 BCAT1, 1 hit
SUPFAMiSSF56752 SSF56752, 1 hit
TIGRFAMsiTIGR01123 ilvE_II, 1 hit
PROSITEiView protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O35854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAILGQVW TRKLLPIPWR LCVPGRCVSS NFKAADLQVQ VTREPQKKPA
60 70 80 90 100
PSQPLLFGKT FTDHMLMVEW NSKTGWGPPR IQPFQNLTLH PACSGLHYSL
110 120 130 140 150
QLFEGLKAYK GRDKQVRLFR PWLNMDRMLR SARRLCLPDF DKQELLECIR
160 170 180 190 200
QLIEVDKDWV PDGNGTSLYV RPVLIGNEPS LGVGMVTQAL LFVILCPVGS
210 220 230 240 250
YFPGDSMTPV SLLADPSFVR AWIGGVGDCK LGGNYGPTVA VQQEAQKKGC
260 270 280 290 300
EQVLWLYGPD HQLTEVGTMN IFVYWTHEDG ELELATPPLD GIILPGVVRQ
310 320 330 340 350
SLLDLARTWG EFRVAERKVT MKELKRALEE GRVREVFGSG TACQVCPVHQ
360 370 380 390
ILYEGKQLHI PTMENGPELI LRFQKELKAI QYGTSAHDWM LRV
Length:393
Mass (Da):44,276
Last modified:January 1, 1998 - v1
Checksum:iECB3704ED49A6C12
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8U8G3V8U8_RAT
Branched-chain-amino-acid aminotran...
Bcat2 rCG_53622
393Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68417 mRNA Translation: AAB67673.1
RefSeqiNP_071795.1, NM_022400.1
UniGeneiRn.981

Genome annotation databases

GeneIDi64203
KEGGirno:64203
UCSCiRGD:68948 rat

Similar proteinsi

Entry informationi

Entry nameiBCAT2_RAT
AccessioniPrimary (citable) accession number: O35854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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