UniProtKB - O35717 (SOCS2_MOUSE)
Protein
Suppressor of cytokine signaling 2
Gene
Socs2
Organism
Mus musculus (Mouse)
Status
Functioni
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity
Miscellaneous
Mice deficient in SOCS2 exhibit considerable weight increase (30-40% more than normal) after 3 weeks of age. This is attributable to increase in visceral organ weight, carcass weight, long bone length and body length. In addition there is a thickening of the dermis due to excess collagen accumulation.
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
- growth hormone receptor binding Source: MGI
- insulin-like growth factor receptor binding Source: UniProtKB
- JAK pathway signal transduction adaptor activity Source: InterPro
GO - Biological processi
- cellular response to hormone stimulus Source: MGI
- growth hormone receptor signaling pathway Source: MGI
- intracellular signal transduction Source: MGI
- lactation Source: MGI
- mammary gland alveolus development Source: MGI
- negative regulation of multicellular organism growth Source: MGI
- negative regulation of receptor signaling pathway via JAK-STAT Source: MGI
- phosphatidylinositol phosphorylation Source: GO_Central
- positive regulation of neuron differentiation Source: MGI
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of cell growth Source: InterPro
- regulation of multicellular organism growth Source: MGI
- response to estradiol Source: MGI
Keywordsi
Molecular function | Signal transduction inhibitor |
Biological process | Growth regulation, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of cytokine signaling 2Short name: SOCS-2 Alternative name(s): Cytokine-inducible SH2 protein 2 Short name: CIS-2 |
Gene namesi | Name:Socs2 Synonyms:Cis2, Cish2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1201787, Socs2 |
Subcellular locationi
Other locations
- cytoplasm Source: InterPro
- phosphatidylinositol 3-kinase complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181239 | 1 – 198 | Suppressor of cytokine signaling 2Add BLAST | 198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 30 | PhosphoserineBy similarity | 1 | |
Modified residuei | 52 | Phosphoserine; by PKC1 Publication | 1 | |
Cross-linki | 173 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312). Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS (PubMed:31578312).1 Publication
Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.1 Publication
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O35717 |
PaxDbi | O35717 |
PRIDEi | O35717 |
PTM databases
PhosphoSitePlusi | O35717 |
Expressioni
Tissue specificityi
Expressed primarily in the testis, some expression in liver and lung.
Developmental stagei
In the developing brain, expressed at relatively high levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. Levels of SOCS2 increase dramatically between 10 dpc and 12 dpc. At 12 dpc, high expression found in the olfactory epithelium with moderate expression in the neuroepithelium of the neocortex, presumptive striatum, hippocampus and septum. Low expression in the retina. At 14 dpc, in the cortical wall, levels increase in the cortical plate and decrease in the intermediate zone. High expression also in the hippocampus, fimbria, thalamic neuroepithelium and innermost layer of the retina. At P8, high expression in the neurons of the hippocampus. Lower levels found in the dentate gyrus. Levels of expression decrease between P8 and P15 and remain constant until P25. In adulthood, levels decrease. In the peripheral nervous system, expression found at low levels at 14 dpc in a subpopulation of neurons in the dorsal root ganglion.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020027, Expressed in cumulus cell and 298 other tissues |
Genevisiblei | O35717, MM |
Interactioni
Subunit structurei
Interacts with IGF1R (By similarity). Associates with the Elongin BC complex (By similarity).
Interacts with AREL1 and PRKCA (PubMed:31578312).
Interacts with DCUN1D1 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- growth hormone receptor binding Source: MGI
- insulin-like growth factor receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 229727, 13 interactors |
IntActi | O35717, 3 interactors |
MINTi | O35717 |
STRINGi | 10090.ENSMUSP00000020215 |
Miscellaneous databases
RNActi | O35717, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 156 | SH2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 151 – 197 | SOCS boxPROSITE-ProRule annotationAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 75 | Interaction with AREL1By similarityAdd BLAST | 75 |
Domaini
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000157983 |
HOGENOMi | CLU_079452_4_0_1 |
InParanoidi | O35717 |
OMAi | IEYYVLM |
OrthoDBi | 1135696at2759 |
PhylomeDBi | O35717 |
TreeFami | TF321368 |
Family and domain databases
CDDi | cd10383, SH2_SOCS2, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028410, SOCS2 IPR035862, SOCS2_SH2 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF7, PTHR10155:SF7, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O35717-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLRCLEPSG NGADRTRSQW GTAGLPEEQS PEAARLAKAL RELSQTGWYW
60 70 80 90 100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ
110 120 130 140 150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL
160 170 180 190
YLTKPLYTSA PTLQHFCRLA INKCTGTIWG LPLPTRLKDY LEEYKFQV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6RVG2 | F6RVG2_MOUSE | Suppressor of cytokine signaling 2 | Socs2 | 201 | Annotation score: | ||
D3YZ26 | D3YZ26_MOUSE | Suppressor of cytokine-signaling 2 | Socs2 | 80 | Annotation score: | ||
D3Z355 | D3Z355_MOUSE | Suppressor of cytokine-signaling 2 | Socs2 | 70 | Annotation score: | ||
D3Z441 | D3Z441_MOUSE | Suppressor of cytokine-signaling 2 | Socs2 | 62 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88327 mRNA Translation: AAB62402.1 |
CCDSi | CCDS24136.1 |
RefSeqi | NP_001162126.1, NM_001168655.1 NP_001162127.1, NM_001168656.1 NP_001162128.1, NM_001168657.1 NP_031732.1, NM_007706.4 XP_011241712.1, XM_011243410.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88327 mRNA Translation: AAB62402.1 |
CCDSi | CCDS24136.1 |
RefSeqi | NP_001162126.1, NM_001168655.1 NP_001162127.1, NM_001168656.1 NP_001162128.1, NM_001168657.1 NP_031732.1, NM_007706.4 XP_011241712.1, XM_011243410.2 |
3D structure databases
SMRi | O35717 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229727, 13 interactors |
IntActi | O35717, 3 interactors |
MINTi | O35717 |
STRINGi | 10090.ENSMUSP00000020215 |
PTM databases
PhosphoSitePlusi | O35717 |
Proteomic databases
EPDi | O35717 |
PaxDbi | O35717 |
PRIDEi | O35717 |
Protocols and materials databases
Antibodypediai | 4158, 277 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 8835 |
MGIi | MGI:1201787, Socs2 |
Phylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000157983 |
HOGENOMi | CLU_079452_4_0_1 |
InParanoidi | O35717 |
OMAi | IEYYVLM |
OrthoDBi | 1135696at2759 |
PhylomeDBi | O35717 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 216233, 0 hits in 17 CRISPR screens |
ChiTaRSi | Socs2, mouse |
PROi | PR:O35717 |
RNActi | O35717, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020027, Expressed in cumulus cell and 298 other tissues |
Genevisiblei | O35717, MM |
Family and domain databases
CDDi | cd10383, SH2_SOCS2, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028410, SOCS2 IPR035862, SOCS2_SH2 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF7, PTHR10155:SF7, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOCS2_MOUSE | |
Accessioni | O35717Primary (citable) accession number: O35717 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways