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Protein

Heterogeneous nuclear ribonucleoprotein H

Gene

Hnrnph1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-6803529 FGFR2 alternative splicing
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H
Short name:
hnRNP H
Cleaved into the following chain:
Gene namesi
Name:Hnrnph1
Synonyms:Hnrph, Hnrph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1891925 Hnrnph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818581 – 449Heterogeneous nuclear ribonucleoprotein HAdd BLAST449
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003671202 – 449Heterogeneous nuclear ribonucleoprotein H, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei54PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei233Dimethylated arginine; alternateBy similarity1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1
Modified residuei246PhosphotyrosineBy similarity1
Modified residuei310PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO35737
PaxDbiO35737
PeptideAtlasiO35737
PRIDEiO35737

2D gel databases

REPRODUCTION-2DPAGEiIPI00133916
O35737

PTM databases

iPTMnetiO35737
PhosphoSitePlusiO35737
SwissPalmiO35737

Expressioni

Gene expression databases

BgeeiENSMUSG00000007850 Expressed in 298 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiO35737 baseline and differential
GenevisibleiO35737 MM

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent (By similarity).By similarity

Protein-protein interaction databases

BioGridi208484, 12 interactors
CORUMiO35737
IntActiO35737, 15 interactors
MINTiO35737
STRINGi10090.ENSMUSP00000070503

Structurei

3D structure databases

ProteinModelPortaliO35737
SMRiO35737
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Domaini

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiO35737
KOiK12898

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35737-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLGAEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA
Length:449
Mass (Da):49,199
Last modified:January 23, 2007 - v3
Checksum:iBF6138CA982D5484
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C2Q7Q8C2Q7_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnph1 Hnrph1
472Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14196 mRNA Translation: CAA74583.1
BC056224 mRNA Translation: AAH56224.1
CCDSiCCDS24634.1
RefSeqiNP_067485.1, NM_021510.2
XP_017170179.1, XM_017314690.1
XP_017170180.1, XM_017314691.1
UniGeneiMm.21740

Genome annotation databases

EnsembliENSMUST00000069304; ENSMUSP00000070503; ENSMUSG00000007850
ENSMUST00000109142; ENSMUSP00000104770; ENSMUSG00000007850
GeneIDi59013
KEGGimmu:59013
UCSCiuc007isj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14196 mRNA Translation: CAA74583.1
BC056224 mRNA Translation: AAH56224.1
CCDSiCCDS24634.1
RefSeqiNP_067485.1, NM_021510.2
XP_017170179.1, XM_017314690.1
XP_017170180.1, XM_017314691.1
UniGeneiMm.21740

3D structure databases

ProteinModelPortaliO35737
SMRiO35737
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208484, 12 interactors
CORUMiO35737
IntActiO35737, 15 interactors
MINTiO35737
STRINGi10090.ENSMUSP00000070503

PTM databases

iPTMnetiO35737
PhosphoSitePlusiO35737
SwissPalmiO35737

2D gel databases

REPRODUCTION-2DPAGEiIPI00133916
O35737

Proteomic databases

EPDiO35737
PaxDbiO35737
PeptideAtlasiO35737
PRIDEiO35737

Protocols and materials databases

DNASUi59013
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069304; ENSMUSP00000070503; ENSMUSG00000007850
ENSMUST00000109142; ENSMUSP00000104770; ENSMUSG00000007850
GeneIDi59013
KEGGimmu:59013
UCSCiuc007isj.1 mouse

Organism-specific databases

CTDi3187
MGIiMGI:1891925 Hnrnph1

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiO35737
KOiK12898

Enzyme and pathway databases

ReactomeiR-MMU-6803529 FGFR2 alternative splicing
R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiHnrnph1 mouse
PROiPR:O35737
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007850 Expressed in 298 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiO35737 baseline and differential
GenevisibleiO35737 MM

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH1_MOUSE
AccessioniPrimary (citable) accession number: O35737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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