Klf12

Functionⁱ

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	317 – 341	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	347 – 371	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	377 – 399	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 9858544
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 16615998
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9858544
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9858544

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 9858544
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 16615998
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 9858544
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 12 Alternative name(s): Transcriptional repressor AP-2rep
Gene namesⁱ	Name:Klf12 Synonyms:Ap2rep
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1333796 Klf12

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047183	1 – 402	Krueppel-like factor 12Add BLAST		402

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	202	PhosphoserineCombined sources		1
Modified residueⁱ	313	N6-methylated lysine; by EHMT2By similarity		1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O35738
PaxDbⁱ	O35738
PeptideAtlas More...PeptideAtlasⁱ	O35738
PRIDEⁱ	O35738

PTM databases

iPTMnetⁱ	O35738
PhosphoSitePlusⁱ	O35738

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000072294 Expressed in 62 organ(s), highest expression level in head
CleanExⁱ	MM_KLF12
Genevisibleⁱ	O35738 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000094844

STRINGⁱ

10090.ENSMUSP00000094844

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35738
SMRⁱ	O35738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	317 – 341	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	347 – 371	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	377 – 399	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118998
HOGENOMⁱ	HOG000232138
HOVERGENⁱ	HBG003941
InParanoidⁱ	O35738
KEGG Orthology (KO) More...KOⁱ	K09205
OMAⁱ	MYTTAVR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
TreeFamⁱ	TF350556

Family and domain databases

InterProⁱ	View protein in InterPro IPR030447 KLF12 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44639 PTHR44639, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O35738-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNIHMKRKTI KNLSALENRM LMLDGMPAVR VKTELVESEQ GSPNVHNYPD 
        60         70         80         90        100
MEAVPLLLNN VKGEPPEDSL PVDHFQTQTE PVDLSINKAR TSPTAASSSP 
       110        120        130        140        150
VSMTASASSP SSTSTSSSSS SRPASSPTVI TSVSSASSSS TVLSPGPLVA 
       160        170        180        190        200
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV 
       210        220        230        240        250
RSPGNVNNTI VVPLLEDGRS HGKAQMEPRG LSPRQSKSDS DDDDLPNVTL 
       260        270        280        290        300
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFAC SISPFSIEST 
       310        320        330        340        350
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT 
       360        370        380        390        400
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM 

LV

Length:402

Mass (Da):44,105

Last modified:July 27, 2011 - v2

Checksum:ⁱB80D73C2123F1FF5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2I3BQ01	A0A2I3BQ01_MOUSE		Krueppel-like factor 12 Krueppel-like factor 12	Klf12	153	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	105	A → G in CAA74670 (PubMed:9858544).Curated	1
Sequence conflictⁱ	135	S → R in CAA74670 (PubMed:9858544).Curated	1
Sequence conflictⁱ	359	A → G in CAA74670 (PubMed:9858544).Curated	1
Sequence conflictⁱ	385	S → R in CAA74670 (PubMed:9858544).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14295 mRNA Translation: CAA74670.1 BC067408 mRNA Translation: AAH67408.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36998.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034766.2, NM_010636.3 XP_006518686.1, XM_006518623.3 XP_006518687.1, XM_006518624.3 XP_011243270.1, XM_011244968.2 XP_011243271.1, XM_011244969.2
UniGeneⁱ	Mm.396499 Mm.458816

Genome annotation databases

Ensemblⁱ	ENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294 ENSMUST00000228216; ENSMUSP00000153901; ENSMUSG00000072294
GeneIDⁱ	16597
KEGGⁱ	mmu:16597
UCSC genome browser More...UCSCⁱ	uc007uvh.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35738	Krueppel-like factor 12 (Fragment)		MOUSE		153	UniRef100_O35738
UPI000154ADEA		MOUSE		383
UPI0003D6F636		MOUSE		352

Protein	Similar proteins		Species	Score	Length	Source
O35738	Krueppel-like factor 12		HUMAN		402	UniRef90_Q9Y4X4
Krueppel-like factor 12		MACMU		402
KLF12 isoform 2		PANTR		402
Kruppel like factor 12		MACFA		402
Uncharacterized protein		COLAP		402
+170

Protein	Similar proteins		Species	Score	Length	Source
O35738	Krueppel-like factor 12		HUMAN		402	UniRef50_Q9Y4X4
Krueppel-like factor 12		MACMU		402
KLF12 isoform 2		PANTR		402
Kruppel like factor 12		MACFA		402
Uncharacterized protein		COLAP		402
+343

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14295 mRNA Translation: CAA74670.1 BC067408 mRNA Translation: AAH67408.1
CCDSⁱ	CCDS36998.1
RefSeqⁱ	NP_034766.2, NM_010636.3 XP_006518686.1, XM_006518623.3 XP_006518687.1, XM_006518624.3 XP_011243270.1, XM_011244968.2 XP_011243271.1, XM_011244969.2
UniGeneⁱ	Mm.396499 Mm.458816

3D structure databases

ProteinModelPortalⁱ	O35738
SMRⁱ	O35738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000094844

STRINGⁱ

10090.ENSMUSP00000094844

PTM databases

iPTMnetⁱ	O35738
PhosphoSitePlusⁱ	O35738

Proteomic databases

MaxQBⁱ	O35738
PaxDbⁱ	O35738
PeptideAtlasⁱ	O35738
PRIDEⁱ	O35738

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294 ENSMUST00000228216; ENSMUSP00000153901; ENSMUSG00000072294
GeneIDⁱ	16597
KEGGⁱ	mmu:16597
UCSCⁱ	uc007uvh.2 mouse

Organism-specific databases

CTDⁱ	11278
MGIⁱ	MGI:1333796 Klf12

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118998
HOGENOMⁱ	HOG000232138
HOVERGENⁱ	HBG003941
InParanoidⁱ	O35738
KOⁱ	K09205
OMAⁱ	MYTTAVR
OrthoDBⁱ	EOG091G1BN0
TreeFamⁱ	TF350556

Miscellaneous databases

ChiTaRSⁱ	Klf12 mouse
Protein Ontology More...PROⁱ	PR:O35738
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000072294 Expressed in 62 organ(s), highest expression level in head
CleanExⁱ	MM_KLF12
Genevisibleⁱ	O35738 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR030447 KLF12 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44639 PTHR44639, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF12_MOUSE
Accessionⁱ	O35738Primary (citable) accession number: O35738 Secondary accession number(s): Q6NWV9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O35738 (KLF12_MOUSE)

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Krueppel-like factor 12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