Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 148 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Latent-transforming growth factor beta-binding protein 2

Gene

Ltbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an integral structural role in elastic-fiber architectural organization and/or assembly.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding, Heparin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2129379, Molecules associated with elastic fibres

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 2
Short name:
LTBP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ltbp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
68380, Ltbp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 351 PublicationAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000764536 – 1764Latent-transforming growth factor beta-binding protein 2Add BLAST1729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi185 ↔ 195PROSITE-ProRule annotation
Disulfide bondi189 ↔ 201PROSITE-ProRule annotation
Disulfide bondi203 ↔ 212PROSITE-ProRule annotation
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi387 ↔ 397PROSITE-ProRule annotation
Disulfide bondi391 ↔ 403PROSITE-ProRule annotation
Disulfide bondi405 ↔ 414PROSITE-ProRule annotation
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei493PhosphoserineCombined sources1
Disulfide bondi540 ↔ 562PROSITE-ProRule annotation
Disulfide bondi549 ↔ 575PROSITE-ProRule annotation
Disulfide bondi563 ↔ 578PROSITE-ProRule annotation
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi612 ↔ 623PROSITE-ProRule annotation
Disulfide bondi618 ↔ 632PROSITE-ProRule annotation
Disulfide bondi634 ↔ 647PROSITE-ProRule annotation
Disulfide bondi660 ↔ 682PROSITE-ProRule annotation
Disulfide bondi669 ↔ 695PROSITE-ProRule annotation
Disulfide bondi683 ↔ 698PROSITE-ProRule annotation
Disulfide bondi684 ↔ 710PROSITE-ProRule annotation
Disulfide bondi838 ↔ 851PROSITE-ProRule annotation
Disulfide bondi846 ↔ 860PROSITE-ProRule annotation
Disulfide bondi862 ↔ 875PROSITE-ProRule annotation
Disulfide bondi881 ↔ 892PROSITE-ProRule annotation
Disulfide bondi886 ↔ 901PROSITE-ProRule annotation
Disulfide bondi903 ↔ 918PROSITE-ProRule annotation
Disulfide bondi924 ↔ 935PROSITE-ProRule annotation
Disulfide bondi930 ↔ 944PROSITE-ProRule annotation
Disulfide bondi946 ↔ 958PROSITE-ProRule annotation
Disulfide bondi964 ↔ 975PROSITE-ProRule annotation
Disulfide bondi970 ↔ 984PROSITE-ProRule annotation
Disulfide bondi987 ↔ 998PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1010 ↔ 1024PROSITE-ProRule annotation
Disulfide bondi1026 ↔ 1039PROSITE-ProRule annotation
Disulfide bondi1045 ↔ 1056PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1065PROSITE-ProRule annotation
Disulfide bondi1068 ↔ 1081PROSITE-ProRule annotation
Disulfide bondi1087 ↔ 1098PROSITE-ProRule annotation
Disulfide bondi1093 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1110 ↔ 1123PROSITE-ProRule annotation
Disulfide bondi1129 ↔ 1141PROSITE-ProRule annotation
Disulfide bondi1136 ↔ 1150PROSITE-ProRule annotation
Disulfide bondi1152 ↔ 1164PROSITE-ProRule annotation
Glycosylationi1160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1170 ↔ 1182PROSITE-ProRule annotation
Disulfide bondi1176 ↔ 1191PROSITE-ProRule annotation
Disulfide bondi1193 ↔ 1206PROSITE-ProRule annotation
Disulfide bondi1212 ↔ 1223PROSITE-ProRule annotation
Disulfide bondi1218 ↔ 1232PROSITE-ProRule annotation
Disulfide bondi1234 ↔ 1247PROSITE-ProRule annotation
Disulfide bondi1253 ↔ 1265PROSITE-ProRule annotation
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1259 ↔ 1274PROSITE-ProRule annotation
Disulfide bondi1276 ↔ 1289PROSITE-ProRule annotation
Disulfide bondi1295 ↔ 1307PROSITE-ProRule annotation
Disulfide bondi1302 ↔ 1316PROSITE-ProRule annotation
Disulfide bondi1318 ↔ 1332PROSITE-ProRule annotation
Disulfide bondi1359 ↔ 1382PROSITE-ProRule annotation
Disulfide bondi1369 ↔ 1394PROSITE-ProRule annotation
Glycosylationi1376N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1383 ↔ 1397PROSITE-ProRule annotation
Disulfide bondi1435 ↔ 1448PROSITE-ProRule annotation
Disulfide bondi1443 ↔ 1457PROSITE-ProRule annotation
Disulfide bondi1459 ↔ 1472PROSITE-ProRule annotation
Disulfide bondi1478 ↔ 1488PROSITE-ProRule annotation
Disulfide bondi1483 ↔ 1497PROSITE-ProRule annotation
Disulfide bondi1499 ↔ 1512PROSITE-ProRule annotation
Glycosylationi1514N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1532 ↔ 1555PROSITE-ProRule annotation
Disulfide bondi1541 ↔ 1567PROSITE-ProRule annotation
Disulfide bondi1556 ↔ 1570PROSITE-ProRule annotation
Disulfide bondi1557 ↔ 1582PROSITE-ProRule annotation
Disulfide bondi1680 ↔ 1691PROSITE-ProRule annotation
Disulfide bondi1686 ↔ 1700PROSITE-ProRule annotation
Disulfide bondi1702 ↔ 1715PROSITE-ProRule annotation
Disulfide bondi1721 ↔ 1736PROSITE-ProRule annotation
Disulfide bondi1731 ↔ 1745PROSITE-ProRule annotation
Disulfide bondi1747 ↔ 1760PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-Glycosylated.By similarity
Contains hydroxylated asparagine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35806

