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Protein

Amyloid-beta A4 precursor protein-binding family B member 3

Gene

Apbb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May modulate the internalization of amyloid-beta precursor protein.

GO - Molecular functioni

  • amyloid-beta binding Source: RGD
  • transcription factor binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family B member 3
Alternative name(s):
Protein Fe65-like 2
Short name:
Fe65L2
Gene namesi
Name:Apbb3
Synonyms:Fe65l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620853 Apbb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760561 – 504Amyloid-beta A4 precursor protein-binding family B member 3Add BLAST504

Proteomic databases

PaxDbiO35827
PRIDEiO35827

Expressioni

Tissue specificityi

Expressed predominantly in brain and testis.

Interactioni

Subunit structurei

Binds to the intracellular domain of the amyloid-beta precursor protein. Also binds to APP-like proteins.

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35827, 2 interactors
STRINGi10116.ENSRNOP00000024313

Structurei

3D structure databases

ProteinModelPortaliO35827
SMRiO35827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 61WWPROSITE-ProRule annotationAdd BLAST33
Domaini111 – 278PID 1PROSITE-ProRule annotationAdd BLAST168
Domaini283 – 438PID 2PROSITE-ProRule annotationAdd BLAST156

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiO35827
PhylomeDBiO35827

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O35827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP
60 70 80 90 100
SGSTQWQRPT WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW
110 120 130 140 150
YNEDSYVRSL EPGAKCFAVR SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ
160 170 180 190 200
ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL NPLDHSLIHC QPLVHIRVWG
210 220 230 240 250
VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR LQGLCAQILS
260 270 280 290 300
ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT
310 320 330 340 350
KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE
360 370 380 390 400
PLWQCPVRLV TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA
410 420 430 440 450
VQAACMVQYQ KCLVASAARG KAWGAQARAR LRLKRTSSMD SPGGPLPPPL
460 470 480 490 500
LKGGVGGAGA APRKRGVFSF LDAFRLKPLF SICPKLILEG WGKRLYTLPV

PRVL
Length:504
Mass (Da):54,907
Last modified:January 1, 1998 - v1
Checksum:iA49CA9E99BDB3A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13413 mRNA Translation: CAA73837.1
RefSeqiNP_446409.1, NM_053957.1
UniGeneiRn.30067

Genome annotation databases

GeneIDi117026
KEGGirno:117026
UCSCiRGD:620853 rat

Similar proteinsi

Entry informationi

Entry nameiAPBB3_RAT
AccessioniPrimary (citable) accession number: O35827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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