Class E basic helix-loop-helix protein 40

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
  • "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Stra13 homodimers repress transcription through class B E-box elements."
    St-Pierre B., Flock G., Zacksenhaus E., Egan S.E.
    J. Biol. Chem. 277:46544-46551(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
  • "Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system."
    Hamaguchi H., Fujimoto K., Kawamoto T., Noshiro M., Maemura K., Takeda N., Nagai R., Furukawa M., Honma S., Honma K., Kurihara H., Kato Y.
    Biochem. J. 382:43-50(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
  • "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter."
    Li Y., Xie M., Song X., Gragen S., Sachdeva K., Wan Y., Yan B.
    J. Biol. Chem. 278:16899-16907(2003) [PubMed] [Europe PMC] [Abstract]
  • "Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system."
    Hamaguchi H., Fujimoto K., Kawamoto T., Noshiro M., Maemura K., Takeda N., Nagai R., Furukawa M., Honma S., Honma K., Kurihara H., Kato Y.
    Biochem. J. 382:43-50(2004) [PubMed] [Europe PMC] [Abstract]
  • "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]
  • "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: UniProtKB
• MRF binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from sequence orthologyⁱ
  • "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
  • "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]
  • "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II activating transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system."
    Hamaguchi H., Fujimoto K., Kawamoto T., Noshiro M., Maemura K., Takeda N., Nagai R., Furukawa M., Honma S., Honma K., Kurihara H., Kato Y.
    Biochem. J. 382:43-50(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor activity Source: UniProtKB

GO - Biological processⁱ

• anterior/posterior pattern specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: UniProtKB
• circadian rhythm Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
• entrainment of circadian clock by photoperiod Source: RGDInferred from sequence orthologyⁱ
  • "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells."
    Yamada K., Kawata H., Mizutani T., Arima T., Yazawa T., Matsuura K., Shou Z., Sekiguchi T., Yoshino M., Kajitani T., Miyamoto K.
    Biol. Reprod. 70:76-82(2004) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation."
    Rossner M.J., Doerr J., Gass P., Schwab M.H., Nave K.-A.
    Mol. Cell. Neurosci. 10:460-475(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• regulation of circadian rhythm Source: UniProtKB
• regulation of neurogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of neuronal synaptic plasticity Source: RGDInferred from expression patternⁱ
  • Ref.1

    "SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation."
    Rossner M.J., Doerr J., Gass P., Schwab M.H., Nave K.-A.
    Mol. Cell. Neurosci. 10:460-475(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• response to light stimulus Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
  • "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]
• MRF binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from sequence orthologyⁱ
  • "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION, TISSUE SPECIFICITY.
  • "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]
  • "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II activating transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements."
    Fujimoto K., Hamaguchi H., Hashiba T., Nakamura T., Kawamoto T., Sato F., Noshiro M., Bhawal U.K., Suardita K., Kato Y.
    Int. J. Mol. Med. 19:925-932(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MERIPSAQPP PTCLPKTPGL EHGDLSGMDF AHMYQVYKSR RGIKRSEDSK 
        60         70         80         90        100
ETYKLPHRLI EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT 
       110        120        130        140        150
LKHVKALTNL IDQQQQKIMA LQSGLQAGDL SGKNIEAGQE MFCSGFQTCA 
       160        170        180        190        200
REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS ELLQGSASRK PLDSAPKPVD 
       210        220        230        240        250
FKEKPSFLAK GSEGPGKNCV PVIQRTFAPS GGEQSGSDTD TDSGYGGELE 
       260        270        280        290        300
KGDLRSEQPY FKSDHGRRFT VGERVSTIKQ ESEEPPTKKS RMQLSDEEGH 
       310        320        330        340        350
FVGSDLMGSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPL 
       360        370        380        390        400
LYPGLNTSAA ALSSFMNPDK IPTPLLLPQR LPSPLAHSSL DSSALLQALK 
       410 
QIPPLNLETK D                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