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O35806, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35806

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O35806

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cortical astrocytes and glioma cells. Expression is up-regulated by TGFB1.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex.

Interacts with SDC4.

Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000038437

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O35806

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 213EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini383 – 415EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini538 – 590TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini608 – 648EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini658 – 710TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini834 – 876EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Domaini877 – 919EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini920 – 959EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini960 – 999EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1000 – 1040EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1041 – 1082EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1083 – 1124EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1125 – 1165EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1166 – 1207EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1208 – 1248EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1249 – 1290EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1291 – 1333EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1357 – 1409TB 3PROSITE-ProRule annotationAdd BLAST53
Domaini1431 – 1473EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1474 – 1513EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1530 – 1582TB 4PROSITE-ProRule annotationAdd BLAST53
Domaini1676 – 1716EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1717 – 1761EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 140DisorderedSequence analysisAdd BLAST61
Regioni94 – 115Heparin-bindingBy similarityAdd BLAST22
Regioni220 – 279DisorderedSequence analysisAdd BLAST60
Regioni226 – 243Heparin-bindingBy similarityAdd BLAST18
Regioni331 – 341Heparin-bindingBy similarityAdd BLAST11
Regioni484 – 529DisorderedSequence analysisAdd BLAST46
Regioni729 – 759DisorderedSequence analysisAdd BLAST31
Regioni786 – 809DisorderedSequence analysisAdd BLAST24
Regioni1585 – 1764C-terminal domainBy similarityAdd BLAST180

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 132Polar residuesSequence analysisAdd BLAST23
Compositional biasi484 – 502Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTBP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O35806

