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Protein

Suppressor of cytokine signaling 2

Gene

Socs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Miscellaneous

Mice deficient in SOCS2 exhibit considerable weight increase (30-40% more than normal) after 3 weeks of age. This is attributable to increase in visceral organ weight, carcass weight, long bone length and body length. In addition there is a thickening of the dermis due to excess collagen accumulation.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
  • growth hormone receptor binding Source: MGI
  • insulin-like growth factor receptor binding Source: UniProtKB
  • JAK pathway signal transduction adaptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 2
Short name:
SOCS-2
Alternative name(s):
Cytokine-inducible SH2 protein 2
Short name:
CIS-2
Gene namesi
Name:Socs2
Synonyms:Cis2, Cish2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1201787 Socs2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812391 – 198Suppressor of cytokine signaling 2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35717
PaxDbiO35717
PRIDEiO35717

PTM databases

PhosphoSitePlusiO35717

Expressioni

Tissue specificityi

Expressed primarily in the testis, some expression in liver and lung.

Developmental stagei

In the developing brain, expressed at relatively high levels from E10 stages to young adulthood (P25) with peak levels from E14 to P8. Levels of SOCS2 increase dramatically between E10 and E12. At E12, high expression found in the olfactory epithelium with moderate expression in the neuroepithelium of the neocortex, presumptive striatum, hippocampus and septum. Low expression in the retina. At E14, in the cortical wall, levels increase in the cortical plate and decrease in the intermediate zone. High expression also in the hippocampus, fimbria, thalamic neuroepithelium and innermost layer of the retina. At P8, high expression in the neurons of the hippocampus. Lower levels found in the dentate gyrus. Levels of expression decrease between P8 and P15 and remain constant until P25. In adulthood, levels decrease. In the peripheral nervous system, expression found at low levels at E14 in a subpopulation of neurons in the dorsal root ganglion.1 Publication

Gene expression databases

BgeeiENSMUSG00000020027 Expressed in 281 organ(s), highest expression level in cumulus cell
CleanExiMM_SOCS2
ExpressionAtlasiO35717 baseline and differential
GenevisibleiO35717 MM

Interactioni

Subunit structurei

Associates with the Elongin BC complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229727, 13 interactors
IntActiO35717, 3 interactors
MINTiO35717
STRINGi10090.ENSMUSP00000020215

Structurei

3D structure databases

ProteinModelPortaliO35717
SMRiO35717
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 156SH2PROSITE-ProRule annotationAdd BLAST109
Domaini151 – 197SOCS boxPROSITE-ProRule annotationAdd BLAST47

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000236320
HOVERGENiHBG002457
InParanoidiO35717
KOiK04695
OMAiHLYLNKP
OrthoDBiEOG091G0J75
PhylomeDBiO35717
TreeFamiTF321368

Family and domain databases

CDDicd10383 SH2_SOCS2, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028410 SOCS2
IPR035862 SOCS2_SH2
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44396 PTHR44396, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O35717-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRCLEPSG NGADRTRSQW GTAGLPEEQS PEAARLAKAL RELSQTGWYW
60 70 80 90 100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ
110 120 130 140 150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL
160 170 180 190
YLTKPLYTSA PTLQHFCRLA INKCTGTIWG LPLPTRLKDY LEEYKFQV
Length:198
Mass (Da):22,434
Last modified:January 1, 1998 - v1
Checksum:iC9051AE9C84BA7F5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RVG2F6RVG2_MOUSE
Suppressor of cytokine-signaling 2
Socs2
201Annotation score:
D3YZ26D3YZ26_MOUSE
Suppressor of cytokine-signaling 2
Socs2
80Annotation score:
D3Z355D3Z355_MOUSE
Suppressor of cytokine-signaling 2
Socs2
70Annotation score:
D3Z441D3Z441_MOUSE
Suppressor of cytokine-signaling 2
Socs2
62Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88327 mRNA Translation: AAB62402.1
CCDSiCCDS24136.1
RefSeqiNP_001162126.1, NM_001168655.1
NP_001162127.1, NM_001168656.1
NP_001162128.1, NM_001168657.1
NP_031732.1, NM_007706.4
XP_011241712.1, XM_011243410.2
UniGeneiMm.474283
Mm.490329

Genome annotation databases

EnsembliENSMUST00000020215; ENSMUSP00000020215; ENSMUSG00000020027
ENSMUST00000119917; ENSMUSP00000113378; ENSMUSG00000020027
ENSMUST00000170690; ENSMUSP00000129331; ENSMUSG00000020027
ENSMUST00000172070; ENSMUSP00000131875; ENSMUSG00000020027
GeneIDi216233
KEGGimmu:216233
UCSCiuc007gwg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88327 mRNA Translation: AAB62402.1
CCDSiCCDS24136.1
RefSeqiNP_001162126.1, NM_001168655.1
NP_001162127.1, NM_001168656.1
NP_001162128.1, NM_001168657.1
NP_031732.1, NM_007706.4
XP_011241712.1, XM_011243410.2
UniGeneiMm.474283
Mm.490329

3D structure databases

ProteinModelPortaliO35717
SMRiO35717
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229727, 13 interactors
IntActiO35717, 3 interactors
MINTiO35717
STRINGi10090.ENSMUSP00000020215

PTM databases

PhosphoSitePlusiO35717

Proteomic databases

EPDiO35717
PaxDbiO35717
PRIDEiO35717

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020215; ENSMUSP00000020215; ENSMUSG00000020027
ENSMUST00000119917; ENSMUSP00000113378; ENSMUSG00000020027
ENSMUST00000170690; ENSMUSP00000129331; ENSMUSG00000020027
ENSMUST00000172070; ENSMUSP00000131875; ENSMUSG00000020027
GeneIDi216233
KEGGimmu:216233
UCSCiuc007gwg.2 mouse

Organism-specific databases

CTDi8835
MGIiMGI:1201787 Socs2

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000236320
HOVERGENiHBG002457
InParanoidiO35717
KOiK04695
OMAiHLYLNKP
OrthoDBiEOG091G0J75
PhylomeDBiO35717
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSiSocs2 mouse
PROiPR:O35717
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020027 Expressed in 281 organ(s), highest expression level in cumulus cell
CleanExiMM_SOCS2
ExpressionAtlasiO35717 baseline and differential
GenevisibleiO35717 MM

Family and domain databases

CDDicd10383 SH2_SOCS2, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028410 SOCS2
IPR035862 SOCS2_SH2
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44396 PTHR44396, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS2_MOUSE
AccessioniPrimary (citable) accession number: O35717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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