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Protein

Cyclin-dependent kinase 18

Gene

Cdk18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei150ATPPROSITE-ProRule annotation1
Active sitei242Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi127 – 135ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:Cdk18
Synonyms:Pctaire3, Pctk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309523 Cdk18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864931 – 451Cyclin-dependent kinase 18Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei109PhosphoserineBy similarity1
Modified residuei417PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35832
PRIDEiO35832

PTM databases

iPTMnetiO35832
PhosphoSitePlusiO35832

Expressioni

Tissue specificityi

In brain, kidney, intestine and at a much lower level, in fetal tissues.

Gene expression databases

GenevisibleiO35832 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010976

Structurei

3D structure databases

ProteinModelPortaliO35832
SMRiO35832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 402Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiO35832
KOiK15596
OrthoDBiEOG091G0CH0
PhylomeDBiO35832
TreeFamiTF106508

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35832-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKMKNFKRR LSLSVPRPET IEESLTEFTE QFNQLHTQRN EDGRDEPGQL
60 70 80 90 100
SPGVQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP
110 120 130 140 150
LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK
160 170 180 190 200
EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD
210 220 230 240 250
SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH RDLKPQNLLI
260 270 280 290 300
NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID
310 320 330 340 350
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE
360 370 380 390 400
FRAYNFPRYL PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP
410 420 430 440 450
YFQSLGERVH QLDDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI

F
Length:451
Mass (Da):51,882
Last modified:January 1, 1998 - v1
Checksum:iC3E4688F51B142E8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHG4A0A0H2UHG4_RAT
Cyclin-dependent kinase 18
Cdk18
465Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005541 mRNA Translation: BAA21472.1
RefSeqiNP_001093976.1, NM_001100506.1
XP_006249813.1, XM_006249751.3
UniGeneiRn.219420

Genome annotation databases

GeneIDi289019
KEGGirno:289019
UCSCiRGD:1309523 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005541 mRNA Translation: BAA21472.1
RefSeqiNP_001093976.1, NM_001100506.1
XP_006249813.1, XM_006249751.3
UniGeneiRn.219420

3D structure databases

ProteinModelPortaliO35832
SMRiO35832
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010976

PTM databases

iPTMnetiO35832
PhosphoSitePlusiO35832

Proteomic databases

PaxDbiO35832
PRIDEiO35832

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi289019
KEGGirno:289019
UCSCiRGD:1309523 rat

Organism-specific databases

CTDi5129
RGDi1309523 Cdk18

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiO35832
KOiK15596
OrthoDBiEOG091G0CH0
PhylomeDBiO35832
TreeFamiTF106508

Enzyme and pathway databases

BRENDAi2.7.11.22 5301

Miscellaneous databases

PROiPR:O35832

Gene expression databases

GenevisibleiO35832 RN

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKD18_RAT
AccessioniPrimary (citable) accession number: O35832
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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