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O35806

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 2 hits
PF07645, EGF_CA, 14 hits
PF12661, hEGF, 1 hit
PF00683, TB, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 19 hits
SM00179, EGF_CA, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 4 hits
SSF57581, SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00010, ASX_HYDROXYL, 12 hits
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 15 hits
PS51364, TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O35806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPTTVRCS GRIQRARWRG FLPLVLALLM GTSHAQRDSV GRYEPASRDA
60 70 80 90 100
NRLWRPVGNH PAAAAAKVYS LFREPDAPVP GLSPSEWNQP GQGIPGRLAE
110 120 130 140 150
AEARRPSRAQ QLRRVQSPVQ TRRSNPRGQQ PPAARTAHSV VRLATPQRPA
160 170 180 190 200
AARRGRLTGR NVCGGQCCPG WTTSNSTNHC IKPVCQPPCQ NRGSCSRPQL
210 220 230 240 250
CICRSGFRGA RCEEVIPEEE FDPQNARPVP RRSVEGAPGP HRSSEARGSL
260 270 280 290 300
VTRIQPLLPP LPPPPSRTLS QTRPLQQHAG LSRTVRRYPA TGTNGQLMSN
310 320 330 340 350
ALPSGPGPEL RDSSQQAAHM NHLSHPWGLN LTEKIKKIKV VFTPTICKQT
360 370 380 390 400
CARGRCANTC EKGDTTTLYS QGGHGHDPKS GFRIYFCQIP CLNGGRCIGR
410 420 430 440 450
DECWCPANST GKFCHLPVPQ PDREPPGRGS QHRALLEGPL KQSTFTLPLS
460 470 480 490 500
NQLASVNPSL VKVQMQHPPE ASVQIHQVAR VRGEVDPVPE DNSVETRASH
510 520 530 540 550
RPHGSSGHSH WASNSIPARA GEAPRPPPVP SRHYGLLGQC YLSTVNGQCA
560 570 580 590 600
NPLGELTSQE DCCGSVGTSW GVTSCAPCPP RPAFPVIENG QLECPQGYKR
610 620 630 640 650
LNLSHCQDIN ECLTLGLCKD SECVNTRGSY LCTCRPGLML DPSRSRCVSD
660 670 680 690 700
KAVSMKQGLC YRSMVSGTCT LPLVQRITKQ ICCCSRVGKA WGSKCEHCPL
710 720 730 740 750
PGTEAFREIC PAGHGYAYSS SDIRLSMRKA EEEELASPVR EQRQQSSGPP
760 770 780 790 800
PGAAERQPLR AATATWIEAE TLPDKGDSRA IQITTSAPHL PARVPGDATG
810 820 830 840 850
RPTPSLPGQG IPEGPAEEQV IPSSDVLVTH GPPGFDPCFA GASNICGPGT
860 870 880 890 900
CVKLPNGYRC VCSPGYQLHP SQDYCTDDNE CLRNPCEGRG RCVNSVGSYS
910 920 930 940 950
CLCYPGYTLA TLGDTQECQD VDECEQPGVC SGGRCSNTEG SYHCECDQGY
960 970 980 990 1000
VMVRRGHCQD INECRHPGTC PDGRCVNSPG SYTCLACEEG YIGQSGNCVD
1010 1020 1030 1040 1050
MNECLTPGIC AHGRCINMEG SFRCSCEPGY ELTPDKKGCR DVDECASRAS
1060 1070 1080 1090 1100
CPTGLCLNTE GSFTCSACQS GYWVNEDGTA CEDLDECAFP GVCPTGVCTN
1110 1120 1130 1140 1150
TVGSFSCKDC DRGFRPSPLG NSCEDVDECE GPQNSCLGGE CKNTDGSYQC
1160 1170 1180 1190 1200
LCPQGFQLAN GTVCEDVDEC VGEEHCAPHG ECLNSPGSFF CLCAPGFASA
1210 1220 1230 1240 1250
EGGTRCQDVD ECATTEPCLG GHCVNTEGSF NCLCETGFQP APDSGECVDI
1260 1270 1280 1290 1300
DECANDTVCG NHGFCDNTDG SFRCLCDQGF ETSPSGWECV DVNECELMLA
1310 1320 1330 1340 1350
VCGDALCENV EGSFLCLCAS DLEEYDAEEG HCRPRVAGAQ RIPEVPTEEQ
1360 1370 1380 1390 1400
AAGLTGMECY AEHNGGPPCS QILGQNSTQA ECCSTQGARW GETCDPCPSE
1410 1420 1430 1440 1450
DSVEFSELCP SGQGYIPVEG AWTFGQAMYT DADECILFGP ALCQNGRCLN
1460 1470 1480 1490 1500
TVPGYICLCN PGYHYDAVSR KCQDHNECQD LACENGECVN TEGSFHCFCS
1510 1520 1530 1540 1550
PPLILDLSGQ RCVNSTSSSE DFPDHDIHMD ICWKKVTNDV CSQPLRGHHT
1560 1570 1580 1590 1600
TYTECCCQDG EAWSQQCALC PPRSSEVYAQ LCNVARIEAE REAGIHFRPG
1610 1620 1630 1640 1650
YEYGPGPDDL PETLYGPDGA PFYNYLGPED TVPEPPFSNT ASHLGDNTPI
1660 1670 1680 1690 1700
LEPPLQPSEL QPPAIQNPLA SFEGLQAEEC GILNGCENGR CVRVREGYTC
1710 1720 1730 1740 1750
DCFEGFQLDT ALMACVDVNE CEDLNGAARL CAHGHCENTE GSYRCHCSPG
1760
YVAEPGPPHC AAKE
Length:1,764
Mass (Da):189,867
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i245D57F9CE3386D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2KAU7A0A0G2KAU7_RAT
Latent-transforming growth factor b...
Ltbp2
1,767Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K1G5A0A0G2K1G5_RAT
Latent transforming growth factor b...
Ltbp2 rCG_20726
1,831Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1M7L7F1M7L7_RAT
Latent transforming growth factor b...
Ltbp2 rCG_20726
1,787Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y12760 mRNA Translation: CAA73300.1

NCBI Reference Sequences

More...
RefSeqi
NP_067597.2, NM_021586.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59106

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:59106

UCSC genome browser

More...
UCSCi
RGD:68380, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12760 mRNA Translation: CAA73300.1
RefSeqiNP_067597.2, NM_021586.2

3D structure databases

SMRiO35806
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038437

PTM databases

GlyGeniO35806, 8 sites
iPTMnetiO35806
PhosphoSitePlusiO35806

Proteomic databases

PaxDbiO35806

Genome annotation databases

GeneIDi59106
KEGGirno:59106
UCSCiRGD:68380, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4053
RGDi68380, Ltbp2

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
InParanoidiO35806
PhylomeDBiO35806

Enzyme and pathway databases

ReactomeiR-RNO-2129379, Molecules associated with elastic fibres

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O35806

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF07645, EGF_CA, 14 hits
PF12661, hEGF, 1 hit
PF00683, TB, 4 hits
SMARTiView protein in SMART
SM00181, EGF, 19 hits
SM00179, EGF_CA, 17 hits
SUPFAMiSSF57184, SSF57184, 4 hits
SSF57581, SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00010, ASX_HYDROXYL, 12 hits
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 15 hits
PS51364, TB, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTBP2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35806
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again