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UniProtKB - O35739 (KLF9_MOUSE)
Protein
Krueppel-like factor 9
Gene
Klf9
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 143 – 167 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 173 – 197 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 203 – 225 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- cellular response to cortisol stimulus Source: UniProtKB
- cellular response to thyroid hormone stimulus Source: MGI
- embryo implantation Source: MGI
- negative regulation of keratinocyte proliferation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- progesterone receptor signaling pathway Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 9Alternative name(s): Basic transcription element-binding protein 1 Short name: BTE-binding protein 1 GC-box-binding protein 1 Transcription factor BTEB1 |
Gene namesi | Name:Klf9 Synonyms:Bteb, Bteb-1, Bteb1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333856, Klf9 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047155 | 1 – 244 | Krueppel-like factor 9Add BLAST | 244 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 122 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | O35739 |
PeptideAtlasi | O35739 |
PRIDEi | O35739 |
ProteomicsDBi | 264769 |
PTM databases
iPTMneti | O35739 |
PhosphoSitePlusi | O35739 |
Interactioni
Subunit structurei
Interacts with ZZEF1.
By similarityProtein-protein interaction databases
IntActi | O35739, 2 interactors |
STRINGi | 10090.ENSMUSP00000045639 |
Miscellaneous databases
RNActi | O35739, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 51 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 79 – 143 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 51 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 98 – 126 | Polar residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 143 – 167 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 173 – 197 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 203 – 225 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | O35739 |
PhylomeDBi | O35739 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O35739-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAAAYMDFV AAQCLVSISN RAAVPEHGGA PEAERLRLPE REVTKEHGDP
60 70 80 90 100
GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDIGSDSDVT
110 120 130 140 150
TESGSSPSHS PEERQDSGSA PSPLSLLHSG VASKGKHASE KRHKCPYSGC
160 170 180 190 200
GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE
210 220 230 240
KQFRCPLCEK RFMRSDHLTK HARRHTVFHP SMIKRSKKAL ACPL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8CEC4 | Q8CEC4_MOUSE | Bteb1 protein | Klf9 Bteb1 | 244 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14296 mRNA Translation: CAA74671.1 |
CCDSi | CCDS29706.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14296 mRNA Translation: CAA74671.1 |
CCDSi | CCDS29706.1 |
3D structure databases
SMRi | O35739 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O35739, 2 interactors |
STRINGi | 10090.ENSMUSP00000045639 |
PTM databases
iPTMneti | O35739 |
PhosphoSitePlusi | O35739 |
Proteomic databases
PaxDbi | O35739 |
PeptideAtlasi | O35739 |
PRIDEi | O35739 |
ProteomicsDBi | 264769 |
Organism-specific databases
MGIi | MGI:1333856, Klf9 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | O35739 |
PhylomeDBi | O35739 |
Miscellaneous databases
ChiTaRSi | Klf9, mouse |
PROi | PR:O35739 |
RNActi | O35739, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF9_MOUSE | |
Accessioni | O35739Primary (citable) accession number: O35739 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families