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Protein

Apoptosis inhibitor 5

Gene

Api5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis inhibitor 5
Short name:
API-5
Alternative name(s):
AAC-11
Gene namesi
Name:Api5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1888993 Api5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646351 – 504Apoptosis inhibitor 5Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251N6-acetyllysineBy similarity1
Modified residuei399PhosphothreonineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1

Post-translational modificationi

Acetylation at Lys-251 impairs antiapoptotic function.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35841
MaxQBiO35841
PaxDbiO35841
PeptideAtlasiO35841
PRIDEiO35841

PTM databases

iPTMnetiO35841
PhosphoSitePlusiO35841

Expressioni

Inductioni

Down-regulated in vascular smooth muscle cells (vSMCs) treated with benzo[a]pyrene (BaP).1 Publication

Gene expression databases

BgeeiENSMUSG00000027193 Expressed in 295 organ(s), highest expression level in optic fissure
CleanExiMM_API5
GenevisibleiO35841 MM

Interactioni

Subunit structurei

Monomer. Interacts with FGF2 and ACIN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35841, 1 interactor
MINTiO35841
STRINGi10090.ENSMUSP00000028617

Structurei

3D structure databases

ProteinModelPortaliO35841
SMRiO35841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 360ARM-like and Heat-like helical repeatsBy similarityAdd BLAST360
Regioni370 – 391Leucine-zipperAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi454 – 475Nuclear localization signalBy similarityAdd BLAST22

Sequence similaritiesi

Belongs to the API5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2213 Eukaryota
ENOG410XSH0 LUCA
GeneTreeiENSGT00390000010991
HOVERGENiHBG050542
InParanoidiO35841
OMAiNRSRGRI
OrthoDBiEOG091G06NK
TreeFamiTF324283

Family and domain databases

InterProiView protein in InterPro
IPR008383 API5
IPR016024 ARM-type_fold
PANTHERiPTHR12758:SF19 PTHR12758:SF19, 1 hit
PfamiView protein in Pfam
PF05918 API5, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

O35841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP
60 70 80 90 100
KFFKHFPELA DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD
110 120 130 140 150
ILTQLLQTDD SAEFNLVNNA LLSIFKMDAK GTLGGLFSQI LQGEDIVRER
160 170 180 190 200
AIKFLSTKLK TLPDEVLTKE VEELILTESK KVLEDVTGEE FVLFMKILSG
210 220 230 240 250
LKSLQTVSGR QQLVELVAEQ ADLEQAFSPS DPDCVDRLLQ CTRQAVPLFS
260 270 280 290 300
KNVHSTRFVT YFCEQVLPNL STLTTPVEGL DIQLEVLKLL AEMSSFCGDM
310 320 330 340 350
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF
360 370 380 390 400
HQLGRKLPDF LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG
410 420 430 440 450
EALKTEENKI KVVALKITNN INVLIKDLFH IPPSYKSTVT LSWKPVQKVE
460 470 480 490 500
IGQKRTSEDT SSGSPPKKSP GGPKRDARQI YNPPSGKYSS NLSNFNYERS

LQGK
Length:504
Mass (Da):56,785
Last modified:July 27, 2011 - v2
Checksum:i11E4CC89509487B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288K → N in AAB86526 (PubMed:9307294).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35846 mRNA Translation: AAB86526.1
AK137466 mRNA Translation: BAE23364.1
AK153934 mRNA Translation: BAE32263.1
AK167375 mRNA Translation: BAE39470.1
AL672251 Genomic DNA Translation: CAM16211.1
CH466519 Genomic DNA Translation: EDL27645.1
BC007133 mRNA Translation: AAH07133.1
CCDSiCCDS16459.1
RefSeqiNP_031492.2, NM_007466.3
UniGeneiMm.181824
Mm.486651

Genome annotation databases

EnsembliENSMUST00000028617; ENSMUSP00000028617; ENSMUSG00000027193
GeneIDi11800
KEGGimmu:11800
UCSCiuc008lgx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35846 mRNA Translation: AAB86526.1
AK137466 mRNA Translation: BAE23364.1
AK153934 mRNA Translation: BAE32263.1
AK167375 mRNA Translation: BAE39470.1
AL672251 Genomic DNA Translation: CAM16211.1
CH466519 Genomic DNA Translation: EDL27645.1
BC007133 mRNA Translation: AAH07133.1
CCDSiCCDS16459.1
RefSeqiNP_031492.2, NM_007466.3
UniGeneiMm.181824
Mm.486651

3D structure databases

ProteinModelPortaliO35841
SMRiO35841
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35841, 1 interactor
MINTiO35841
STRINGi10090.ENSMUSP00000028617

PTM databases

iPTMnetiO35841
PhosphoSitePlusiO35841

Proteomic databases

EPDiO35841
MaxQBiO35841
PaxDbiO35841
PeptideAtlasiO35841
PRIDEiO35841

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028617; ENSMUSP00000028617; ENSMUSG00000027193
GeneIDi11800
KEGGimmu:11800
UCSCiuc008lgx.2 mouse

Organism-specific databases

CTDi8539
MGIiMGI:1888993 Api5

Phylogenomic databases

eggNOGiKOG2213 Eukaryota
ENOG410XSH0 LUCA
GeneTreeiENSGT00390000010991
HOVERGENiHBG050542
InParanoidiO35841
OMAiNRSRGRI
OrthoDBiEOG091G06NK
TreeFamiTF324283

Miscellaneous databases

ChiTaRSiApi5 mouse
PROiPR:O35841
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027193 Expressed in 295 organ(s), highest expression level in optic fissure
CleanExiMM_API5
GenevisibleiO35841 MM

Family and domain databases

InterProiView protein in InterPro
IPR008383 API5
IPR016024 ARM-type_fold
PANTHERiPTHR12758:SF19 PTHR12758:SF19, 1 hit
PfamiView protein in Pfam
PF05918 API5, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPI5_MOUSE
AccessioniPrimary (citable) accession number: O35841
Secondary accession number(s): Q3U517, Q922L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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