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Protein

Krueppel-like factor 12

Gene

Klf12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri317 – 341C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene namesi
Name:Klf12
Synonyms:Ap2rep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1333796 Klf12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471831 – 402Krueppel-like factor 12Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1
Modified residuei313N6-methylated lysine; by EHMT2By similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO35738
PaxDbiO35738
PeptideAtlasiO35738
PRIDEiO35738

PTM databases

iPTMnetiO35738
PhosphoSitePlusiO35738

Expressioni

Gene expression databases

BgeeiENSMUSG00000072294 Expressed in 62 organ(s), highest expression level in head
CleanExiMM_KLF12
GenevisibleiO35738 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094844

Structurei

3D structure databases

ProteinModelPortaliO35738
SMRiO35738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri317 – 341C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000232138
HOVERGENiHBG003941
InParanoidiO35738
KOiK09205
OMAiMYTTAVR
OrthoDBiEOG091G1BN0
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR030447 KLF12
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44639 PTHR44639, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIHMKRKTI KNLSALENRM LMLDGMPAVR VKTELVESEQ GSPNVHNYPD
60 70 80 90 100
MEAVPLLLNN VKGEPPEDSL PVDHFQTQTE PVDLSINKAR TSPTAASSSP
110 120 130 140 150
VSMTASASSP SSTSTSSSSS SRPASSPTVI TSVSSASSSS TVLSPGPLVA
160 170 180 190 200
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV
210 220 230 240 250
RSPGNVNNTI VVPLLEDGRS HGKAQMEPRG LSPRQSKSDS DDDDLPNVTL
260 270 280 290 300
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFAC SISPFSIEST
310 320 330 340 350
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT
360 370 380 390 400
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM

LV
Length:402
Mass (Da):44,105
Last modified:July 27, 2011 - v2
Checksum:iB80D73C2123F1FF5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQ01A0A2I3BQ01_MOUSE
Krueppel-like factor 12
Klf12
153Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105A → G in CAA74670 (PubMed:9858544).Curated1
Sequence conflicti135S → R in CAA74670 (PubMed:9858544).Curated1
Sequence conflicti359A → G in CAA74670 (PubMed:9858544).Curated1
Sequence conflicti385S → R in CAA74670 (PubMed:9858544).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14295 mRNA Translation: CAA74670.1
BC067408 mRNA Translation: AAH67408.1
CCDSiCCDS36998.1
RefSeqiNP_034766.2, NM_010636.3
XP_006518686.1, XM_006518623.3
XP_006518687.1, XM_006518624.3
XP_011243270.1, XM_011244968.2
XP_011243271.1, XM_011244969.2
UniGeneiMm.396499
Mm.458816

Genome annotation databases

EnsembliENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294
ENSMUST00000228216; ENSMUSP00000153901; ENSMUSG00000072294
GeneIDi16597
KEGGimmu:16597
UCSCiuc007uvh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14295 mRNA Translation: CAA74670.1
BC067408 mRNA Translation: AAH67408.1
CCDSiCCDS36998.1
RefSeqiNP_034766.2, NM_010636.3
XP_006518686.1, XM_006518623.3
XP_006518687.1, XM_006518624.3
XP_011243270.1, XM_011244968.2
XP_011243271.1, XM_011244969.2
UniGeneiMm.396499
Mm.458816

3D structure databases

ProteinModelPortaliO35738
SMRiO35738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094844

PTM databases

iPTMnetiO35738
PhosphoSitePlusiO35738

Proteomic databases

MaxQBiO35738
PaxDbiO35738
PeptideAtlasiO35738
PRIDEiO35738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294
ENSMUST00000228216; ENSMUSP00000153901; ENSMUSG00000072294
GeneIDi16597
KEGGimmu:16597
UCSCiuc007uvh.2 mouse

Organism-specific databases

CTDi11278
MGIiMGI:1333796 Klf12

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000232138
HOVERGENiHBG003941
InParanoidiO35738
KOiK09205
OMAiMYTTAVR
OrthoDBiEOG091G1BN0
TreeFamiTF350556

Miscellaneous databases

ChiTaRSiKlf12 mouse
PROiPR:O35738
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072294 Expressed in 62 organ(s), highest expression level in head
CleanExiMM_KLF12
GenevisibleiO35738 MM

Family and domain databases

InterProiView protein in InterPro
IPR030447 KLF12
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44639 PTHR44639, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF12_MOUSE
AccessioniPrimary (citable) accession number: O35738
Secondary accession number(s): Q6NWV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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